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Lecture 17 Nucleus pp91-95.

Published by Isaiah Lugg Modified over 9 years ago

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Presentation on theme: "Lecture 17 Nucleus pp91-95."— Presentation transcript:

Cells: The Living Units

NUCLEIC ACIDS : DNA and RNA Nucleic Acids Very Large, Complex, DNA & RNA Store Important Info in the Cell. (Genetic Information) ATP is an energy carrier.

DNA STRUCTURE. NUCLEIC ACIDS Include DNA: Deoxyribonucleic acid RNA: Ribonucleic acid.

Copyright Pearson Prentice Hall

Cell Components III The nucleus and nucleic acids

ORGANELLES OF THE CYTOPLASM. Cytoplasm Located between plasma membrane and nucleus Cytosol Water with solutes (protein, salts, sugars, etc.) Cytoplasmic.

Nucleic Acids - RNA and DNA is a complex, high-molecular- weight biochemical macromolecule composed of chains that convey genetic information. The most.

Chapter 17 Nucleotides, Nucleic Acids, and Heredity.

NUCLEIC ACIDS BY DR. MARYJANE. Are of two types: DNA RNA.

Introduction Nucleic acids are macromolecules made up of smaller nucleotide subunits. They carry genetic information, form specific structures in a cell.

Nucleic acids Nucleic Acids Contain carbon, hydrogen, oxygen and phosphorus. Building blocks for genetic material DNA and RNA most common. Made of monomers.

Nucleic Acids.

Cell Structure and Function Chapter 3 Basic Characteristics of Cells Smallest living subdivision of the human body Diverse in structure and function.

Biochemistry Part IV Nucleic Acids. Largest organic molecule made by organisms Largest organic molecule made by organisms Include 2 main types: Include.

Transcription and Translation… Its what make you, YOU!

Chapter 5 (Please do read every single page)

Nucleic Acids DNA vs. RNA

Chap. 4—Genetics and Cellular Function

Human Anatomy & Physiology FIFTH EDITION Elaine N. Marieb PowerPoint ® Lecture Slide Presentation by Vince Austin Copyright © 2003 Pearson Education, Inc.

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Powerpoint Templates and Google slides for Nucleus

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Presenting our Caudate Nucleus Function In Powerpoint And Google Slides Cpb PowerPoint template design. This PowerPoint slide showcases five stages. It is useful to share insightful information on Caudate Nucleus Function This PPT slide can be easily accessed in standard screen and widescreen aspect ratios. It is also available in various formats like PDF, PNG, and JPG. Not only this, the PowerPoint slideshow is completely editable and you can effortlessly modify the font size, font type, and shapes according to your wish. Our PPT layout is compatible with Google Slides as well, so download and edit it as per your knowledge.

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Presenting inbound marketing nucleus powerpoint slide introduction. This is a inbound marketing nucleus powerpoint slide introduction. This is a six stage process. The stages in this process are search, blogs, content, email, pay per click, social media, inbound marketing nucleus diagram.

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• Ease of Collaboration
• Offline Access
• Integration With Other Google Tools
• More Storage Space
• Compatibility With PowerPoint
• AI Features
• Provide Detailed Version History
• Customization Features and Template Options

PowerPoint and Google Slides are two popular options for presentations, but which one is best? As someone who has used both programs for a long time, I've found that Google Slides offers many advantages that make it my go-to choice.

Let's be clear: I'm comparing the web-based PowerPoint and Google Slides versions. It's unfair to compare Google Slides to the desktop version of PowerPoint, isn't it? Here are some reasons why Google Slides is my favorite presentation tool.

1. Ease of Collaboration

Ease of collaboration was the central reason I switched to Google Slides for my presentation needs. As a content creator, I always aim for a seamless collaboration experience while dealing with my clients and team members. Google Slides offered exactly that, and I was in love with it.

So, is Google Slides better than PowerPoint for collaboration? It certainly has advantages that make it an ideal choice for a lot of users.

With Google Slides, you can efficiently work with others and share your work , no matter what kind of computer or phone you use. If you have a Google account and the link to the presentation, you can join in and make changes simultaneously with other members.

In contrast, to collaborate in PowerPoint, you have to consider various external factors, such as the user's working device and storage locations. For example, you might not be able to easily collaborate with someone who has an older version of PowerPoint, or with someone using a PowerPoint mobile due to feature limitations. Some things that are restricted in the free web and mobile version compared to PowerPoint on desktop include limited commenting tags, editing options, and more.

Additionally, Google Slides also has built-in chat and commenting features. This feature allows all your team members to stay on the same page and communicate with each other to streamline editing. In PowerPoint, you're limited to comments only.

2. Offline Access

Another important reason for my switch to Google Slides is the offline access feature. With this feature, you can create, edit, and present presentations to others even without an internet connection. Any changes you apply offline are synced automatically once you're back online, so you can keep working even without an internet connection.

You can activate offline access by checking the offline mode option in your Google Drive settings.

Also, with Google Slides, you don't need software installed on your computer to access your presentations offline. However, Microsoft PowerPoint requires an internet connection to save changes to OneDrive storage. No internet, no autosave!

3. Integration With Other Google Tools

Switching to Google Slides is easy if you already use Google apps like Docs, Sheet, Meet, and Gmail. They all work well together. You can import charts and tables from Google Sheets into your presentations with just a few clicks. Any modifications to the original data in Google Sheets will automatically be reflected in your Google Slides presentation.

For example, on Google Slides, open the "Insert" tab and navigate to the "Chart" option. From there, click on the "From Sheets" option and import a chart from Google Sheets.

Furthermore, you can add Google Keep notes to your Slides and share your content in Google Meet with Smart Canvas without switching between tabs.

On the other hand, Microsoft PowerPoint integrates with other Microsoft tools, but it's not as seamless as Google Slides and has limited integration capabilities. For example, unlike Google Sheets, which updates data automatically in Slides, PowerPoint requires you to manual refresh to update Excel charts. This means you need to copy and paste the updated chart from Excel to PowerPoint.

4. More Storage Space

Google Slides offers more storage space through Google Drive. With a Google account, you get 15GB of storage shared across Google Photos, Drive, and Gmail. This is significantly more than what Microsoft offers with its free PowerPoint Web version, which only provides 5GB of OneDrive storage. If you create large presentations with many images or videos, Google's extra storage space can be a significant advantage.

Additionally, Google offers affordable plans to upgrade your storage if needed. For example, you can get 100GB of storage for a $20 annual fee, which is perfect for those who create and store a lot of presentations. However, it's important to note that pricing for additional storage might be different depending on your region.

For detailed information, it's best to check your plans manually by clicking the "Get More Storage" option in Drive.

5. Compatibility With PowerPoint

I know what you're thinking—what if I need to work with someone who only uses Microsoft PowerPoint? Fear not; Google Slides has got you covered. You can import and export PowerPoint presentations into Google Slides, making switching between the two platforms easy.

This feature has been a lifesaver for me when I work with my clients or colleagues who use PowerPoint. I can easily collaborate with them and edit their files without any hassle. After making changes, I can save the Google Slides file again as a PowerPoint file.

You can add your PowerPoint file to Google Slides by either uploading it on Drive or directly opening it from the File > Open option.

6. AI Features

You can also use Google AI tools like Gemini to improve your presentations. For example, the Gemini AI feature in Google Slides allows users to generate images and slides based on their prompts. You can access Gemini from the Slides side panel and input your prompts, such as "Create a slide about," and it will generate slides accordingly.

This feature lets you quickly add relevant and visually appealing presentation content without leaving the Google Slides platform. Using Gemini AI, you can also generate background images in various styles, such as Vector art, Photography, Watercolor, and others.

In contrast, Microsoft AI feature tools like Copilot are not available on the PowerPoint web version. To use Copilot and other AI features in PowerPoint requires a paid subscription to either Microsoft 365 or Copilot Pro.

7. Provide Detailed Version History

Both Google Slides and Microsoft PowerPoint allow you to view and restore previously edited versions of your presentation. However, Google Slides stands out with its detailed version history feature. This feature groups certain versions of your presentation together if you make multiple changes over a short period. This makes it easy to find and select the version you need. These group versions are displayed under the Version History panel.

Another notable feature of Google Slides is the ability to name the modified versions. This is quite useful when working on large documents with multiple collaborators, as it can take time to find the version you want, among many others. To rename a version, open the "Version History" panel, click the three-dot icon, and then select "Name This Version" from the dropdown menu.

Once you've named important versions of your presentation, you can filter them by selecting the "Named Versions" option from the drop menu. This will highlight only the renamed versions, along with the current version of the document, making it easy to locate the version you need.

8. Customization Features and Template Options

The web version of Microsoft PowerPoint has limited features compared to the PowerPoint desktop app, which can sometimes be helpful while designing presentations. For example, you can't insert charts or equations in the web version. Additionally, you can't add hyperlinks to pictures or shapes. On the other hand, you can add equations, charts, and hyperlinks to images in Google Slides.

While both platforms offer a good selection of templates, I prefer Google Slides because its templates are user-friendly and easy to customize. It also provides more flexibility when working with themes compared to the web version of PowerPoint.

Google Slides isn't a flawless tool, but for me and many other presentation creators, it not only gets the job done but also has some advantages over PowerPoint. Whether you're a student, team, or regular user, you can use it to make clear and effective presentations.

• Seed and Series A pitch decks
• Series B pitch decks
• Late-stage funding rounds

See the presentations that hot healthcare startups used to raise millions from top VCs

• Startups have raised billions on the promise of disrupting healthcare.
• To win over investors, startups often present their businesses through a slide deck.
• Here are the presentations obtained by Insider that healthcare startups have used to raise millions.

In the past few years, investors have bet billions on healthcare startups looking to disrupt the industry. 

In 2022, that activity cooled off as the market stumbled and companies postponed their public debuts. The slowdown has persisted into 2023, with funding set to fall to the lowest level since 2019, according to Rock Health .

Winning over investors can be a long process, and it often involves a slide deck that lays out what the startup does, and where the company is heading. 

Insider rounded up all the presentations we've published that healthcare startups have used to raise cash from investors. 

Early on, startups sell investors on often newly tested ideas

When startup founders pitch investors ahead of a seed or Series A round, they haven't gotten far off the ground. 

Presentations can be helpful at laying out the how they plan to take on a particular business.

For instance, a dad used this presentation to raise millions to give kids with ADHD and autism the same kind of therapy that helped his son.

And check out the 13-slide presentation heart-health startup Miga Health used to raise $12 million in seed funding . 

Others can use the presentations to share their new approaches. Here's the presentation the former Louisiana health chief used to raise $15 million for her approach to providing care for families at home .

They can also show how a startup might stand out in a competitive field.  Here's the 12-slide presentation Angle Health, a health-insurance startup, used to land $58 million after its public competitors tumbled . 

And Brightside used this presentation to break through a crowded field of mental health startups and convince VCs to invest $24 million.

In 2023, some startups have raised fresh early-stage funds to back different approaches they're trying. For instance, Inato used this 16-slide presentation to raise $20 million after ditching its old product to solve a $50 billion problem for Big Pharma . 

You can see more presentations below.

See the 10-slide presentation a startup used to land $8 million from General Catalyst to speed up medical research with AI

See the 11-slide presentation a startup used to raise $7 million to help patients find new treatments using AI

See the 10-slide presentation a startup used to raise seed funding for a new approach to obesity treatment

See the 17-slide presentation an AI startup used to raise $15 million to improve post-hospital care

See the presentation a digital-health startup used to raise $30 million to bring mental-health care to college students

See the pitch deck a neurosurgeon used to raise $45 million for a new approach to back pain

See the 19-slide presentation that got General Catalyst to back a startup tackling a $25 billion problem for hospitals

Here's the 15-slide presentation Twentyeight Health used to raise $8.3 million to give Medicaid patients better reproductive healthcare

See the 16-slide presentation a startup used to sell investors on a new approach to solving a $50 billion problem for Big Pharma

See the presentation that got General Catalyst to bet $5 million on Disclo, a startup helping people with disabilities get accommodations at work

See the 14-slide pitch deck Labviva used to raise $20 million to overhaul a crucial but overlooked task for Big Pharma

See the 14-slide presentation StationMD used to raise $3.2 million for its approach to providing care online to people with disabilities

See the presentation that convinced Gwyneth Paltrow and NEA to back digital menopause-care startup Evernow

See the 11-slide presentation that convinced General Catalyst to back a startup building a better system to help insurers track their doctors

See the 15-slide presentation a former Googler used to raise $9 million for his new approach to home care

Here's the 17-slide presentation Circles used to raise $16.5 million for group counseling

Here is the 23-slide presentation a former Marie Claire editor-in-chief used to get millennial men to invest in a startup that treats menopause symptoms

Here is the 29-slide presentation a former Cigna executive used to raise $40 million to improve how lower-income older adults receive healthcare

See the 14-slide presentation a members-only concierge emergency-care startup used to raise $30 million in Series A funding

Related stories

Here is the 12-slide presentation that convinced health-tech juggernauts like Anne Wojcicki and Elad Gil to back a public-health-data analytics startup

See the 16-slide presentation a former Uber exec used to raise $25 million to tackle the growing in-home care market

See the 24-slide presentation the Mint founder used to sell investors and hospitals on his new emergency-room management startup

See the presentation a serial entrepreneur used to raise $20 million from Bessemer and Founders Fund for his solution for Americans living with chronic pain

See the presentation a startup used to raise $3.7 million for an entirely new approach to helping millennials plan for their deaths

By Series B, startups are looking for a chance to grow big

By their Series B rounds, startups are raising higher sums at higher valuations. They're often still early into their existence and are looking for ways to get big. 

Health-data startup Carta Healthcare raised $25 million as it navigates a path to profitability. 

And Devoted Health raised $300 million at a $1.8 billion valuation in 2018 before it had signed on any customers. 

Women's healthcare startup Tia used this 30-slide presentation in 2021 to raise $100 million one year after losing all its revenue 'overnight' because of COVID-19. Tia planned to use the funding to expand its in-person clinics in new locations. 

And even amid the 2022 market downturn, Folx Health raised raise $30 million to provide more telehealth options for LGBTQ+ patients with this 17-slide presentation . 

Tomorrow Health, a home-care startup, used this 12-slide presentation to raise $60 million in Series B funding . It's backed by investors including Andreessen Horowitz. 

Meanwhile tech startup Stellar Health raised $60 million from General Atlantic with this presentation with its approach of rewarding doctors for providing better care. 

See the pitch deck Zus Health used to convince top VCs like Andreessen Horowitz, F-Prime, and Maverick to back its solution for healthcare's $140 billion data-sharing problem

See the 29-slide pitch deck that a digital health startup used to raise $24 million entirely from its hospital customers

See the 15-slide presentation Hint Health used to sell its vision of cutting insurance companies out of primary care

See the 17-slide presentation that convinced Livongo's Glen Tullman to invest in a dermatology startup

Here is the 12-slide presentation two academics used to sell investors on their virtual cognitive-testing startup

Alphabet's VC arm just sank $140 million into a startup that wants to unseat dialysis giants like DaVita. We got the pitch deck that convinced CapitalG to back Strive Health.

Late-stage rounds can give startups the fuel to scale or gear up for a public debut

The presentations used to secure later rounds of funding can be used to show investors how far the startup's come, and what's ahead.

Often, the investors start to look different as well, and startups can find themselves pitching asset managers or industry incumbents, like health insurers. 

For instance, Tiger Global and Blackstone backed decentralized trials startup Medable in its Series D .

Tiger Global — alongside health insurer Humana — also backed the at-home healthcare startup Dispatch Health in its Series D . 

And hot mental-health startup NOCD won over investors including Cigna Ventures in January with this presentation .

The later-stage rounds can signal that a company is on the verge of making a major change. In 2023, 98point6 sold its virtual-care service and raised $30.7 million for its pivot to selling software using this pitch deck . 

Meanwhile, Omada Health used this presentation to raise $192 million as it gears up for an IPO . Digital health startup Tebra similarly used this 23-slide presentation to raise $72 million as it prepares to go public . 

Insurer Centene has backed some later-stage rounds, including Hazel Health's Series C and Vida Health's $110 million round. The upstart shared the presentation that helped it raise the funds toward a new vision for the hardest kind of healthcare.

The presentations at this stage can help land startups like Aledade high valuations. Aledade raised $100 million in a round that valued the company at $2.1 billion .

Sometimes, if the founder is well-known, companies might even get unsolicited funding. This happened to Glen Tullman's new startup Transcarent, which raised a $200 million Series C round that valued the company at $1.62 billion.

Here's the 12-slide presentation that convinced Oak HC/FT and Tiger to bet on a virtual-reality startup to train surgeons

See the 13-slide presentation that convinced Oak HC/FT and NEA to bet on a hot primary-care startup

Here's the 11-slide presentation digital-health startup Podimetrics used to land $45 million for its remote-monitoring tech

See the 14-slide presentation that convinced ICONIQ and Sequoia to lead a $140 million investment in a startup focused on treating metabolic conditions

This pitch deck helped telehealth startup Heal raise $100 million and win a major partnership with healthcare giant Humana. Here's how the deal came to be.

Watch: The CEO of one of the largest health insurers in the US explains the problem with healthcare in America

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THE NUCLEOLUS

Jul 19, 2014

1.3k likes | 4.85k Views

THE NUCLEOLUS . The nucleolus ( nucleoli ) non-membrane bound structure composed of proteins and nucleic acids , transcribe ribosomal RNA ( rRNA ) and assemble it within the cell. takes up to about 25% of the nuclear volume. Three major components of the nucleolus are recognized:

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• rrna processing
• nucleolar organizing regions
• rna polymerase
• individual snornps
• abnormal disease processes

Presentation Transcript

THE NUCLEOLUS The nucleolus (nucleoli) non-membrane bound structure composed of proteins and nucleic acids , transcriberibosomal RNA (rRNA) and assemble it within the cell. takes up to about 25% of the nuclear volume. Three major components of the nucleolus are recognized: • the fibrillar centers (FC), • The DFC or pars fibrosaconsists of newly transcribed rRNA bound to ribosomal proteins • granular component (GC) pars granulosa, contains RNA bound to ribosomal proteins that are beginning to assemble into ribosome. These different regions are thought to represent the sites of progressive stages of rRNAtranscription, processing, and ribosome assembly.

The rRNA genes are located in the fibrillar centers, with transcription occurring primarily at the boundary of the fibrillar centers and dense fibrillar component. Processing of the pre-rRNA is initiated in the dense fibrillar component and continues in the granular component, where the rRNA is assembled with ribosomal proteins to form nearly completed preribosomal subunits, ready for export to the cytoplasm. • Another structure identified within many nucleoli (particularly in plants) is a clear area in the center of the structure referred to as a nucleolar vacuole. • Nucleoli of various plant species have been shown to have very high concentrations of iron in contrast to human and animal cell nucleoli.

ORGANIZATION Nucleoli are formed around specific genetic loci called nucleolar organizing regions (NORs), NOR is composed of tandem repeats of rRNA genes. The human genome contains more than 200 clustered copies of the rRNA genes on five different chromosomes (13, 14, 15, 21, 22). • In ribosome biogenesis, two of the three eukaryotic RNA polymerases (pol I and III) are required, and these function in a coordinated manner.

RIBOSOMAL BIOGENESIS cleavage within the external transcribed spacer near the 5′ end of the (45S) pre-rRNA, which takes place during the early stages of transcription.requires the U3 small nucleolar RNP Once transcription is complete, the external transcribed spacer at the 3′ end of the molecule is removed. cleavage at the 5′ end of the 5.8S region, yielding separate precursors to the 18S and 5.8S + 28S rRNAs. Additional cleavages then result in formation of the mature rRNAs. Processing follows a similar pattern in other species, although there are differences in the order of some of the cleavages. U3, nucleolar RNP

Nucleoli contain a large number (about 200) of small nucleolar RNAs (snoRNAs) that function in pre-rRNA processing. Like the spliceosomalsnRNAs, the snoRNAs are complexed with proteins, forming snoRNPs. Individual snoRNPs consist of single snoRNAs associated with eight to ten proteins. The snoRNPs then assemble on the pre-rRNA to form processing complexes ……U3 U5 U22 etc The snoRNAs contain short sequences complementary to rRNA. Base pairing between snoRNAs and pre-rRNA targets the enzymes that catalyze base modification (e.g., methylation, splicing etc) to the appropriate sites on pre-rRNA

Ribosome Assembly 1- ribosomal proteins : RNA polymerase II, 2-5S rRNA : RNA polymerase III

NUCLEOLAR SEQUESTRATION The nucleolus is known to capture and immobilize proteins, then are unable to diffuse and to interact with their binding partners. Targets of this post-translational regulatory mechanism include hTERT. It is now known that noncoding RNAs originating from intergenic regions of the nucleolus are responsible for this phenomenon.

SUB NUCLEAR BODIES Cajal bodies, Gemini of coiled bodies, Polymorphic interphasekaryosomal association (pika) Promyelocytic leukaemia (PML) bodies, Paraspeckles, Splicing speckles. as part of abnormal disease processes. NEMALINE MYOPATHY: the presence of small intranuclear rods has been reported , mutations in actin, and the rods themselves consist of mutant actin as well as other cytoskeletal proteins.

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