how to make a synthesis in research paper

How to Synthesize Written Information from Multiple Sources

Shona McCombes

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B.A., English Literature, University of Glasgow

Shona McCombes is the content manager at Scribbr, Netherlands.

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Saul Mcleod, PhD

Editor-in-Chief for Simply Psychology

BSc (Hons) Psychology, MRes, PhD, University of Manchester

Saul Mcleod, PhD., is a qualified psychology teacher with over 18 years of experience in further and higher education. He has been published in peer-reviewed journals, including the Journal of Clinical Psychology.

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When you write a literature review or essay, you have to go beyond just summarizing the articles you’ve read – you need to synthesize the literature to show how it all fits together (and how your own research fits in).

Synthesizing simply means combining. Instead of summarizing the main points of each source in turn, you put together the ideas and findings of multiple sources in order to make an overall point.

At the most basic level, this involves looking for similarities and differences between your sources. Your synthesis should show the reader where the sources overlap and where they diverge.

Unsynthesized Example

Franz (2008) studied undergraduate online students. He looked at 17 females and 18 males and found that none of them liked APA. According to Franz, the evidence suggested that all students are reluctant to learn citations style. Perez (2010) also studies undergraduate students. She looked at 42 females and 50 males and found that males were significantly more inclined to use citation software ( p < .05). Findings suggest that females might graduate sooner. Goldstein (2012) looked at British undergraduates. Among a sample of 50, all females, all confident in their abilities to cite and were eager to write their dissertations.

Synthesized Example

Studies of undergraduate students reveal conflicting conclusions regarding relationships between advanced scholarly study and citation efficacy. Although Franz (2008) found that no participants enjoyed learning citation style, Goldstein (2012) determined in a larger study that all participants watched felt comfortable citing sources, suggesting that variables among participant and control group populations must be examined more closely. Although Perez (2010) expanded on Franz’s original study with a larger, more diverse sample…

Step 1: Organize your sources

After collecting the relevant literature, you’ve got a lot of information to work through, and no clear idea of how it all fits together.

Before you can start writing, you need to organize your notes in a way that allows you to see the relationships between sources.

One way to begin synthesizing the literature is to put your notes into a table. Depending on your topic and the type of literature you’re dealing with, there are a couple of different ways you can organize this.

Summary table

A summary table collates the key points of each source under consistent headings. This is a good approach if your sources tend to have a similar structure – for instance, if they’re all empirical papers.

Each row in the table lists one source, and each column identifies a specific part of the source. You can decide which headings to include based on what’s most relevant to the literature you’re dealing with.

For example, you might include columns for things like aims, methods, variables, population, sample size, and conclusion.

For each study, you briefly summarize each of these aspects. You can also include columns for your own evaluation and analysis.

The summary table gives you a quick overview of the key points of each source. This allows you to group sources by relevant similarities, as well as noticing important differences or contradictions in their findings.

Synthesis matrix

A synthesis matrix is useful when your sources are more varied in their purpose and structure – for example, when you’re dealing with books and essays making various different arguments about a topic.

Each column in the table lists one source. Each row is labeled with a specific concept, topic or theme that recurs across all or most of the sources.

Then, for each source, you summarize the main points or arguments related to the theme.

The purposes of the table is to identify the common points that connect the sources, as well as identifying points where they diverge or disagree.

Step 2: Outline your structure

Now you should have a clear overview of the main connections and differences between the sources you’ve read. Next, you need to decide how you’ll group them together and the order in which you’ll discuss them.

For shorter papers, your outline can just identify the focus of each paragraph; for longer papers, you might want to divide it into sections with headings.

There are a few different approaches you can take to help you structure your synthesis.

If your sources cover a broad time period, and you found patterns in how researchers approached the topic over time, you can organize your discussion chronologically .

That doesn’t mean you just summarize each paper in chronological order; instead, you should group articles into time periods and identify what they have in common, as well as signalling important turning points or developments in the literature.

If the literature covers various different topics, you can organize it thematically .

That means that each paragraph or section focuses on a specific theme and explains how that theme is approached in the literature.

Source Used with Permission: The Chicago School

If you’re drawing on literature from various different fields or they use a wide variety of research methods, you can organize your sources methodologically .

That means grouping together studies based on the type of research they did and discussing the findings that emerged from each method.

If your topic involves a debate between different schools of thought, you can organize it theoretically .

That means comparing the different theories that have been developed and grouping together papers based on the position or perspective they take on the topic, as well as evaluating which arguments are most convincing.

Step 3: Write paragraphs with topic sentences

What sets a synthesis apart from a summary is that it combines various sources. The easiest way to think about this is that each paragraph should discuss a few different sources, and you should be able to condense the overall point of the paragraph into one sentence.

This is called a topic sentence , and it usually appears at the start of the paragraph. The topic sentence signals what the whole paragraph is about; every sentence in the paragraph should be clearly related to it.

A topic sentence can be a simple summary of the paragraph’s content:

“Early research on [x] focused heavily on [y].”

For an effective synthesis, you can use topic sentences to link back to the previous paragraph, highlighting a point of debate or critique:

“Several scholars have pointed out the flaws in this approach.” “While recent research has attempted to address the problem, many of these studies have methodological flaws that limit their validity.”

By using topic sentences, you can ensure that your paragraphs are coherent and clearly show the connections between the articles you are discussing.

As you write your paragraphs, avoid quoting directly from sources: use your own words to explain the commonalities and differences that you found in the literature.

Don’t try to cover every single point from every single source – the key to synthesizing is to extract the most important and relevant information and combine it to give your reader an overall picture of the state of knowledge on your topic.

Step 4: Revise, edit and proofread

Like any other piece of academic writing, synthesizing literature doesn’t happen all in one go – it involves redrafting, revising, editing and proofreading your work.

Checklist for Synthesis

•   Do I introduce the paragraph with a clear, focused topic sentence?
•   Do I discuss more than one source in the paragraph?
•   Do I mention only the most relevant findings, rather than describing every part of the studies?
•   Do I discuss the similarities or differences between the sources, rather than summarizing each source in turn?
•   Do I put the findings or arguments of the sources in my own words?
•   Is the paragraph organized around a single idea?
•   Is the paragraph directly relevant to my research question or topic?
•   Is there a logical transition from this paragraph to the next one?

Further Information

How to Synthesise: a Step-by-Step Approach

Help…I”ve Been Asked to Synthesize!

Learn how to Synthesise (combine information from sources)

How to write a Psychology Essay

How to Write a Synthesis Essay

Synthesis essays are common assignments in both high school and university, but that doesn’t mean they’re easy or that everyone knows how to write them. In this guide, we discuss everything you need to know in order to write one yourself. We talk about synthesis essay structure and offer some general tips, plus we clarify any confusion between a synthesis essay versus an argumentative essay.

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What is a synthesis essay?

A synthesis essay is a type of essay that combines points, data, and evidence from multiple sources and turns them into one idea that the writing revolves around. In other words, the writer synthesizes their own idea using other sources’ research and points. Usually, synthesis essays are a type of analytical essay , but they have crossover with other types of essays as well, such as argumentative essays .

The central idea in a synthesis essay is represented by the thesis statement , a sentence that succinctly explains the main point of the essay. In a synthesis essay, this “new” idea usually consolidates the main points and/or findings of other sources.

Synthesis essay structure

Creating a solid synthesis essay structure is one of the hardest parts of writing a synthesis essay. Unlike most other essay outlines , an outline for a synthesis essay has to include points from multiple sources, and such combinations don’t always have a logical or chronological sequence. To help you out, here are three strategies for creating a synthesis essay structure and sample outlines that you can use as templates.

Synthesis essay structure 1: By topic

The first kind of synthesis essay structure involves discussing each topic individually, mentioning each source’s perspective on it, and then moving on to the next topic. This approach lets you compare or join together points made by different sources about the same specific topic.

Structuring your synthesis essay by topic works best for more complicated ideas with different aspects that should be explored individually.

Example outline:

I. Introduction A. Thesis statement

II. Topic 1 A. Source A discussing Topic 1 1. A point or piece of evidence/data from Source A about Topic 1 2. Another point or piece of evidence/data from Source A about Topic 1 3. [Etc.]

B. Source B discussing Topic 1 1. A point or piece of evidence/data from Source B about Topic 1 2. [Etc.] 

III. Topic 2 A. Source A discussing Topic 2 B. [Etc.] 

IV. Topic 3 A. [Etc.]

[You can keep going like this with as many topics as you need.]

V. Conclusion A. Revisit thesis statement

Synthesis essay structure 2: By source

Alternatively, you can organize your synthesis essay structure by source: You discuss the main points of one source together and then move on to another source. This approach lets you compartmentalize the main points according to where they come from but ultimately bring together the main points from different sources.

Structuring your synthesis essay by source works best when you want to emphasize the sources themselves over the points they make. For example, if you were using this type of structure for an argumentative essay, you might want to fully discuss the source you’re refuting before making your counterargument.

II. Source 1 A. Source 1 discussing Topic A 1. A point or piece of evidence/data from Source 1 about Topic A 2. Another point or piece of evidence/data from Source 1 about Topic A 3. [Etc.]

B. Source 1 discussing Topic B 1. A point or piece of evidence/data from Source 1 about Topic B 2. [Etc.]

III. Source 2 A. Source 2 discussing Topic A B. Source 2 discussing Topic B C. [Etc.]

IV. Source 3 A. [Etc.]

[You can keep going like this for all your sources.]

V. Conclusion 1. Revisit thesis statement

Synthesis essay structure 3: Combine

The synthesis essay structures above are by no means set in stone. You’re free to adapt or modify them however you need and can even combine them.

For example, what if there’s a special source that stands out from the others? You could begin your synthesis essay by discussing each topic individually so that your reader understands the issue. Then you could switch it up and include a section just for that one special source, explaining that source’s stance on the previously discussed topics.

3 tips for writing a synthesis essay

1 come up with a strong thesis statement.

As mentioned above, a thesis statement is a single sentence that briefly explains the main point of your essay. In a synthesis essay, the thesis statement should effectively bring together the ideas and points from multiple other sources.

Part of writing a strong thesis statement comes from choosing your essay topic . Pick a topic that is broad enough to have sufficient research and enough other sources discussing it but specific enough that you can cover everything.

As for writing the actual thesis statement, a helpful method is to phrase your topic as a question and then answer it. The answer could be a good start to your thesis statement sentence. For example, let’s say your topic is how Denmark came to be first in clean energy. You could phrase the question and answer as:

Q: “Why is Denmark the leading country in renewable energy?”

A: “Denmark is first in clean energy thanks in part to energy conservation from district heating, combined heat-and-power stations, and its use of small, locally based power plants instead of larger ones.”

That answer could double as your thesis statement and mentions some of the other types of sources you use in your essay.

2 Read all the sources carefully

A synthesis essay is only as good as its sources. The nature of a synthesis essay is to build on its sources, so you need to choose the best ones and understand each of them thoroughly.

Make sure you comb through your sources so you don’t miss a good point or piece of evidence you could use in your essay. It helps to come up with your thesis statement early on so you can look for points related to it when you’re reading.

3 Write a gripping introduction

One of the keys to any good essay, synthesis or not, is a strong opening. This is partially determined by your thesis statement, but the other sentences in your introduction also make a big impact.

For starters, you can learn how to write a hook . In writing, a hook is something that grabs the reader’s attention and makes them want to keep reading. Hooks can essentially be anything interesting. Some common strategies for writing hooks include using personal anecdotes to create an emotional connection or providing exciting facts/statistics that the reader might not know.

Additionally, the introduction should also explain the scope of your topic and set the scene for people who aren’t familiar with it. The goal of the introduction is to prepare the reader for what follows so that afterward you can transition straight into making your points.

Synthesis essay vs. argumentative essay

Synthesis essays are often compared to argumentative essays, which attempt to refute, debunk, or criticize existing ideas or other research. The truth is that the two are not mutually exclusive. Although synthesis essays tend to be analytical or expository, they can also be argumentative.

A synthesis essay is any essay that combines ideas from multiple sources to create a new unified idea. If that new idea is a rebuttal to a preexisting idea and the entire essay is written as a critique, then the essay would be both synthesis and argumentative.

Synthesis essay FAQs

A synthesis essay is a type of essay that combines points, data, and evidence from multiple sources and turns them into one unified idea. In other words, the writer synthesizes their own idea using other sources’ research and ideas.

What is a good synthesis essay structure?

Traditionally, the common approaches to creating a synthesis essay structure are organizing by topic or organizing by source. The former means you discuss each source’s perspective on a topic before moving to the next topic; the latter means you discuss one source’s stance on each topic and then move to another source. You can also create a hybrid structure of the two for particular subjects.

What is the difference between a synthesis essay and an argumentative essay?

Synthesis essays are often contrasted with argumentative essays, but the truth is that the two are not mutually exclusive. For example, an argumentative essay can use the format of a synthesis essay—combining points from multiple sources to form a new unified idea—in order to refute a preexisting idea.

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How to Write a Literature Review

• 6. Synthesize
• Literature Reviews: A Recap
• Reading Journal Articles
• Does it Describe a Literature Review?
• 1. Identify the Question
• 2. Review Discipline Styles
• Searching Article Databases
• Finding Full-Text of an Article
• Citation Chaining
• When to Stop Searching
• 4. Manage Your References
• 5. Critically Analyze and Evaluate

Synthesis Visualization

Synthesis matrix example.

• 7. Write a Literature Review

• Synthesis Worksheet

About Synthesis

Approaches to synthesis.

You can sort the literature in various ways, for example:

How to Begin?

Read your sources carefully and find the main idea(s) of each source

Look for similarities in your sources – which sources are talking about the same main ideas? (for example, sources that discuss the historical background on your topic)

Use the worksheet (above) or synthesis matrix (below) to get organized

This work can be messy. Don't worry if you have to go through a few iterations of the worksheet or matrix as you work on your lit review!

Four Examples of Student Writing

In the four examples below, only ONE shows a good example of synthesis: the fourth column, or  Student D . For a web accessible version, click the link below the image.

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• Download a copy of the "Four Examples of Student Writing" chart

Click on the example to view the pdf.

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How to Write a Synthesis Essay: Your Guide From Start to Finish

Today, we're swamped with information, like reading 174 newspapers every day. It comes from all over—news, social media, science, and more. This flood might make you feel overwhelmed and lost in a sea of facts and opinions. But being able to make sense of it all is crucial.

This guide isn't just about handling all that info; it's about using it to write awesome essays. We'll show you step by step how to pick a topic and organize your essay. Let's dive in and learn how to turn scattered facts into powerful essays that really stand out.

What Is a Synthesis Essay

The synthesis essay is a powerful tool in writing. It's not just about gathering facts but about connecting them to make a clear and strong argument.

Writing a synthesis essay allows you to dive deep into ideas. You have to find similarities between different sources—like articles, studies, or arguments—and use them to tell a convincing story.

In today's world, where we're bombarded with information, synthesis essays are more important than ever. They let us explore how different ideas fit together and help us express our thoughts on complex topics. Whether you're writing about literature, science, history, or current events, a synthesis essay shows off your ability to analyze and understand a topic from all angles. And if you're struggling with this task, just ask us to ' write paper for me ,' and we'll handle your assignment for you.

Explanatory vs. Argumentative Synthesis Essays

In synthesis writing, there are two main types: explanatory and argumentative. Understanding these categories is key because they shape how you approach your essay.

Explanatory:

An explanatory synthesis essay does just what it says—it explains. These essays aim to give a balanced view of a topic by gathering information from different sources and presenting it clearly. They don't try to persuade; instead, they focus on providing information and making things easier to understand. They're like comprehensive summaries, breaking down complex ideas for a broader audience. These essays rely heavily on facts and expert opinions, avoiding personal bias.

Argumentative:

On the flip side, argumentative synthesis essays are all about persuasion. Their main goal is to take a stance on an issue and convince the reader. They gather information from various sources not only to present different views but also to build a strong argument. Argumentative essays aim to sway the reader's opinion by using gathered information as evidence. These essays express opinions and use rhetorical strategies to persuade.

And if you're keen on knowing how to write an informative essay , we've got you covered on that, too!

Synthesis Essay Structure

To craft a strong synthesis essay, you need a solid foundation. Here's a structured approach to help you nail it:

Introductory Paragraph:

• To kick things off, grab your reader's attention with a catchy hook or interesting fact. Give a bit of background info about your topic and the sources you'll be using, as it can help readers understand your topic better! Then, lay out your main argument in a clear thesis statement.

Body Paragraphs:

• Each paragraph should focus on a different aspect of your topic or source. Start with a topic sentence that links back to your thesis. Introduce the source you're discussing and highlight its main points. Also, using quotes, paraphrases, or summaries from your sources can make your arguments stronger.

Synthesis :

• This part is where your essay comes together. Look for common themes or differences among your sources. Use your analysis to build a strong argument. Don't forget to address any opposing viewpoints if they're relevant!

Conclusion :

• Wrap things up by restating your thesis and summarizing your main points. Explain why your argument is important and what it means in the bigger picture. End with a thought-provoking statement to leave a lasting impression.

References :

• Finally, don't forget to list all your sources properly using the right citation style, like MLA or APA. Do you know that different citation styles have different rules? So, make sure you follow the right one!

Choosing a Synthesis Essay Topic

Picking essay topics is just the beginning. To write a great synthesis essay, you need to carefully evaluate and connect different sources to build a strong argument or viewpoint. Here's a step-by-step infographic guide to help you choose the right synthesis essay topics wisely.

How to Write a Synthesis Essay with Easy Steps

Writing a synthesis essay is similar to a compare and contrast essay . It requires a methodical approach to blend information from different sources into a strong and persuasive argument. Here are some crucial steps and tips to help you along the way.

• Clarify Your Purpose: First, decide if you're writing an explanatory or argumentative synthesis essay. This choice will set the tone and direction for your essay.
• Source Selection and Analysis: Choose credible and relevant sources for your topic, balancing different types like articles, books, and websites. Analyze each source carefully, noting the main ideas and evidence presented.
• Formulate a Strong Thesis Statement: Create a clear and concise thesis statement that guides your essay. It should express your main argument or perspective.
• Structure Your Essay: Organize your essay with a clear synthesis essay outline, including an introduction, body paragraphs, and a conclusion. Each body paragraph should focus on a specific aspect of your topic.
• Employ Effective Transition Sentences: Use transition sentences to connect your ideas and paragraphs smoothly, ensuring a cohesive flow in your essay.
• Synthesize Information: Blend information from your sources within your paragraphs. Discuss how each source contributes to your thesis and highlight common themes or differences.
• Avoid Simple Summarization: Don't just summarize your sources—analyze them critically and use them to build your argument.
• Address Counterarguments (if applicable): Acknowledge opposing viewpoints and counter them with well-supported arguments, showing a deep understanding of the topic.
• Craft a Resolute Conclusion: Summarize your main points and restate your thesis in the conclusion. Emphasize the importance of your argument or insights, and end with a thought-provoking statement or call to action. ‍
• Revise and Proofread: Check your essay for clarity, coherence, and grammar mistakes. Ensure your citations are correct and follow the chosen citation style, like MLA or APA.

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Synthesis Essay Format

Choosing the right citation style can enhance the credibility and professionalism of your paper. The format of your synthesis paper depends on the specific guidelines given by your instructor. They usually fall into one of the popular styles: MLA, APA, or Chicago, each used in different academic fields.

1. MLA (Modern Language Association):

• Uses in-text citations with the author's last name and page number.
• Includes a 'Works Cited' page at the end listing all sources.
• Focuses on the author and publication date.
• Often used in humanities essays, research papers, and literary analyses.

2. APA (American Psychological Association):

• Uses in-text citations with the author's last name and publication date in parentheses.
• Includes a 'References' page listing all sources alphabetically.
• Emphasizes the publication date and scientific precision.
• Commonly used in research papers, scholarly articles, and scientific studies.

3. Chicago Style:

• Offers two documentation styles: Notes-Bibliography and Author-Date.
• Notes-Bibliography uses footnotes or endnotes for citations, while Author-Date uses in-text citations with a reference list.
• Suitable for various academic writing, including research papers and historical studies.
• Provides flexibility in formatting and citation methods, making it adaptable to different disciplines.

Synthesis Essay Example

Here are two examples of synthesis essays that demonstrate how to apply the synthesis process in real life. They explore interesting topics and offer practical guidance for mastering the art of writing this type of paper.

Synthesis Essay Tips

Crafting a strong synthesis essay requires careful planning and effective techniques. Here are five essential tips to help you write your best paper:

• Diverse Source Selection : Choose a range of reliable sources that offer different viewpoints on your topic. Make sure they're recent and relevant to your subject.
• Seamless Source Integration : Avoid just summarizing your sources. Instead, blend them into your essay by analyzing and comparing their ideas. Show how they connect to build your argument.
• Balanced Tone : Maintain an impartial tone in your writing, even if you have personal opinions. Synthesis essays require objectivity, so they present different viewpoints without bias.
• Focus on Synthesis : Remember, synthesis essays are about linking ideas, not just summarizing sources. Explore how your sources relate to each other to create a cohesive argument.
• Address Counterarguments : Like in persuasive essays topics , acknowledge opposing viewpoints and explain why your perspective is stronger. This demonstrates your understanding of the topic and adds depth to your argument.

Concluding Thoughts

When writing a synthesis essay, it's essential to pick trustworthy sources, blend them effectively to build your argument and stay objective. Use smooth transitions, address counterarguments thoughtfully, and focus on analyzing rather than just summarizing. By following these steps, you'll create essays that inform, persuade, and engage your readers!

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How Should You Conclude a Synthesis Essay?

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In a synthesis, you bring things together. This combination, integration, or merging creates something new--your synthesis. The action of synthesis is basic to our world. Take, for example, what happens when a single oxygen molecule is combined with two hydrogen molecules. Water is created or synthesized. Hard to get more basic than that.

You also use synthesis to make personal decisions. If two instructors are teaching a class you must take, you may synthesize your past experiences with the teachers to choose the best class for you.

Research Essays:

Thesis driven.

In school, when writing a synthesis from your research, your sources may come from the school's library, a textbook, or the Internet. Here are some important points to keep in mind:

First, regardless of where your sources come from or how many you have, what you write should be driven by a thesis that you devise. After reading and studying your sources, you should form a personal point of view, a slant to connect your sources.

Here's a quick example--Let's say you've read three folktales: Goldilocks and the Three Bears, Little Red Riding Hood, and the Pied Piper--and now you must write a synthesis of them. As you study the three sources, you think about links between them and come up with this thesis: 

Folktales use fear to teach children lessons.

Then you use this thesis to synthesize your three sources as you support your point of view. You combine elements from the three sources to prove and illustrate this thesis. Your support points could focus on the lessons for children:

• Lesson 1 : Never talk to strangers.
• Lesson 2 : Don't wander from home.
• Lesson 3 : Appearances can deceive us.

This step of outlining your thesis and main points is a crucial one when writing a synthesis. If your goal in writing a research essay is to provide readers a unified perspective based on sources, the unified perspective must be clear before the writing begins.

Once the writing begins, your point of view is then carried through to the paragraph and sentence levels. Let's examine some techniques for achieving the unity that a good synthesis requires. First, here’s an example of an unsuccessful attempt at synthesizing sources:

Many sources agree that capital punishment is not a crime deterrent. [This is the idea around which the sources should be unified. Now comes the sources] According to Judy Pennington in an interview with Helen Prejean, crime rates in New Orleans rise for at least eight weeks following executions (110). Jimmy Dunne notes that crime rates often go up in the first two or three months following an execution. “Death in the Americas” argues that America’s crime rate as a whole has increased drastically since the re-instatement of the death penalty in the 1960s. The article notes that 700 crimes are committed for every 100,000 Americans (2). Helen Prejean cites Ellis in her book to note that in 1980, 500,000 people were behind bars and in 1990 that figure rose to 1.1 million (112).

Sample student paragraph adapted from "Literature Review: Synthesizing Multiple Sources." Retrieved 2011 from https://scholarworks.iupui.edu/items/7dda80e7-b0b3-477c-a972-283b48cfdf5c

This paragraph certainly uses a number of sources. However, the sources are presented in a random, grocery list fashion. Besides the main point at the beginning, there is no further attempt to synthesize. The sources seem tossed in, like ingredients in a salad. Let's examine a possible revision of that paragraph and how an adequate synthesis might be achieved:

Major studies suggest that capital punishment fails to deter crime. Helen Prejean, in "Deadman Walking," reviews decades of statistics that indicate capital punishment does little to lower crime. [Key idea from  topic sentence—"capital punishment fails to deter crime"— echoed in sentence about source–"capital punishment does little to lower crime." Repetition links source to main idea.] Based on this evidence, Prejean concludes “Executions do not deter crime . . . the U.S. murder rate is no higher in states that do not have the death penalty than those who do” (110). ["Based on this evidence" forces  reader to refer back to "statistics" in previous sentence.] Prejean’s point is reiterated from a historical perspective in Dunne's article “Death in the Americas.”  [This sentence provides a thought bridge between two sources.] Dunne first points out that, despite the social and economic upheavals from 1930 to 1960, crime rates were unchanged (2). [Linking phrase:"Dunne first points out"] However, after the reinstatement of the death penalty in the 1960s, “crime rates soared” (2). [Linking phase "However, Dunne notes."]

The result is a matrix of connective devices that unifies the sources around a key idea stated at the beginning. Although this matrix seems complex, it is actually built on a simple three-point strategy.

• Stay in charge . You the writer must control the sources, using them to serve your purpose. In good synthesis writing, sources are used to support what you, the writer, have already said in your own words.
• Stay focused . Your main point is not merely stated once and left to wilt. Your main idea is repeated and echoed throughout as a way to link the sources, to weave them together into a strong fabric of meaning.
• Stay strategic . Notice the "source sandwich" strategy at work. First, the author sets up the source with its background and relevance to the point. After the source comes a follows up in his/her own words as a way to bridge or link to the next part. In other words, the writer's own words are used like two slices of bread, with the source in the middle.

Follow these simple principles when using sources in your writing and you will achieve the most important goal of synthesis writing--to create a whole greater than its parts.

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Literature Syntheis 101

How To Synthesise The Existing Research (With Examples)

By: Derek Jansen (MBA) | Expert Reviewer: Eunice Rautenbach (DTech) | August 2023

One of the most common mistakes that students make when writing a literature review is that they err on the side of describing the existing literature rather than providing a critical synthesis of it. In this post, we’ll unpack what exactly synthesis means and show you how to craft a strong literature synthesis using practical examples.

This post is based on our popular online course, Literature Review Bootcamp . In the course, we walk you through the full process of developing a literature review, step by step. If it’s your first time writing a literature review, you definitely want to use this link to get 50% off the course (limited-time offer).

Overview: Literature Synthesis

• What exactly does “synthesis” mean?
• Aspect 1: Agreement
• Aspect 2: Disagreement
• Aspect 3: Key theories
• Aspect 4: Contexts
• Aspect 5: Methodologies
• Bringing it all together

What does “synthesis” actually mean?

As a starting point, let’s quickly define what exactly we mean when we use the term “synthesis” within the context of a literature review.

Simply put, literature synthesis means going beyond just describing what everyone has said and found. Instead, synthesis is about bringing together all the information from various sources to present a cohesive assessment of the current state of knowledge in relation to your study’s research aims and questions .

Put another way, a good synthesis tells the reader exactly where the current research is “at” in terms of the topic you’re interested in – specifically, what’s known , what’s not , and where there’s a need for more research .

So, how do you go about doing this?

Well, there’s no “one right way” when it comes to literature synthesis, but we’ve found that it’s particularly useful to ask yourself five key questions when you’re working on your literature review. Having done so,  you can then address them more articulately within your actual write up. So, let’s take a look at each of these questions.

1. Points Of Agreement

The first question that you need to ask yourself is: “Overall, what things seem to be agreed upon by the vast majority of the literature?”

For example, if your research aim is to identify which factors contribute toward job satisfaction, you’ll need to identify which factors are broadly agreed upon and “settled” within the literature. Naturally, there may at times be some lone contrarian that has a radical viewpoint , but, provided that the vast majority of researchers are in agreement, you can put these random outliers to the side. That is, of course, unless your research aims to explore a contrarian viewpoint and there’s a clear justification for doing so. 

Identifying what’s broadly agreed upon is an essential starting point for synthesising the literature, because you generally don’t want (or need) to reinvent the wheel or run down a road investigating something that is already well established . So, addressing this question first lays a foundation of “settled” knowledge.

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2. Points Of Disagreement

Related to the previous point, but on the other end of the spectrum, is the equally important question: “Where do the disagreements lie?” .

In other words, which things are not well agreed upon by current researchers? It’s important to clarify here that by disagreement, we don’t mean that researchers are (necessarily) fighting over it – just that there are relatively mixed findings within the empirical research , with no firm consensus amongst researchers.

This is a really important question to address as these “disagreements” will often set the stage for the research gap(s). In other words, they provide clues regarding potential opportunities for further research, which your study can then (hopefully) contribute toward filling. If you’re not familiar with the concept of a research gap, be sure to check out our explainer video covering exactly that .

3. Key Theories

The next question you need to ask yourself is: “Which key theories seem to be coming up repeatedly?” .

Within most research spaces, you’ll find that you keep running into a handful of key theories that are referred to over and over again. Apart from identifying these theories, you’ll also need to think about how they’re connected to each other. Specifically, you need to ask yourself:

• Are they all covering the same ground or do they have different focal points  or underlying assumptions ?
• Do some of them feed into each other and if so, is there an opportunity to integrate them into a more cohesive theory?
• Do some of them pull in different directions ? If so, why might this be?
• Do all of the theories define the key concepts and variables in the same way, or is there some disconnect? If so, what’s the impact of this ?

Simply put, you’ll need to pay careful attention to the key theories in your research area, as they will need to feature within your theoretical framework , which will form a critical component within your final literature review. This will set the foundation for your entire study, so it’s essential that you be critical in this area of your literature synthesis.

If this sounds a bit fluffy, don’t worry. We deep dive into the theoretical framework (as well as the conceptual framework) and look at practical examples in Literature Review Bootcamp . If you’d like to learn more, take advantage of our limited-time offer to get 60% off the standard price.

4. Contexts

The next question that you need to address in your literature synthesis is an important one, and that is: “Which contexts have (and have not) been covered by the existing research?” .

For example, sticking with our earlier hypothetical topic (factors that impact job satisfaction), you may find that most of the research has focused on white-collar , management-level staff within a primarily Western context, but little has been done on blue-collar workers in an Eastern context. Given the significant socio-cultural differences between these two groups, this is an important observation, as it could present a contextual research gap .

In practical terms, this means that you’ll need to carefully assess the context of each piece of literature that you’re engaging with, especially the empirical research (i.e., studies that have collected and analysed real-world data). Ideally, you should keep notes regarding the context of each study in some sort of catalogue or sheet, so that you can easily make sense of this before you start the writing phase. If you’d like, our free literature catalogue worksheet is a great tool for this task.

5. Methodological Approaches

Last but certainly not least, you need to ask yourself the question: “What types of research methodologies have (and haven’t) been used?”

For example, you might find that most studies have approached the topic using qualitative methods such as interviews and thematic analysis. Alternatively, you might find that most studies have used quantitative methods such as online surveys and statistical analysis.

But why does this matter?

Well, it can run in one of two potential directions . If you find that the vast majority of studies use a specific methodological approach, this could provide you with a firm foundation on which to base your own study’s methodology . In other words, you can use the methodologies of similar studies to inform (and justify) your own study’s research design .

On the other hand, you might argue that the lack of diverse methodological approaches presents a research gap , and therefore your study could contribute toward filling that gap by taking a different approach. For example, taking a qualitative approach to a research area that is typically approached quantitatively. Of course, if you’re going to go against the methodological grain, you’ll need to provide a strong justification for why your proposed approach makes sense. Nevertheless, it is something worth at least considering.

Regardless of which route you opt for, you need to pay careful attention to the methodologies used in the relevant studies and provide at least some discussion about this in your write-up. Again, it’s useful to keep track of this on some sort of spreadsheet or catalogue as you digest each article, so consider grabbing a copy of our free literature catalogue if you don’t have anything in place.

Bringing It All Together

Alright, so we’ve looked at five important questions that you need to ask (and answer) to help you develop a strong synthesis within your literature review.  To recap, these are:

• Which things are broadly agreed upon within the current research?
• Which things are the subject of disagreement (or at least, present mixed findings)?
• Which theories seem to be central to your research topic and how do they relate or compare to each other?
• Which contexts have (and haven’t) been covered?
• Which methodological approaches are most common?

Importantly, you’re not just asking yourself these questions for the sake of asking them – they’re not just a reflection exercise. You need to weave your answers to them into your actual literature review when you write it up. How exactly you do this will vary from project to project depending on the structure you opt for, but you’ll still need to address them within your literature review, whichever route you go.

The best approach is to spend some time actually writing out your answers to these questions, as opposed to just thinking about them in your head. Putting your thoughts onto paper really helps you flesh out your thinking . As you do this, don’t just write down the answers – instead, think about what they mean in terms of the research gap you’ll present , as well as the methodological approach you’ll take . Your literature synthesis needs to lay the groundwork for these two things, so it’s essential that you link all of it together in your mind, and of course, on paper.

Psst… there’s more!

This post is an extract from our bestselling short course, Literature Review Bootcamp . If you want to work smart, you don't want to miss this .

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Using Evidence: Synthesis

Synthesis video playlist.

Note that these videos were created while APA 6 was the style guide edition in use. There may be some examples of writing that have not been updated to APA 7 guidelines.

Basics of Synthesis

As you incorporate published writing into your own writing, you should aim for synthesis of the material.

Synthesizing requires critical reading and thinking in order to compare different material, highlighting similarities, differences, and connections. When writers synthesize successfully, they present new ideas based on interpretations of other evidence or arguments. You can also think of synthesis as an extension of—or a more complicated form of—analysis. One main difference is that synthesis involves multiple sources, while analysis often focuses on one source.

Conceptually, it can be helpful to think about synthesis existing at both the local (or paragraph) level and the global (or paper) level.

Local Synthesis

Local synthesis occurs at the paragraph level when writers connect individual pieces of evidence from multiple sources to support a paragraph’s main idea and advance a paper’s thesis statement. A common example in academic writing is a scholarly paragraph that includes a main idea, evidence from multiple sources, and analysis of those multiple sources together.

Global Synthesis

Global synthesis occurs at the paper (or, sometimes, section) level when writers connect ideas across paragraphs or sections to create a new narrative whole. A literature review , which can either stand alone or be a section/chapter within a capstone, is a common example of a place where global synthesis is necessary. However, in almost all academic writing, global synthesis is created by and sometimes referred to as good cohesion and flow.

Synthesis in Literature Reviews

While any types of scholarly writing can include synthesis, it is most often discussed in the context of literature reviews. Visit our literature review pages for more information about synthesis in literature reviews.

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Get Organized

• Lit Review Prep Use this template to help you evaluate your sources, create article summaries for an annotated bibliography, and a synthesis matrix for your lit review outline.

Synthesize your Information

Synthesize: combine separate elements to form a whole.

Synthesis Matrix

A synthesis matrix helps you record the main points of each source and document how sources relate to each other.

After summarizing and evaluating your sources, arrange them in a matrix or use a citation manager to help you see how they relate to each other and apply to each of your themes or variables.  

By arranging your sources by theme or variable, you can see how your sources relate to each other, and can start thinking about how you weave them together to create a narrative.

• Step-by-Step Approach
• Example Matrix from NSCU
• Matrix Template
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• Last Updated: Sep 26, 2023 10:25 AM
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Synthesizing Sources

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When you look for areas where your sources agree or disagree and try to draw broader conclusions about your topic based on what your sources say, you are engaging in synthesis. Writing a research paper usually requires synthesizing the available sources in order to provide new insight or a different perspective into your particular topic (as opposed to simply restating what each individual source says about your research topic).

Note that synthesizing is not the same as summarizing.  

• A summary restates the information in one or more sources without providing new insight or reaching new conclusions.
• A synthesis draws on multiple sources to reach a broader conclusion.

There are two types of syntheses: explanatory syntheses and argumentative syntheses . Explanatory syntheses seek to bring sources together to explain a perspective and the reasoning behind it. Argumentative syntheses seek to bring sources together to make an argument. Both types of synthesis involve looking for relationships between sources and drawing conclusions.

In order to successfully synthesize your sources, you might begin by grouping your sources by topic and looking for connections. For example, if you were researching the pros and cons of encouraging healthy eating in children, you would want to separate your sources to find which ones agree with each other and which ones disagree.

After you have a good idea of what your sources are saying, you want to construct your body paragraphs in a way that acknowledges different sources and highlights where you can draw new conclusions.

As you continue synthesizing, here are a few points to remember:

• Don’t force a relationship between sources if there isn’t one. Not all of your sources have to complement one another.
• Do your best to highlight the relationships between sources in very clear ways.
• Don’t ignore any outliers in your research. It’s important to take note of every perspective (even those that disagree with your broader conclusions).

Example Syntheses

Below are two examples of synthesis: one where synthesis is NOT utilized well, and one where it is.

Parents are always trying to find ways to encourage healthy eating in their children. Elena Pearl Ben-Joseph, a doctor and writer for KidsHealth , encourages parents to be role models for their children by not dieting or vocalizing concerns about their body image. The first popular diet began in 1863. William Banting named it the “Banting” diet after himself, and it consisted of eating fruits, vegetables, meat, and dry wine. Despite the fact that dieting has been around for over a hundred and fifty years, parents should not diet because it hinders children’s understanding of healthy eating.

In this sample paragraph, the paragraph begins with one idea then drastically shifts to another. Rather than comparing the sources, the author simply describes their content. This leads the paragraph to veer in an different direction at the end, and it prevents the paragraph from expressing any strong arguments or conclusions.

An example of a stronger synthesis can be found below.

Parents are always trying to find ways to encourage healthy eating in their children. Different scientists and educators have different strategies for promoting a well-rounded diet while still encouraging body positivity in children. David R. Just and Joseph Price suggest in their article “Using Incentives to Encourage Healthy Eating in Children” that children are more likely to eat fruits and vegetables if they are given a reward (855-856). Similarly, Elena Pearl Ben-Joseph, a doctor and writer for Kids Health , encourages parents to be role models for their children. She states that “parents who are always dieting or complaining about their bodies may foster these same negative feelings in their kids. Try to keep a positive approach about food” (Ben-Joseph). Martha J. Nepper and Weiwen Chai support Ben-Joseph’s suggestions in their article “Parents’ Barriers and Strategies to Promote Healthy Eating among School-age Children.” Nepper and Chai note, “Parents felt that patience, consistency, educating themselves on proper nutrition, and having more healthy foods available in the home were important strategies when developing healthy eating habits for their children.” By following some of these ideas, parents can help their children develop healthy eating habits while still maintaining body positivity.

In this example, the author puts different sources in conversation with one another. Rather than simply describing the content of the sources in order, the author uses transitions (like "similarly") and makes the relationship between the sources evident.

Table of Contents

Ai, ethics & human agency, collaboration, information literacy, writing process, synthesizing your research findings.

• CC BY-NC-ND 4.0 by Christine Photinos - National University, San Diego

Synthesis is something you already do in your everyday life.  For example, if you are shopping for a new car, the research question you are trying to answer is, “Which car should I buy”?  You explore available models, prices, options, and consumer reviews, and you make comparisons.  For example:  Car X costs more than car Y but gets better mileage.  Or:  Reviewers A, B, and C all prefer Car X, but their praise is based primarily on design features that aren’t important to you.  It is this analysis across sources that moves you towards an answer to your question.

Early in an academic research project you are likely to find yourself making initial comparisons—for example, you may notice that Source A arrives at a conclusion very different from that of Source B—but the task of synthesis will become central to your work when you begin drafting your research paper or presentation. 

Remember, when you synthesize, you are not just compiling information.  You are organizing that information around a specific argument or question, and this work—your own intellectual work—is central to research writing.

Below are some questions that highlight ways in which the act of synthesizing brings together ideas and generates new knowledge. 

How do the sources speak to your specific argument or research question?

Your argument or research question is the main unifying element in your project.  Keep this in the forefront of your mind when you write about your sources.  Explain how, specifically, each source supports your central claim/s or suggests possible answers to your question.  For example:  Does the source provide essential background information or a definitional foundation for your argument or inquiry? Does it present numerical data that supports one of your points or helps you answer a question you have posed?  Does it present a theory that might be applied to some aspect of your project?  Does it present a recognized expert’s insights on your topic? 

How do the sources speak to each other? 

Sometimes you will find explicit dialogue between sources (for example, Source A refutes Source B by name), and sometimes you will need to bring your sources into dialogue (for example, Source A does not mention Source B, but you observe that the two are advancing similar or dissimilar arguments).  Attending to interrelationships among sources is at the heart of the task of synthesis.

Begin by asking:  What are the points of agreement?  Where are there disagreements?

But be aware that you are unlikely to find your sources in pure positions of “for” vs. “against.”  You are more likely to find agreement in some areas and disagreement in other areas.  You may also find agreement but for different reasons—such as different underlying values and priorities, or different methods of inquiry.

(See also Identifying a Conversation )

Where are there, or aren’t there, information gaps?

Where is the available information unreliable (for example, it might be difficult to trace back to primary sources), or limited, (for example, based on just a few case studies, or on just one geographical area), or difficult for non-specialists to access (for example, written in specialist language, or tucked away in a physical archive)? 

Does your inquiry contain sub-questions that may not at present be answerable, or that may not be answerable without additional primary research—for example, laboratory studies, direct observation, interviews with witnesses or participants, etc.?

Or, alternatively, is there a great deal of reliable, accessible information that addresses your question or speaks to your argument or inquiry? 

In considering these questions, you are engaged in synthesis: you are conducting an overview assessment of the field of available information and in this way generating composite knowledge.

Remember, synthesis is about pulling together information from a range of sources in order to answer a question or construct an argument. It is something you will be called upon to do in a wide variety of academic, professional, and personal contexts. Being able to dive into an ocean of information and surface with meaningful conclusions is an essential life skill.

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A Guide to Evidence Synthesis: What is Evidence Synthesis?

• Meet Our Team
• Our Published Reviews and Protocols
• What is Evidence Synthesis?
• Types of Evidence Synthesis
• Evidence Synthesis Across Disciplines
• Finding and Appraising Existing Systematic Reviews
• 0. Develop a Protocol
• 1. Draft your Research Question
• 2. Select Databases
• 3. Select Grey Literature Sources
• 4. Write a Search Strategy
• 5. Register a Protocol
• 6. Translate Search Strategies
• 7. Citation Management
• 8. Article Screening
• 9. Risk of Bias Assessment
• 10. Data Extraction
• 11. Synthesize, Map, or Describe the Results
• Evidence Synthesis Institute for Librarians
• Open Access Evidence Synthesis Resources

What are Evidence Syntheses?

What are evidence syntheses.

According to the Royal Society, 'evidence synthesis' refers to the process of bringing together information from a range of sources and disciplines to inform debates and decisions on specific issues. They generally include a methodical and comprehensive literature synthesis focused on a well-formulated research question.  Their aim is to identify and synthesize all  of the scholarly research on a particular topic, including both published and unpublished studies. Evidence syntheses are conducted in an unbiased, reproducible way to provide evidence for practice and policy-making, as well as to identify gaps in the research. Evidence syntheses may also include a meta-analysis, a more quantitative process of synthesizing and visualizing data retrieved from various studies. 

Evidence syntheses are much more time-intensive than traditional literature reviews and require a multi-person research team. See this PredicTER tool to get a sense of a systematic review timeline (one type of evidence synthesis). Before embarking on an evidence synthesis, it's important to clearly identify your reasons for conducting one. For a list of types of evidence synthesis projects, see the next tab.

How Does a Traditional Literature Review Differ From an Evidence Synthesis?

How does a systematic review differ from a traditional literature review.

One commonly used form of evidence synthesis is a systematic review.  This table compares a traditional literature review with a systematic review.

Video: Reproducibility and transparent methods (Video 3:25)

Reporting Standards

There are some reporting standards for evidence syntheses. These can serve as guidelines for protocol and manuscript preparation and journals may require that these standards are followed for the review type that is being employed (e.g. systematic review, scoping review, etc). ​

• PRISMA checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) is an evidence-based minimum set of items for reporting in systematic reviews and meta-analyses.
• PRISMA-P Standards An updated version of the original PRISMA standards for protocol development.
• PRISMA - ScR Reporting guidelines for scoping reviews and evidence maps
• PRISMA-IPD Standards Extension of the original PRISMA standards for systematic reviews and meta-analyses of individual participant data.
• EQUATOR Network The EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network is an international initiative that seeks to improve the reliability and value of published health research literature by promoting transparent and accurate reporting and wider use of robust reporting guidelines. They provide a list of various standards for reporting in systematic reviews.

Video: Guidelines and reporting standards

PRISMA Flow Diagram

The  PRISMA  flow diagram depicts the flow of information through the different phases of an evidence synthesis. It maps the search (number of records identified), screening (number of records included and excluded), and selection (reasons for exclusion).  Many evidence syntheses include a PRISMA flow diagram in the published manuscript.

See below for resources to help you generate your own PRISMA flow diagram.

• PRISMA Flow Diagram Tool
• PRISMA Flow Diagram Word Template
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• Next: Types of Evidence Synthesis >>
• Last Updated: Apr 24, 2024 2:56 PM
• URL: https://guides.library.cornell.edu/evidence-synthesis

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How to Write a Synthesis Essay

Last Updated: April 7, 2024 Fact Checked

This article was co-authored by Christopher Taylor, PhD . Christopher Taylor is an Adjunct Assistant Professor of English at Austin Community College in Texas. He received his PhD in English Literature and Medieval Studies from the University of Texas at Austin in 2014. There are 11 references cited in this article, which can be found at the bottom of the page. This article has been fact-checked, ensuring the accuracy of any cited facts and confirming the authority of its sources. This article has been viewed 1,121,355 times.

Writing a synthesis essay requires the ability to digest information and present it in an organized fashion. While this skill is developed in high school and college classes, it translates to the business and advertising world as well. Scroll down to Step 1 to begin learning how to write a synthesis essay.

Examining Your Topic

• Argument synthesis: This type of essay has a strong thesis statement that presents the writer's point of view. It organizes relevant information gathered from research in a logical manner to support the thesis' point of view. Business white papers known as position papers often take this form. This is the type of synthesis essay that students will write during the AP test.
• Review: Often written as a preliminary essay to an argument synthesis, a review essay is a discussion of what has been written previously on a topic, with a critical analysis of the sources covered. Its unstated thesis is usually that more research needs to be done in that area or that the topic problem has not been adequately addressed. This type of paper is common in social science classes and in medicine.
• Explanatory/background synthesis: This type of essay helps readers understand a topic by categorizing facts and presenting them to further the reader's understanding. It does not advocate a particular point of view, and if it has a thesis statement, the thesis is a weak one. Some business white papers take this form, although they are more likely to have a point of view, if understated.

• Example of a broad topic narrowed down into a reasonable synthesis essay topic: Instead of the broad topic of Social Media, you could discuss your view on the effects texting has had on the English language.
• If you've been assigned a topic as part of a class, make sure you read the prompt carefully and fully understand it.

• Keep in mind that it's better to do three sources well than to do five sources incompletely.
• Annotate each source by writing notes in the margins. This allows you to keep track of your train of thought, developing ideas, etc.

• Example: Texting has had a positive impact on the English language as it has helped the millennial generation create their own form of the language.

• If you wish to take on a claim by an opponent of your idea, and to poke holes in it, you should also find some ideas or quotes that go against your thesis statement, and plan ways to disprove them. This is called a concession, refutation, or rebuttal, which can strengthen your argument if you do it well.
• Example : For the thesis statement listed above, excellent sources would include quotes from linguists discussing the new words that have developed through 'text-speak', statistics that show the English language has evolved with almost every generation, and facts that show students still have the ability to write with the use of grammar and spelling (which your opponents would bring up as the main reason texting has had a negative effect on the English language).

Outlining Your Essay

• The introductory paragraph: 1. An introductory sentence that acts as a hook, capturing the reader's interest. 2. Identification of the issue you will be discussing. 3. Your thesis statement.
• The body paragraphs: 1. Topic sentence that gives one reason to support your thesis. 2. Your explanation and opinion of the topic sentence. 3. Support from your sources that backs up the claim you just made. 4. Explanation of the significance of the source(s).
• The conclusion paragraph: 1. State further significance of your topic from the evidence and reasons you discussed in the essay. 2. A profound thought or thoughtful ending for your paper.

• Example/illustration. This may be a detailed recount, summary, or direct quote from your source material that provides major support for your point of view. You may use more than one example or illustration, if your paper calls for it. You should not, however, make your paper a series of examples at the expense of supporting your thesis.
• Straw man. With this technique, you present an argument opposed to the argument stated in your thesis, then show the weaknesses and flaws of the counter-argument. This format shows your awareness of the opposition and your readiness to answer it. You present the counter-argument right after your thesis, followed by the evidence to refute it, and end with a positive argument that supports your thesis. [5] X Research source
• Concession. Essays with concessions are structured similar to those using the straw man technique, but they acknowledge the validity of the counter-argument while showing that the original argument is stronger. This structure is good for presenting papers to readers who hold the opposing viewpoint.
• Comparison and contrast. This structure compares similarities and contrasts differences between two subjects or sources to show the facets of both. Writing an essay with this structure requires a careful reading of your source material to find both subtle and major points of similarity and difference. This kind of essay can present its arguments source-by-source or by points of similarity or difference.

• Summary. This structure presents summaries of each of your relevant sources, making a progressively stronger argument for your thesis. It provides specific evidence to support your point of view, but usually omits presenting your own opinions. It's most commonly used for background and review essays.
• List of reasons. This is a series of sub-points that flow from the main point of your paper as stated in its thesis. Each reason is supported with evidence. As with the summary method, reasons should become progressively more important, with the most important reason last.

Writing Your Essay

• Your essay should have an introductory paragraph that includes your thesis , a body to present evidence that supports your thesis, and a conclusion that summarizes your point of view.

• Lengthy quotes of three lines or more should generally be set off as block quotes to better call attention to them. [7] X Trustworthy Source Purdue Online Writing Lab Trusted resource for writing and citation guidelines Go to source

Finalizing Your Essay

• Ask someone else to proofread your paper. The saying “two heads are better than one” still holds true. Ask a friend or colleague what would they add or remove from the paper. Most importantly, does your argument make sense, and is it clearly supported by your sources?

• Read the paper aloud to guarantee that you don't accidentally add in or take out words when reading in your head.
• If you can, get a friend or classmate to proofread your essay as well.

• Example of citing in an AP synthesis essay: McPherson claims “texting has changed the English language in a positive way--it has given a new generation their own unique way to communicate” (Source E).
• For college essays, you'll most likely use MLA format. Whichever format you use, be consistent in its use. You may also be asked to use APA or Chicago style.

• Example title: : English and the iPhone: Exploring the Benefits of 'Text-Speak'

Outline Template

Community Q&A

• Just as your title should fit your essay instead of writing your essay to fit the title, your thesis, once chosen, should direct your subsequent research instead of subsequent research altering your thesis � unless you find you've adopted an unsupportable thesis. Thanks Helpful 21 Not Helpful 8

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• ↑ https://success.uark.edu/get-help/student-resources/synthesis-paper.php
• ↑ https://www.unr.edu/writing-speaking-center/student-resources/writing-speaking-resources/mapping-a-synthesis-essay
• ↑ https://www.bgsu.edu/content/dam/BGSU/learning-commons/documents/writing/synthesis/planning-synthesis-essay.pdf
• ↑ https://writingcenterofprinceton.com/synthesis-essays-a-step-by-step-how-to-guide/
• ↑ https://owl.excelsior.edu/argument-and-critical-thinking/logical-fallacies/logical-fallacies-straw-man/
• ↑ https://writingcommons.org/section/rhetoric/rhetorical-stance/point-of-view/third-person-point-of-view/
• ↑ https://owl.purdue.edu/owl/research_and_citation/mla_style/mla_formatting_and_style_guide/mla_formatting_quotations.html
• ↑ https://owl.purdue.edu/owl/general_writing/the_writing_process/proofreading/steps_for_revising.html
• ↑ https://owl.purdue.edu/owl/general_writing/the_writing_process/proofreading/proofreading_suggestions.html
• ↑ https://www.edhs.org/ourpages/auto/2010/5/17/41759867/Synthesis%20Essay%20Introduction.pdf
• ↑ https://writing.umn.edu/sws/assets/pdf/quicktips/titles.pdf

About This Article

To write a synthesis essay, start by coming up with a thesis statement that you can support using all of the sources you've read for your essay. For example, your thesis statement could be "Texting has had a positive impact on the English language." Once you've got your thesis, go through your sources to find specific quotes, facts, and statistics that back up your claim. Structure your essay so it has an introduction that includes your thesis statement, a body that includes your arguments and evidence, and a conclusion that wraps everything up. For more tips on structuring your synthesis essay, read on! Did this summary help you? Yes No

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Synthesis in Research: Home

What is synthesis?

Synthesizing information is the opposite of analyzing information. When you read an article or book, you have to pull out specific concepts from the larger document in order to understand it. This is analyzing.

When you synthesize information, you take specific concepts and consider them together to understand how they compare/contrast and how they relate to one another. Synthesis involves combining multiple elements to create a whole.

In regard to course assignments, the  elements  refer to the outside sources you've gathered to support the ideas you want to present. The  whole  then becomes your conclusion(s) about those sources.

How do I synthesize information?

Note: These steps offer a guideline, but do what works for you best.

• This is where you really decide if you want to read specific materials
• If you have gathered a substantial amount of literature and reading all of it would prove overwhelming, read the abstracts to get a better idea of the content, then select the materials that would best support your assignment
• Describe and analyze the findings and/or the author's main ideas
• What's the author's message?
• What evidence do they use to support their message?
• What does the author want a reader to understand?
• What is the larger impact of the author's message?
• Compare and contrast the main ideas and other pertinent information you found in each source
• Evaluate the quality and significance of these main ideas
• Interpret the main ideas in the context of your research question or assignment topic
• This is the step where your synthesis of the information will lead to logical conclusions about that information
• These conclusions should speak directly to your research question (i.e. your question should have an answer)

I would like to give credit to Aultman Health Sciences Library.  Most of the information used to create this guide is from their English Research libguide .

• Last Updated: Apr 8, 2024 2:29 PM
• URL: https://library.defiance.edu/synthesis

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   419-783-2481      ,    library@ defiance.edu       ,   click the purple "ask us" side tab above.

• How it works

How to Synthesise Sources – Steps and Examples

Published by Olive Robin at October 17th, 2023 , Revised On October 17, 2023

The ability to effectively incorporate multiple sources into one’s work is not just a skill, but a necessity. Whether we are talking about research papers, articles, or even simple blog posts, synthesising sources can elevate our content to a more nuanced, comprehensive, and insightful level. But what does it truly mean to synthesise sources, and how does it differ from the commonly understood techniques of summarising and paraphrasing?

Importance of Synthesising Sources in Research and Writing

When finding sources , it is imperative to distinguish between various available information types. Secondary sources , for example, provide interpretations and analyses based on primary sources. Synthesising goes beyond the mere gathering of information. It involves the complex task of interweaving multiple sources to generate a broader and richer perspective. When we synthesise, we are not just collecting; we are connecting. 

By merging various viewpoints and data, we provide our readers with a well-rounded understanding of the topic. This approach ensures that our work is grounded in credible sources  while also adding unique insights.

Summarising, Paraphrasing, and Synthesising

At first glance, these three techniques might seem similar, but they serve distinctly different purposes:

Summarising

Synthesis is the art of blending multiple sources to create a unified narrative or argument. It is essential to use signal phrases to introduce these sources naturally, helping the reader follow the information flow. Block quotes can also be used for direct quotations, especially if they’re longer.

Paraphrasing

Here, we restate the original content using different words. While the wording changes, the essence and core meaning remain intact. This method is useful for clarifying complex ideas or for tailoring content to a specific audience.

Synthesising

Synthesis is the art of blending multiple sources to create a unified narrative or argument. It is not about echoing what others have said; it is about drawing connections, identifying patterns, and building a cohesive piece that holds its own merit.

What is Synthesising Sources?

Synthesising sources is a method used in research and writing wherein the author combines, interprets, and analyses information from various sources to generate a unified perspective, narrative, or argument. It involves a process that we can call source evaluation . It is an intricate process that goes beyond simply collecting data or quoting authors. Instead, it involves evaluating, integrating, and constructing a new narrative based on a collective understanding of all the sources under consideration.

Imagine a quilt where each piece of fabric represents a different source. Synthesising would be the act of sewing these individual pieces together in such a way that they form a beautiful, cohesive blanket. Each piece retains its uniqueness but contributes to the larger design and purpose of the quilt.

Objective of Synthesising

• Synthesising allows writers to delve deeper into topics by using a multitude of perspectives. This offers a more robust and comprehensive view than any single source could provide.
• By integrating diverse sources, authors can identify trends, consistencies, or discrepancies within a field or topic. This can lead to new insights or highlight areas needing further exploration.
• By interlinking sources, writers can add layers of complexity to their arguments, making their content more engaging and thought-provoking.
• While the sources themselves might not be new, the way in which they are combined and interpreted can lead to fresh conclusions and unique standpoints.
• Relying on a single source or a few like-minded ones can inadvertently introduce biases. Synthesising encourages the consideration of diverse viewpoints, ensuring a more balanced representation of the topic.

Why is Synthesis Important?

The art of synthesis, while a nuanced aspect of research and writing, holds unparalleled significance in constructing meaningful, in-depth content. Here is a detailed exploration of why synthesis is pivotal:

Enhancing Comprehension and Knowledge Depth

• Depth Over Breadth: While a vast amount of information exists on nearly any topic, true understanding isn’t about skimming the surface. Synthesising allows you to dive deeper, connecting various pieces of information and seeing the bigger picture.
• Clarifying Complexity: Topics, especially those in research, can be multifaceted. By merging multiple sources, we can simplify and explain intricate subjects more effectively.
• Reinforcing Concepts: By revisiting a concept from various sources and angles, the repetition, in a way, strengthens our grasp on the subject. It’s like studying from multiple textbooks; the overlap in content solidifies understanding.

Avoiding Plagiarism

• Original Thought Generation: While synthesising, you are compelled to merge ideas, compare viewpoints, and draw unique conclusions. This process naturally leads to producing original content rather than merely reproducing what one source says.
• Skilful Integration: A well-synthesised piece does not heavily rely on long, verbatim quotes. Instead, it seamlessly integrates information from various sources, duly cited, minimising the chances of unintentional plagiarism.
• Reflecting Authentic Engagement: When you synthesise, it showcases your genuine engagement with the material. It’s evident that you have not just copied content but have wrestled with the information, pondered upon it, and made it your own.

Developing a Holistic Perspective on a Topic

• Seeing the Full Spectrum: Single sources can offer a limited or biased viewpoint. Synthesis, by its nature, compels you to consult multiple sources, allowing for a more balanced and comprehensive view.
• Connecting the Dots: Life, society, and most academic subjects are interconnected. Synthesis helps recognise patterns, draw parallels, and understand how various elements interplay in the grand scheme of things.
• Elevating Critical Thinking: The act of synthesis hones your critical thinking skills. You’re constantly evaluating the validity of sources, comparing arguments, and discerning the weight of different perspectives. This makes your current work stronger and sharpens your intellect for future projects.

Steps of Synthesizing a Source

Here is a step-by-step guide on how to synthesise sources. 

Step 1: Read and Understand

Before you can synthesise sources effectively, you must first understand them individually. A strong synthesis is built upon a clear understanding of each source’s content, context, and nuances.

Tips To Ensure Comprehension

• Annotations: Make notes in the margins as you read, highlighting key points and ideas.
• Summarisation: After reading a section or an article, write a brief summary in your own words.
• Discussion: Talk about the content with peers or mentors. This can help clarify any confusion and deepen your understanding.
• Questioning: Constantly ask questions as you read. If something is unclear, revisit the content or consult supplementary materials.

Step 2: Identify Common Themes

Sources will often touch upon similar themes, even if they approach them differently. Recognising these themes can act as a foundation for synthesis.

• Mind Mapping: Visualise the interconnectedness of topics and subtopics.
• Lists: Create lists of similar ideas or arguments from different sources.
• Highlighting: Use colour codes to highlight recurring themes across different documents.

Step 3: Analyse and Compare

Different sources might have diverging opinions or findings. Recognising these differences is crucial to produce a balanced synthesis.

• Side-by-Side Analysis: Put the information from various sources next to each other to see how they align or diverge.
• Critical Evaluation: Ask yourself why sources might have different perspectives. Consider the methodology, context, or biases that could contribute.

Determining the Relevance of Each Source

Not all sources will hold equal weight or relevance in your synthesis.

• Criteria Checklist: Establish criteria for relevance (e.g., publication date, author credentials) and evaluate each source against this.
• Priority Setting: Decide which sources offer primary insights and which offer supplementary information.

Step 4: Organise Information

A clear structure is essential to guide your readers through the synthesised narrative.

• Outlines: Create a traditional outline that sequences your main points and supports them with subpoints from your sources.
• Flowcharts: For more complex topics, flowcharts can visually demonstrate the progression of ideas and their interconnections.

Step 5: Craft Your Narrative

This step involves the actual writing, where you combine the insights, evidence, and analysis into a singular narrative.

• Transitional Phrasing: Use transitions to move between ideas and sources smoothly.
• Voice Consistency: Even though you integrate multiple sources, ensure that the narrative maintains a consistent voice and tone.

Step 6: Cite Appropriately

Always credit original authors and sources to maintain integrity in your work and avoid plagiarism. Knowing how to cite sources is crucial in this process.

• In-text Citations: Whenever you refer to, paraphrase, or quote a source, provide a citation.

Different Citation Styles and Choosing The Right One

There are multiple citation styles (e.g., APA, MLA, Chicago), and your choice will often depend on your discipline or the preference of your institution or publication.

• Guideline Review: Familiarise yourself with the preferred citation style’s guidelines.

Citation Tools: Consider using tools like Zotero, Mendeley, or EndNote to help streamline and manage your citations.

The research done by our experts have:

• Precision and Clarity
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Examples of Source Synthesis

Let’s explore some examples of synthesising sources. 

Example 1: Synthesising sources on climate change

Scenario: You have sources that discuss the causes of climate change. Some sources argue for anthropogenic (human-caused) factors, while others emphasise natural cycles.

Synthesis Approach

• Begin with an overview of climate change, its impacts, and its significance.
• Introduce the anthropogenic viewpoint, citing research on the rise of CO2 from industrial processes, deforestation, etc.
• Present the natural cycle perspective, highlighting periods in Earth’s history where temperature fluctuations were observed.
• Discuss overlaps, such as how human activities might exacerbate natural cycles.
• Conclude by emphasising the consensus in the scientific community about human contributions to recent climate change, but acknowledge the existence of natural cycles as part of Earth’s climate history.

Example 2: Merging Historical Texts on a Particular Event

Scenario: You are examining the Battle of Waterloo from British, French, and Prussian primary sources.

• Provide background on the Battle of Waterloo, setting the stage.
• Introduce the British perspective, detailing their strategies, key figures, and their account of the battle’s progression.
• Shift to the French viewpoint, noting their strategic decisions, challenges, and Napoleon’s role.
• Explore the Prussian account, emphasising their contributions and coordination with the British.
• Highlight areas of agreement among the sources (e.g., timeline of events) and areas of discrepancy or unique insights (e.g., differing reasons for the outcome).
• Conclude with a comprehensive view of the battle, incorporating insights from all perspectives and its significance in European history.

Example 3: Synthesising Qualitative And Quantitative Research On A Social Issue

Scenario: You are researching the effects of remote learning on student performance and well-being during the pandemic.

• Start with an introduction to the sudden shift to remote learning due to COVID-19.
• Present quantitative data: statistics showcasing the drop or rise in student grades, attendance rates, and standardised test scores.
• Introduce qualitative insights, like interviews or case studies, highlighting student sentiments, challenges faced at home, or feelings of isolation.
• Discuss the interplay between numbers and narratives. For instance, a drop in grades (quantitative) could be related to a lack of motivation or home distractions (qualitative).
• Compare outcomes across different demographics, using both types of data to show how remote learning might affect diverse student populations differently.
• Conclude with a holistic understanding of the impacts of remote learning, noting areas that need further research or intervention.

Common Mistakes to Avoid when Synthesising Sources

• Relying heavily on a single source limits the depth and breadth of your understanding. It may also inadvertently introduce bias if that source isn’t comprehensive or neutral.
• How to Avoid: Ensure you consult various sources for a well-rounded view. This includes both primary and secondary sources, academic articles, and more accessible pieces like news articles or blogs, if relevant.
• Every source comes with its own perspective. Identifying these biases can lead to a skewed understanding of your topic.
• How to Avoid: Critical reading is key. Always consider who the author is, their potential motivations, the context in which they’re writing, and the methodologies they use.
• Simply presenting what each source says without drawing connections or highlighting contrasts misses the essence of synthesis.
• How to Avoid: As you research, actively look for common themes, conflicting viewpoints, and unique insights. Your goal is to weave a narrative that reflects a comprehensive understanding of all these elements.

Tools and Resources for Synthesising Sources

These are the different tools that can be used for synthesising sources. 

Citation Tools

Managing references can be cumbersome, especially when dealing with numerous sources. Citation tools can help organise, format, and insert citations with ease.

• Zotero: A free, open-source tool that helps you collect, organise, cite, and share research.
• Mendeley: A reference manager and academic social network that can help you organise your research, collaborate with others online, and discover the latest developments.

Mind-Mapping Software or Apps

Mind mapping helps visually organise and interlink ideas, making the synthesis process more intuitive.

• MindMeister: An online mind-mapping tool that lets you capture, develop, and share ideas visually.
• XMind: A popular mind mapping and brainstorming software with various templates to help structure your thoughts.

Note-Taking Apps and Strategies

Effective note-taking is fundamental to understanding and organising information from various sources. Digital note-taking apps often offer features like tagging, search functionalities, and integration with other tools.

• Evernote: A cross-platform app designed for note-taking, organising, and archiving.
• Microsoft OneNote: A digital notebook that allows you to gather drawings, handwritten or typed notes, and save web clippings.
• Cornell Note-taking System: A structured method of note-taking that divides the paper into sections, encouraging active engagement with the material.

Frequently Asked Questions

What is a literature review.

A literature review is a comprehensive survey of existing research on a particular topic, synthesising findings to provide an overview of key concepts, debates, and gaps in knowledge. It establishes a foundation for new research, highlighting relevant studies and contextualising them within the broader academic conversation.

How to synthesise a source?

To synthesise a source, thoroughly understand its content, and then integrate its insights with information from other sources. This involves comparing and contrasting viewpoints, identifying patterns, and constructing a cohesive narrative or argument that offers a broader perspective rather than merely echoing the original source’s content.

Why do I need to cite sources?

Citing sources acknowledges original authors, maintains academic integrity, and provides readers with a reference for verification. It prevents plagiarism by giving credit to the ideas and research of others, allowing readers to trace the evolution of thought and confirm the reliability and accuracy of the presented information.

What are topic sentences?

Topic sentences are the main statements that introduce and summarise a paragraph’s main idea or focus. They provide context and direction, helping readers follow the writer’s argument or narrative. Typically placed at the beginning of a paragraph, they act as signposts, guiding the flow of the discussion.

You May Also Like

In any form of written communication, be it academic writing, journalism, or even casual blogging, there comes a time when we need to reference another’s words to support, explain, or emphasise our points.

In today’s information age, where vast amounts of knowledge are easily accessible, it is crucial to know how to use and represent that knowledge correctly and how to cite sources properly.

Academic sources, also known as scholarly sources or academic references, are materials used by researchers, scholars, and students to support their academic work. These sources are specifically created for use in academic contexts and contribute to the body of knowledge in a particular field of study.

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Should I do a synthesis (i.e. literature review)?

• Questions & Quandaries
• Published: 18 April 2024

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• H. Carrie Chen 1 ,
• Ayelet Kuper 2 , 3 , 4 ,
• Jennifer Cleland 5 &
• Patricia O’Sullivan 6  

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This column is intended to address the kinds of knotty problems and dilemmas with which many scholars grapple in studying health professions education. In this article, the authors address the question of whether one should conduct a literature review or knowledge synthesis, considering the why, when, and how, as well as its potential pitfalls. The goal is to guide supervisors and students who are considering whether to embark on a literature review in education research.

Avoid common mistakes on your manuscript.

Two junior colleagues come to you to ask your advice about carrying out a literature review on a particular topic. “Should they?” immediately pops into your mind, followed closely by, if yes, then what kind of literature review is appropriate? Our experience is that colleagues often come to suggest a literature review to “kick start” their research (in fact, some academic programs require them as part of degree requirements), without a full understanding of the work involved, the different types of literature review, and what type of literature review might be most suitable for their research question. In this Questions and Quandaries, we address the question of literature reviews in education research, considering the why, when, and how, as well as potential pitfalls.

First, what is meant by literature review? The term literature review has been used to refer to both a review of the literature and a knowledge synthesis (Maggio et al., 2018 ; Siddaway et al., 2019 ). For our purposes, we employ the term as commonly used to refer to a knowledge synthesis , which is a formal comprehensive review of the existing body of literature on a topic. It is a research approach that critically integrates and synthesizes available evidence from multiple studies to provide insight and allow the drawing of conclusions. It is an example of Boyer’s scholarship of integration (Boyer, 1990 ). In contrast, a review of the literature is a relatively casual and expedient method for attaining a general overview of the state of knowledge on a given topic to make the argument that a new study is needed. In this interpretation, a literature review serves as a key starting point for anyone conducting research by identifying gaps in the literature, informing the study question, and situating one’s study in the field.

Whether a formal knowledge synthesis should be done depends on if a review is needed and what the rationale is for the review. The first question to consider is whether a literature review already exists. If no, is there enough literature published on the topic to warrant a review? If yes, does the previous review need updating? How long has it been since the last review and has the literature expanded so much or are there important new studies that need integrating to justify an updated review? Or were there flaws in the previous review that one intends to address with a new review? Or does one intend to address a different question than the focus of the previous review?

If the knowledge synthesis is to be done, it should be driven by a research question. What is the research question? Can it be answered by a review? What is the purpose of the synthesis? There are two main purposes for knowledge synthesis– knowledge support and decision support. Knowledge support summarizes the evidence while decision support takes additional analytical steps to allow for decision-making in particular contexts (Mays et al., 2005 ).

If the purpose is to provide knowledge support, then the question is how or what will the knowledge synthesis add to the literature? Will it establish the state of knowledge in an area, identify gaps in the literature/knowledge base, and/or map opportunities for future research? Cornett et al., performed a scoping review of the literature on professional identity, focusing on how professional identity is described, why the studies where done, and what constructs of identity were used. Their findings advanced understanding of the state of knowledge by indicating that professional identity studies were driven primarily by the desire to examine the impact of political, social and healthcare reforms and advances, and that the various constructs of professional identity across the literature could be categorized into five themes (Cornett et al., 2023 ).

If, on the other hand, the purpose of the knowledge synthesis is to provide decision support, for whom will the synthesis be relevant and how will it improve practice? Will the synthesis result in tools such as guidelines or recommendations for practitioners and policymakers? An example of a knowledge synthesis for decision support is a systematic review conducted by Spencer and colleagues to examine the validity evidence for use of the Ottawa Surgical Competency Operating Room Evaluation (OSCORE) assessment tool. The authors summarized their findings with recommendations for educational practice– namely supporting the use of the OSCORE for in-the-moment entrustment decisions by frontline supervisors in surgical fields but cautioning about the limited evidence for support of its use in summative promotions decisions or non-surgical contexts (Spencer et al., 2022 ).

If a knowledge synthesis is indeed appropriate, its methodology should be informed by its research question and purpose. We do not have the space to discuss the various types of knowledge synthesis except to say that several types have been described in the literature. The five most common types in health professions education are narrative reviews, systematic reviews, umbrella reviews (meta-syntheses), scoping reviews, and realist reviews (Maggio et al., 2018 ). These represent different epistemologies, serve different review purposes, use different methods, and result in different review outcomes (Gordon, 2016 ).

Each type of review lends itself best to answering a certain type of research question. For instance, narrative reviews generally describe what is known about a topic without necessarily answering a specific empirical question (Maggio et al., 2018 ). A recent example of a narrative review focused on schoolwide wellbeing programs, describing what is known about the key characteristics and mediating factors that influence student support and identifying critical tensions around confidentiality that could make or break programs (Tan et al., 2023 ). Umbrella reviews, on the other hand, synthesize evidence from multiple reviews or meta-analyses and can illuminate agreement, inconsistencies, or evolution of evidence on a topic. For example, an umbrella review on problem-based learning highlighted the shift in research focus over time from does it work, to how does it work, to how does it work in different contexts, and pointed to directions for new research (Hung et al., 2019 ).

Practical questions for those considering a literature review include whether one has the time required and an appropriate team to conduct a high-quality knowledge synthesis. Regardless of the type of knowledge synthesis and use of quantitative or qualitative methods, all require rigorous and clear methods that allow for reproducibility. This can take time, up to 12–18 months. A high-quality knowledge synthesis also requires a team whose members have expertise not only in the content matter, but also in knowledge synthesis methodology and in literature searches (i.e. a librarian). A team with multiple reviewers with a variety of perspectives can also help manage the volume of large reviews, minimize potential biases, and strengthen the critical analysis.

Finally, a pitfall one should be careful to avoid is merely summarizing everything in the literature without critical evaluation and integration of the information. A knowledge synthesis that merely bean counts or presents a collection of unconnected information that has not been reflected upon or critically analyzed does not truly advance knowledge or decision-making. Rather, it leads us back to our original question of whether it should have been done in the first place.

Boyer, E. L. (1990). Scholarship reconsidered: Priorities of the professoriate (pp. 18–21). Princeton University Press.

Cornett, M., Palermo, C., & Ash, S. (2023). Professional identity research in the health professions—a scoping review. Advances in Health Sciences Education , 28 (2), 589–642.

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Gordon, M. (2016). Are we talking the same paradigm? Considering methodological choices in health education systematic review. Medical Teacher , 38 (7), 746–750.

Hung, W., Dolmans, D. H. J. M., & van Merrienboer, J. J. G. (2019). A review to identify key perspectives in PBL meta-analyses and reviews: Trends, gaps and future research directions. Advances in Health Sciences Education , 24 , 943–957.

Maggio, L. A., Thomas, A., & Durning, S. J. (2018). Knowledge synthesis. In T. Swanwick, K. Forrest, & B. C. O’Brien (Eds.), Understanding Medical Education: Evidence, theory, and practice (pp. 457–469). Wiley.

Mays, N., Pope, C., & Popay, J. (2005). Systematically reviewing qualitative and quantitative evidence to inform management and policy-making in the health field. Journal of Health Services Research & Policy , 10 (1_suppl), 6–20.

Siddaway, A. P., Wood, A. M., & Hedges, L. V. (2019). How to do a systematic review: A best practice guide for conducting and reporting narrative reviews, meta-analyses, and meta-syntheses. Annual Review of Psychology , 70 , 747–770.

Spencer, M., Sherbino, J., & Hatala, R. (2022). Examining the validity argument for the Ottawa Surgical Competency operating room evaluation (OSCORE): A systematic review and narrative synthesis. Advances in Health Sciences Education , 27 , 659–689.

Tan, E., Frambach, J., Driessen, E., & Cleland, J. (2023). Opening the black box of school-wide student wellbeing programmes: A critical narrative review informed by activity theory. Advances in Health Sciences Education . https://doi.org/10.1007/s10459-023-10261-8 . Epub ahead of print 02 July 2023.

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H. Carrie Chen

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Chen, H.C., Kuper, A., Cleland, J. et al. Should I do a synthesis (i.e. literature review)?. Adv in Health Sci Educ (2024). https://doi.org/10.1007/s10459-024-10335-1

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A new method for enzymatic synthesis of potential RNA therapeutics

by Institute of Organic Chemistry and Biochemistry of the CAS

A team of researchers at IOCB Prague led by Prof. Michal Hocek has developed a novel method for preparing ribonucleic acid (RNA) containing modified bases. Innovative use of engineered DNA polymerases, enzymes commonly used for the synthesis of DNA, led to the development of a general method for the synthesis of RNA modified only at selected sites or even RNA containing various modifications at all nucleotide building blocks.

This opens the door to applications in chemical biology and, in a longer perspective, in the therapy of hitherto incurable diseases. The paper was published in the journal Nature Communications .

The researchers used two artificially modified DNA polymerases known to be capable of synthesizing RNA. In nature, DNA polymerases synthesize only DNA, while RNA polymerases produce RNA. Hocek's team has developed a procedure for preparing modified RNA with significant advantages over the commonly available method, in vitro transcription with viral T7 RNA polymerase, which, for example, is used in the production of well-known mRNA vaccines.

Modified DNA polymerases can incorporate virtually any modification into any RNA sequence, even only at selected specific sites, precisely where the given modification is required. The commonly used T7 RNA polymerase can only incorporate the modified base in all positions in the RNA but not in one precisely designated location. Therefore, if the RNA requires site-specific modification, the classical in vitro transcription fails and a different method is needed.

And that's exactly what the team at IOCB has developed, a method that in many respects is comparable to the commonly used in vitro transcription while eliminating most of its pitfalls and offering completely new possibilities. Now, various specific RNA probes can be prepared for the study of RNA biology, which is currently a very hot topic. In the longer term, however, there is great promise for therapeutic applications, especially for mRNA therapeutics.

The researchers chose two specific positions in mRNA for modifications and found that they led to a significant increase in the production of certain proteins. This is excellent news for the development of potential mRNA drugs. If mRNA modified in this way could be introduced into cells, it would be possible to trigger the production of a protein which the body lacks or which is defective.

"Our method may lead to the development of therapeutics for the treatment of many diseases, including cancer and some genetic diseases caused by a malfunctioning or missing protein. It allows for the replacement of a missing or poorly functioning protein," says Hocek. "RNA therapy is a powerful technology, and it may emerge as one of the main directions of drug development within the next ten years."

The challenge is how to ensure that there is just the right amount of protein —not scarce and neither excessive—at just the right time. In most cases, if there is too much of certain proteins, they are harmful to the body. That's why mRNA naturally breaks down quickly in the cell and the entire process is very finely regulated by the body.

According to Hocek, their method will not replace the classical in vitro transcription. However, if there is a need for specific modifications to occur only at selected RNA sites, then the advantage will lie with the novel method from IOCB Prague.

Journal information: Nature Communications

Provided by Institute of Organic Chemistry and Biochemistry of the CAS

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