review essay topics in biology

Review Essays for the Biological Sciences

A review essay for the biological sciences serves to discuss and synthesize key findings on a particular subject. Review papers are helpful to the writer and their colleagues in gaining critical awareness in specialized fields that may or may not be their own.

This guide explains what a review essay is and identifies several approaches to writing a review essay. Although much of the information is geared directly to the biological sciences, it is generally applicable to review essays in all fields.

What is a Review Essay?

A review essay is a synthesis of primary sources (mainly research papers presented in academic journals) on a given topic. A biological review essay demonstrates that the writer has thorough understanding of the literature and can formulate a useful analysis. While no new research is presented by the writer, the field benefits from the review by recieving a new perspective. There are several approaches one may take when writing a biological review:

A State of the art review

A state of the art review considers mainly the most current research in a given area. The review may offer new perspectives on an issue or point out an area in need of further research.

A Historical review

A historical review is a survey of the development of a particular field of study. It may examine the early stages of the field, key findings to present, key theoretical models and their evolution, etc.

A Comparison of perspectives review

A comparison of perspectives review contrasts various ways of looking at a certain topic. If in fact there is a debate over some process or idea, a comparison of perspectives review may illustrate the research that supports both sides. A comparison of perspectives review may introduce a new perspective by way of comparing it to another.

A Synthesis of two fields review

Many times researchers in different fields may be working on similar problems. A synthesis of two fields review provides insights into a given topic based on a review of the literature from two or more disciplines.

A Theoretical model building review

A theoretical model building review examines the literature within a given area with the intention of developing new theoretical assumptions.

Key considerations for writing a biological review essay

This guide will inform you of certain things not to miss when writing a review essay. It will also give you some information about using and documenting your sources.

Keep your focus narrow.

When writing a review essay it is important to keep the scope of the topic narrow enough so that you can discuss it thoroughly. For example a topic such as air quality in factories could be narrowed significantly to something like carbon dioxide levels in auto manufacturing plants .

A good way to narrow your focus is to start with a broad topic that is of some interest to you, then read some of the literature in the field. Look for a thread of the discussion that points to a more specific topic.

Analyze, synthesize, and interpret.

A review essay is not a pure summary of the information you read for your review. You are required to analyze, synthesize, and interpret the information you read in some meaningful way.

It is not enough to simply present the material you have found, you must go beyond that and explain its relevance and significance to the topic at hand.

Establish a clear thesis from the onset of your writing and examine which pieces of your reading help you in developing and supporting the ideas in your thesis.

Use only academic sources.

A review essay reviews the academic body of literature—articles and research presented in academic journals. Lay periodicals such as, Discover , Scientific America , or Popular Science , are not adequate sources for an academic review essay.

If you are having trouble finding the academic journals in your field, ask one of your professors or a reference librarian.

Document your sources.

The material that you discuss in a review essay is obviously not your own, therefore it is crucial to document your sources properly. Proper documentation is crucial for two reasons: 1. It prevents the writer from being accused of plagiarism and 2. It gives the reader the opportunity to locate the sources the writer has reviewed because they may find them valuable in their own academic pursuits. Proper documentation depends on which style guide you are following.

Quote sparingly and properly.

No one wants to read a paper that is simply a string of quotes; reserve direct quotations for when you want to create a big impact. Often times the way a quote is written will not fit with the language or the style of your paper so paraphrase the authors words carefully and verbage as necessary to create a well formed paragraph.

Choose an informative title.

The title you choose for your review essay should give some indication of what lies ahead for the reader. You might consider the process you took in narrowing your topic to help you with your title—think of the title as something specific rather than a vague representation of your paper's topic. For example the title Wastewater Treatment might be more informative if rewritten as The Removal of Cloroform Bacteria as Practiced by California's Municipal Water Treatment Facilities .

Consider your audience.

More than likely your audience will be your academic peers, therefore you can make a couple assumptions and choose a writing style that suits the audience. Though your audience may lack the detailed knowledge you have about your topic, they do have similar background knowledge to you. You can assume that you audience understands much of the technical language you have to use to write about your topic and you do not have to go into great detail about background information.

Elements of a review essay

This guide explains each section of a review essay and gives specific information about what should be included in each.

On the title page include the title, your name, and the date. Your instructor may have additional requirements (such as the course number, etc.) so be sure to follow the guidelines on the assignment sheet. Professional journals may also have more specific requirements for the title page.

An abstract is a brief summary of your review. The abstract should include only the main points of your review. Think of the abstract as a chance for the reader to preview your paper and decide if they want to read on for the details.

Introduction

The introduction of your review should accomplish three things:

• It may sound redundant to "introduce" your topic in the introduction, but often times writer's fail to do so. Let the reader in on background information specific to the topic, define terms that may be unfamiliar to them, explain the scope of the discussion, and your purpose for writing the review.
• Think of your review essay as a statement in the larger conversation of your academic community. Your review is your way of entering into that conversation and it is important to briefly address why your review is relevant to the discussion. You may feel the relevance is obvious because you are so familiar with the topic, but your readers have not yet established that familiarity.
• The thesis is the main idea that you want to get across to your reader. your thesis should be a clear statement of what you intend to prove or illustrate by your review. By revealing your thesis in the introduction the reader knows what to expect in the rest of the paper.

The discussion section is the body of your paper. The discussion section contains information that develops and supports your thesis. While there is no particular form that a discussion section must take there are several considerations that a writer must follow when building a discussion.

• A review essay is not simply a summary of literature you have reviewed. Be careful not to leave out your own analysis of the ideas presented in the literature. Synthesize the material from all the works—what are the connections you see, or the connections you are trying to illustrate, among your readings.

A review essay is not a pure summary of the information you read for your review. You are required to analyze, synthesize, and interpret the information you read in some meaningful way. It is not enough to simply present the material you have found, you must go beyond that and explain its relevance and significance to the topic at hand. Establish a clear thesis from the onset of your writing and examine which pieces of your reading help you in developing and supporting the ideas in your thesis.

• Keep your discussion focused on your topic and more importantly your thesis. Don't let tangents or extraneous material get in the way of a concise, coherent discussion. A well focused paper is crucial in getting your message across to your reader.
• Keeping your points organized makes it easier for the reader to follow along and make sense of your review. Start each paragraph with a topic sentence that relates back to your thesis. The headings used for this guide give you some idea of how to organize the overall paper, but as far as the discussion section goes use meaningful subheadings that relate to your content to organize your points.
• Your thesis should illustrate your objectives in writing the review and your discussion should serve to accomplish your objectives. Make sure your keep your discussion related to the thesis in order to meet your objectives. If you find that your discussion does not relate so much to your thesis, don't panic, you might want to revise your thesis instead of reworking the discussion.

Conclusions

Because the conclusions section often gets left for last it is often the weakest part of a student review essay. It is as crucial a part of the paper as any and should be treated as such.

A good conclusion should illustrate the key connections between your major points and your thesis as well as they key connections between your thesis and the broader discussion—what is the significance of your paper in a larger context? Make some conclusions —where have you arrived as a result of writing this paper?

Be careful not to present any new information in the conclusion section.

Here you report all the works you have cited in your paper. The format for a references page varies by discipline as does how you should cite your references within the paper.

Citation Information

Neal Bastek. (1994-2024). Review Essays for the Biological Sciences. The WAC Clearinghouse. Colorado State University. Available at https://wac.colostate.edu/repository/writing/guides/.

Copyright Information

Copyright © 1994-2024 Colorado State University and/or this site's authors, developers, and contributors . Some material displayed on this site is used with permission.

240 Interesting Biology Topics for Essays & Research Papers

Biology is often called the science of life . From bacteria to whales, biologists study all kinds of organisms. Have you ever wondered why bees dance? Or how can chickens be the closest modern relatives to dinosaurs? The buzzing world is full of complex wonders like these. That’s why it’s so easy to find a biology research topic of your liking.

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If you need to craft a biology essay, this article is for you. Here you can learn about research areas and fields in biology. Besides, you will find 220 interesting biology topics to write about. Read on to refresh your knowledge of microbiology, epidemiology, and more.

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🔝 Top 10 Biology Research Topics

📚 areas of research in biology, ⭐ top 10 interesting biology topics for essays, 🍎 biological topics for high school.

• 🦠 Microbiology Topics
• 💀 Anatomy & Human Biology
• 🔬 Cell & Molecular Biology
• ♻️ Environmental Biology
• 🐬 Marine Biology
• 🌻 Plant Biology
• 🧬 Evolutionary Biology
• 👶🧑 Developmental Biology
• 😷 Epidemiology & Population Topics in Biology
• 📜 History of Biology

🔍 References

• Are viruses alive?
• How do emotions work?
• What is the role of hormones?
• Ways to recover endangered species
• Are allergies a sign of immune disorder?
• What is the function of chromosomes?
• Robert Hooke’s contribution to biology
• The difference between Darwinism and evolution
• The process of bacterial invasion of the body
• Ways to strengthen the human immune system

Biologists operate on a vast scale. Naturally, there are plenty of research areas. Let’s sort them out:

• Microbiology. Microbiologists examine minute organisms. Many of them, such as viruses, can cause infectious diseases. Because of this, microbiology is strongly linked with immunology.
• Anatomy. Anatomical research focuses on the structure of tissues and organs.
• Cell and molecular biology. Cells are the basis for every living being. The key topic in this area is the molecular organization of cells.
• Environmental biology. Our environment needs support, and environmental biologists provide it. They study ecosystems to find out how humans affect nature. Scientists in this area also observe how organisms react to their surroundings.
• Marine biology. This branch is concerned with life in the deep seas. Oceanography is a crucial part of marine biology.

• Botany. This study is also called plant biology. It studies the properties of organisms that need sun and water to survive. Common categories of plants include trees, shrubs, and flowers.
• Evolutionary biology. All that lives is always evolving. Organisms create, merge, and delete genes. Evolutionary biologists monitor these changes.
• Developmental biology. Research in this area includes studying tissue regeneration and cell growth.
• Epidemiology. Epidemiologists investigate diseases and health conditions. Key questions include: Where does a disease originate from? How does it transmit? What risks are there?

With this overview in mind, you’re ready to choose an interesting biological topic.

• 4 types of biotechnology
• Main branches of biochemistry
• Pros and cons of gene therapy
• Exobiology vs. astrobiology
• Biological functions of the DNA
• Levels of biological organization
• Properties of the phylogenetic tree
• Classification of invertebrate animals
• History of modern light microscopes
• The early modern period of plant systematics

From peas to platypuses: high school biology covers a wide range of topics. In your biology essay, you’ll have the chance to familiarize yourself with any of them. Your options are almost endless! Consult our list of 20 popular ideas to get your research started:

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• Compare the types of cell reproduction. 
• How did Gregor Mendel discover heredity? 
• Cell structure: prokaryotes vs. eukaryotes . 
• Enzymes : what do we need them for? 
• Explain how photosynthesis converts CO2 into O2. 
• How does the human metabolism work? 
• What are the differences between mitosis and meiosis?  
• How do you predict the probability of inheriting a gene? 
• Describe the structure of DNA.  
• What is PCR used for? 
• Biotechnology: the mechanisms behind cloning . 
• Survival of the fittest: what does natural selection mean? 
• Discuss the latest evidence for Darwin’s theory of evolution. 
• The tree of life: how does this concept depict the relationships between species? 
• What kind of strategies do organisms use to get nutrition? 
• Dinosaurs and their modern relatives: what do we know about them? 
• How does our nervous system transport information? 
• Explain the mechanisms behind the carbon cycle. 
• Examine the human impact on biodiversity . 
• What factors regulate population dynamics ? 

🦠 Microbiology Research Topics for Students

The world of microbiology consists of tiny organisms. Researchers study microbes and other simple life forms such as bacteria and fungi. This way, they aim to solve environmental as well as medical issues.

• How do microbes develop resistance? 
• Give an overview of our immune system’s defense mechanisms. 
• Contrast the types of microbiomes . 
• What are the industrial applications for microbiology ? 
• How do you degrade soil pollutants using microbes? 
• Investigate examples of agents that kill bacteria. 
• What makes yeast versatile? 
• The differences between virions and viroids. 
• What are acellular agents? 
• Give an overview of the biochemical properties of fungi . 
• What are possible causes for asthma ? 
• The relationship between stress and our immune system’s performance. 
• How do vaccines work? 
• Examine the structure of archaeal genes. 
• Why is microbial diversity important? 

• How do microbes contribute to an ecosystem? 
• The role of microbes in food contamination. 
• How do bacteria turn milk into yogurt? 
• Applications of microbial biotechnology. 
• Describe the four groups of protozoa. 

💀 Anatomy & Human Biology Topics

Human biology studies people as single organisms and in the context of populations. Two of its essential parts are anatomy and anthropology. The latter studies the evolution of humankind. The former is more concerned with body structure. Combine all three subjects to gain a 360° view of humanity!

• Describe the functions of the respiratory system.  
• What happens to your body if you’re anemic ? 
• Outline the history of the human population. 
• How does medical anthropology help us understand health? 
• Reading bones: what types of information can osteologists gather? 
• Biomechanics: what makes humans move? 
• Compare the proposed effects of various current trends in nutrition . 
• Explore the psychological factors that influence one’s health. 
• How does your brain control your behavior? 
• Synapses: structure and mechanisms. 
• Explain how kidneys filter blood. 
• What regulates muscle contraction ? 
• Discuss the new reproductive technologies from an anthropological perspective. 
• Describe the structure of a skeletal muscle fiber. 
• The cerebral cortex: what does it do? 
• Brain, hormones, and emotions. 
• Functions of the sodium-potassium pump. 
• Examine what blood consists of. 
• What happens when your heart skips a beat? 
• Is the growth in the human population out of control? 

🔬 Cell & Molecular Biology Research Topics

Your body’s fundamental structure is made up of cells. Their properties are in the center of interest for cell biologists. They investigate a cell’s life cycle and its vital functions. On a molecular level, this includes the role of chemical processes in cell activity.

• How does cancer affect the body’s cell growth? 
• The protein paradox: what is the right amount of protein? 
• How do cells heal bones? 
• The ethics of stem cell research . 
• Investigate the communication methods between cells. 
• Explore the link between the environment and our DNA. 
• Current trends in molecular biochemistry. 
• Telomerase: will it ever be possible to reverse aging processes? 
• What do we know about axon guidance? 
• Where does our brain keep the memories? 
• Why do cells become sticky? 
• High-resolution microscopy: ways to advance molecular research. 
• How do cilia move cells? 

• Treating glaucoma : is surgery always necessary? 
• The role of microtubules in the nervous system. 
• Diffusion : means of transport within cells. 
• What does the central dogma of molecular biology state? 
• Trace the steps of DNA translation. 
• Why do cells need to eat their dead counterparts? 
• How does protein biosynthesis work? 

♻️ Environmental Biology Topics to Research

Environmental biologists ensure our harmonic coexistence with nature. They are also in charge of monitoring wastewater disposal and pollution levels. This branch is closely related to ecology.

• Discuss the importance of light in different bodies of water. 
• Aftermath of building the Hetch Hetchy valley dam. 
• The devastating impact of deforestation in the Amazon. 
• Analyze the consequences of desertification. 
• How do genetically modified insects influence the environment? 
• What would happen if all the bees die? 
• Compare several methods of wastewater disposal. 
• What were the ecological effects of Indonesia’s Mega Rice Project? 
• The Great Pacific Garbage Patch: will we ever get rid of it? 
• How do worms indicate the state of an ecosystem? 
• Why is it important to conserve biodiversity? 
• DDT: how did it affect wildlife in the US? 
• What causes toxic algae bloom? 
• Compare the adverse health effects of common contaminants in the air. 
• The Aral Sea: how did it disappear? 
• How do genetically engineered crops impact the environment? 
• Indoor air pollution: causes and risks. 
• The pros and cons of using natural gas . 
• Trace the ecological footprint of cotton production. 
• What are the ways to ensure food security without harming the environment? 

🐬 Marine Biology Topics for a Paper

Fun fact: the vast majority of our oceans are still unobserved. Research in marine biology encompasses all organisms living close to or under water. Do you want to participate in uncovering the mysteries of the deep sea? This section is for you!

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• How does luminescence in marine vertebrae work? 
• Dolphins: how do they communicate? 
• The impact of military sonar on whales. 
• What makes the Galapagos Islands so unique? 
• Compare different camouflage techniques of marine animals. 
• How do aquatic organisms live together in coral reefs ? 
• Causes of high mercury concentrations in fish. 
• Investigate the impact of overfishing in China. 
• Explain how rising sea temperatures affect marine life. 
• Contrast the survival strategies of various penguin species. 
• The ethics of seafood farms. 
• Examine bacteria’s contribution to biological processes in the sea. 
• What are the types of invasive species? 
• The contribution of birds to a stable marine ecosystem. 
• Identify the biggest threats to marine biodiversity. 
• Inspect the predatory behavior of starfish. 
• How do corals form? 
• The importance of phyto- and zooplankton to ponds. 
• Whales: how did they evolve? 
• What are the four types of oceanography ? 

🌻 Plant Biology Research Topics

Plant biology, you guessed it, investigates plants. These green organisms are incredibly versatile. From redwood trees to algae, plants come in all sizes and shapes. Scientists use botanical knowledge to improve our food and medicine supplies. They also help to conserve forests, parks, and wilderness areas.

• What causes diseases in plants? 
• What are the benefits of studying algae ? 
• Recently, scientists engineered a plant to glow by itself. How does it work? 
• What makes some plants toxic? 

• Compare various defense mechanisms of flowers. 
• Deciduous trees: what are the advantages of leaf loss? 
• How do Butterworts acquire nutrition? 
• Carnivorous plants: methods of luring prey. 
• Types of negative feedback in plants. 
• Give examples of thigmotropism. How does it work? 
• What problems are associated with the definition of kingdoms? 
• Investigate the anatomical structure of plant roots. 
• Phytohormones: how do they influence plant growth? 
• Plants and music: does sound have any measurable effects on plant development? 
• How do plants produce starch? 
• Why do weeds grow excessively? 
• Investigate plant disease management and intervention. 
• Industrial applications of synthesized plant mechanisms. 
• Cacti: how do they survive in the desert? 
• Examine the biological properties of medicinal herbs. 

🧬 Hot Topics in Evolutionary Biology to Write About

Evolutionary biologists observe change in all living organisms. If you want to know why life on Earth is so versatile, evolutionary biology has the answer. Research areas cover ecology and genetics, as well as paleontology.

• How does stabilizing selection ensure the same phenotype for a species during evolution? 
• Discuss Tinbergen’s four questions. 
• What are the benefits of sexual reproduction ? 
• Cancer: why does it persist? 
• Society and evolution: are they connected? 
• Southeast Asia and the limited occurrence of the alcohol dehydrogenase gene. 
• Is there a scientific reason to divide humans into races? 
• Track the evolution of aging throughout human history. 
• How does speciation work? 
• Genetic drift and its effects on variation. 
• Describe problems concerning the Modern Synthesis. 
• Selective sweeps: how likely are they to cause disease? 
• What does the Red Queen hypothesis state? 
• How do you determine age in herbaceous plants? 
• Life history theory: how does a species’ life history influence its evolution? 
• What are the ways for a species to achieve its maximum fitness? 
• How did the bees learn to communicate information by dancing? 
• Investigate the evolution of stamina in animal locomotion. 
• How does an animal’s physiology adapt to its geographic range? 
• Compare the evolutionary process of endotherms and ectotherms. 

👶🧑 Developmental Biology Research Topics

When animals and plants grow, their features change. It’s no surprise: every living being starts as a single cell. It’s a long way from there to a fully formed organism! Developmental biologists track this process at different levels.

• Why are men more likely to be colorblind than women? 
• What is phylogenetic niche conservatism? 
• Identify origins of congenital disorders. 
• What causes birds to become territorial? 
• Explain the two types of developmental mechanisms. 
• Why does getting older make humans more susceptible to cancer? 
• Homeotic genes: how do they influence the development of body structures? 
• Describe the advantages of apoptosis . 
• What causes polycephaly? 
• How do stem cells differentiate? 
• Investigate regeneration in hydra. 
• Mechanisms of metamorphosis in frogs. 
• What happened during the Cambrian explosion? 
• How do plants produce new structures? 
• Examine the process of neurulation in fish. 
• What are the types of deformations found in plants? 
• Describe the ABC model of flower development. 
• Why are zebrafish good model systems for developmental studies? 
• Search for the origins of the vertebrate body plan. 
• What does the concept of morphogen gradient say about the fate of cells? 

😷 Epidemiology & Population Topics in Biology

Investigating health-related events is a part of epidemiologic research. The goal is to find out what causes diseases in a specific population. Epidemiology analyzes other health issues such as natural disasters and injuries. Population biology focuses on the interaction between populations and their environment.

• How does evolutionary game theory describe the development of a population? 
• When is a strategy evolutionarily stable? 
• How does phenotypic variety in plants help manage disease? 
• What diseases are caused by heavy metal pollution? 

• How did the Coronavirus pandemic contribute to a rise in cases of domestic violence ? 
• Reasons for an increased rate of congenital disabilities in a specific area. 
• Asian carp: a harmful disruption of the marine population in American rivers. 
• Compare the three kinds of population distribution. 
• Examine the consequences of the 1783 Laki eruption. 
• Examine various policies to moderate population growth . 
• How do predator-prey dynamics work? 
• Avoidance mechanisms of resource competition. 
• Describe the three types of symbiotic relationships . 
• How does a species regulate its abundance? 
• What happens if the equilibrium state of a community is disturbed? 
• Factors that encourage human population growth. 
• Contrast the survivorship curves of humans, birds, and trees. 
• Obesity : causes and solutions. 
• Depression : how does it affect society? 
• The role of causal inference in epidemiological studies . 

📜 History of Biology Topics to Write About

Even before the emergence of scientific studies, humans had basic biological understanding. They were able to spot edible plants and domesticate animals. Assyrians and Babylonians were the first to implement biological knowledge. If you’re looking for a theoretical research project, this is the right research area for you.

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• Explore the medical knowledge available in ancient China. 
• The history of agriculture in India. 
• How did the Greek philosophers theorize about the origin of life? 
• Investigate the theory of the four humors. 
• Aristotle’s classification of animals. 
• Give an overview of discoveries in Galen’s medical writings. 
• What caused the stagnation in scientific progress during the Middle Ages? 
• Al-Jahiz’ discovery of the relationships between organisms . 
• Albertus Magnus: what was his contribution to botany? 
• How did Italy become the center for biological studies? 
• What factors impacted the development of biology during the Renaissance? 
• Trace the origins of modern anatomy. 
• What led to the establishment of the cell theory? 
• Jump starting biological progress: the invention of the microscope. 
• Louis Pasteur and the dismissal of spontaneous generation. 
• How did the discovery of heredity influence modern biology? 
• What led to the discovery of blood circulation? 
• How did the Royal Society of London impact scientific development in Europe? 
• What technology helped advance biological research in the 20th century? 
• The rise of bioinformatics: boosting progress in genetic data analysis. 

We hope our article gave you some useful ideas for your biology paper. Good luck with your assignment!

You might also be interested in:

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• What is Biology?: NTNU
• High School Biology: Khan Academy
• Microbiology: University of Pittsburgh
• Human Biology: University at Albany
• Explore Topics Related to Cells: NIH
• What Is Marine Biology?: MarineBio Conservation Society
• Developmental Biology: Stanford Encyclopedia of Philosophy
• Introduction to Epidemiology: Centers for Disease Control & Prevention
• The History of Biology: Encyclopedia Britannica
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Published by Robert Bruce at August 29th, 2023 , Revised On September 5, 2023

Biology Research Topics

Are you in need of captivating and achievable research topics within the field of biology? Your quest for the best biology topics ends right here as this article furnishes you with 100 distinctive and original concepts for biology research, laying the groundwork for your research endeavor.

Table of Contents

Our proficient researchers have thoughtfully curated these biology research themes, considering the substantial body of literature accessible and the prevailing gaps in research.

Should none of these topics elicit enthusiasm, our specialists are equally capable of proposing tailor-made research ideas in biology, finely tuned to cater to your requirements. 

Thus, without further delay, we present our compilation of biology research topics crafted to accommodate students and researchers.

Research Topics in Marine Biology

• Impact of climate change on coral reef ecosystems.
• Biodiversity and adaptation of deep-sea organisms.
• Effects of pollution on marine life and ecosystems.
• Role of marine protected areas in conserving biodiversity.
• Microplastics in marine environments: sources, impacts, and mitigation.

Biological Anthropology Research Topics

• Evolutionary implications of early human migration patterns.
• Genetic and environmental factors influencing human height variation.
• Cultural evolution and its impact on human societies.
• Paleoanthropological insights into human dietary adaptations.
• Genetic diversity and population history of indigenous communities.

Biological Psychology Research Topics 

• Neurobiological basis of addiction and its treatment.
• Impact of stress on brain structure and function.
• Genetic and environmental influences on mental health disorders.
• Neural mechanisms underlying emotions and emotional regulation.
• Role of the gut-brain axis in psychological well-being.

Cancer Biology Research Topics 

• Targeted therapies in precision cancer medicine.
• Tumor microenvironment and its influence on cancer progression.
• Epigenetic modifications in cancer development and therapy.
• Immune checkpoint inhibitors and their role in cancer immunotherapy.
• Early detection and diagnosis strategies for various types of cancer.

Also read: Cancer research topics

Cell Biology Research Topics

• Mechanisms of autophagy and its implications in health and disease.
• Intracellular transport and organelle dynamics in cell function.
• Role of cell signaling pathways in cellular response to external stimuli.
• Cell cycle regulation and its relevance to cancer development.
• Cellular mechanisms of apoptosis and programmed cell death.

Developmental Biology Research Topics 

• Genetic and molecular basis of limb development in vertebrates.
• Evolution of embryonic development and its impact on morphological diversity.
• Stem cell therapy and regenerative medicine approaches.
• Mechanisms of organogenesis and tissue regeneration in animals.
• Role of non-coding RNAs in developmental processes.

Also read: Education research topics

Human Biology Research Topics

• Genetic factors influencing susceptibility to infectious diseases.
• Human microbiome and its impact on health and disease.
• Genetic basis of rare and common human diseases.
• Genetic and environmental factors contributing to aging.
• Impact of lifestyle and diet on human health and longevity.

Molecular Biology Research Topics 

• CRISPR-Cas gene editing technology and its applications.
• Non-coding RNAs as regulators of gene expression.
• Role of epigenetics in gene regulation and disease.
• Mechanisms of DNA repair and genome stability.
• Molecular basis of cellular metabolism and energy production.

Research Topics in Biology for Undergraduates

• 41. Investigating the effects of pollutants on local plant species.
• Microbial diversity and ecosystem functioning in a specific habitat.
• Understanding the genetics of antibiotic resistance in bacteria.
• Impact of urbanization on bird populations and biodiversity.
• Investigating the role of pheromones in insect communication.

Synthetic Biology Research Topics 

• Design and construction of synthetic biological circuits.
• Synthetic biology applications in biofuel production.
• Ethical considerations in synthetic biology research and applications.
• Synthetic biology approaches to engineering novel enzymes.
• Creating synthetic organisms with modified functions and capabilities.

Animal Biology Research Topics 

• Evolution of mating behaviors in animal species.
• Genetic basis of color variation in butterfly wings.
• Impact of habitat fragmentation on amphibian populations.
• Behavior and communication in social insect colonies.
• Adaptations of marine mammals to aquatic environments.

Also read: Nursing research topics

Best Biology Research Topics 

• Unraveling the mysteries of circadian rhythms in organisms.
• Investigating the ecological significance of cryptic coloration.
• Evolution of venomous animals and their prey.
• The role of endosymbiosis in the evolution of eukaryotic cells.
• Exploring the potential of extremophiles in biotechnology.

Biological Psychology Research Paper Topics

• Neurobiological mechanisms underlying memory formation.
• Impact of sleep disorders on cognitive function and mental health.
• Biological basis of personality traits and behavior.
• Neural correlates of emotions and emotional disorders.
• Role of neuroplasticity in brain recovery after injury.

Biological Science Research Topics: 

• Role of gut microbiota in immune system development.
• Molecular mechanisms of gene regulation during development.
• Impact of climate change on insect population dynamics.
• Genetic basis of neurodegenerative diseases like Alzheimer’s.
• Evolutionary relationships among vertebrate species based on DNA analysis.

Biology Education Research Topics 

• Effectiveness of inquiry-based learning in biology classrooms.
• Assessing the impact of virtual labs on student understanding of biology concepts.
• Gender disparities in science education and strategies for closing the gap.
• Role of outdoor education in enhancing students’ ecological awareness.
• Integrating technology in biology education: challenges and opportunities.

Biology-Related Research Topics

• The intersection of ecology and economics in conservation planning.
• Molecular basis of antibiotic resistance in pathogenic bacteria.
• Implications of genetic modification of crops for food security.
• Evolutionary perspectives on cooperation and altruism in animal behavior.
• Environmental impacts of genetically modified organisms (GMOs).

Biology Research Proposal Topics

• Investigating the role of microRNAs in cancer progression.
• Exploring the effects of pollution on aquatic biodiversity.
• Developing a gene therapy approach for a genetic disorder.
• Assessing the potential of natural compounds as anti-inflammatory agents.
• Studying the molecular basis of cellular senescence and aging.

Biology Research Topic Ideas

• Role of pheromones in insect mate selection and behavior.
• Investigating the molecular basis of neurodevelopmental disorders.
• Impact of climate change on plant-pollinator interactions.
• Genetic diversity and conservation of endangered species.
• Evolutionary patterns in mimicry and camouflage in organisms.

Biology Research Topics for Undergraduates 

• Effects of different fertilizers on plant growth and soil health.
• Investigating the biodiversity of a local freshwater ecosystem.
• Evolutionary origins of a specific animal adaptation.
• Genetic diversity and disease susceptibility in human populations.
• Role of specific genes in regulating the immune response.

Cell and Molecular Biology Research Topics 

• Molecular mechanisms of DNA replication and repair.
• Role of microRNAs in post-transcriptional gene regulation.
• Investigating the cell cycle and its control mechanisms.
• Molecular basis of mitochondrial diseases and therapies.
• Cellular responses to oxidative stress and their implications in ageing.

These topics cover a broad range of subjects within biology, offering plenty of options for research projects. Remember that you can further refine these topics based on your specific interests and research goals.

Frequently Asked Questions 

What are some good research topics in biology?

A good research topic in biology will address a specific problem in any of the several areas of biology, such as marine biology, molecular biology, cellular biology, animal biology, or cancer biology.

A topic that enables you to investigate a problem in any area of biology will help you make a meaningful contribution. 

How to choose a research topic in biology?

Choosing a research topic in biology is simple. 

Follow the steps:

• Generate potential topics. 
• Consider your areas of knowledge and personal passions. 
• Conduct a thorough review of existing literature.
•  Evaluate the practicality and viability. 
• Narrow down and refine your research query. 
• Remain receptive to new ideas and suggestions.

Who Are We?

For several years, Research Prospect has been offering students around the globe complimentary research topic suggestions. We aim to assist students in choosing a research topic that is both suitable and feasible for their project, leading to the attainment of their desired grades. Explore how our services, including research proposal writing , dissertation outline creation, and comprehensive thesis writing , can contribute to your college’s success.

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49 Most Interesting Biology Research Topics

August 21, 2023

In need of the perfect biology research topics—ideas that can both showcase your intellect and fuel your academic success? Lost in the boundless landscape of possible biology topics to research? And afraid you’ll never get a chance to begin writing your paper, let alone finish writing? Whether you’re a budding biologist hoping for a challenge or a novice seeking easy biology research topics to wade into, this blog offers curated and comprehensible options.

And if you’re a high school or transfer student looking for opportunities to immerse yourself in biology, consider learning more about research opportunities for high school students , top summer programs for high school students , best colleges for studying biomedical engineering , and best colleges for studying biology .

What is biology?

Well, biology explores the web of life that envelops our planet, from the teeny-tiny microbes to the big complex ecosystems. Biology investigates the molecular processes that define existence, deciphers the interplay of genes, and examines all the dynamic ways organisms interact with their environments. And through biology, you can gain not only knowledge, but a deeper appreciation for the interconnectedness of all living things. Pretty cool!

There are lots and lots of sub-disciplines within biology, branching out in all directions. Throughout this list, we won’t follow all of those branches, but we will follow many. And while none of these branches are truly simple or easy, some might be easier than others. Now we’ll take a look at a few various biology research topics and example questions that could pique your curiosity.

Climate change and ecosystems

The first of our potentially easy biology research topics: climate change and ecosystems. Investigate how ecosystems respond and adapt to the changing climate. And learn about shifts in species distributions , phenology , and ecological interactions .

1) How are different ecosystems responding to temperature changes and altered precipitation patterns?2) What are the implications of shifts in species distributions for ecosystem stability and functioning?

2) Or how does phenology change in response to climate shifts? And how do those changes impact species interactions?

3) Which underlying genetic and physiological mechanisms enable certain species to adapt to changing climate conditions?

4) And how do changing climate conditions affect species’ abilities to interact and form mutualistic relationships within ecosystems?

Microbiome and human health

Intrigued by the relationship between the gut and the rest of the body? Study the complex microbiome . You could learn how gut microbes influence digestion, immunity, and even mental health.

5) How do specific gut microbial communities impact nutrient absorption?

6) What are the connections between the gut microbiome, immune system development, and susceptibility to autoimmune diseases?

7) What ethical considerations need to be addressed when developing personalized microbiome-based therapies? And how can these therapies be safely and equitably integrated into clinical practice?

8) Or how do variations in the gut microbiome contribute to mental health conditions such as anxiety and depression?

9) How do changes in diet and lifestyle affect the composition and function of the gut microbiome? And what are the subsequent health implications?

Urban biodiversity conservation

Next, here’s another one of the potentially easy biology research topics. Examine the challenges and strategies for conserving biodiversity in urban environments. Consider the impact of urbanization on native species and ecosystem services. Then investigate the decline of pollinators and its implications for food security or ecosystem health.

10) How does urbanization influence the abundance and diversity of native plant and animal species in cities?

11) Or what are effective strategies for creating and maintaining green spaces that support urban biodiversity and ecosystem services?

12) How do different urban design and planning approaches impact the distribution of wildlife species and their interactions?

13) What are the best practices for engaging urban communities in biodiversity conservation efforts?

14) And how can urban agriculture and rooftop gardens contribute to urban biodiversity conservation while also addressing food security challenges?

Bioengineering

Are you a problem solver at heart? Then try approaching the intersection of engineering, biology, and medicine. Delve into the field of synthetic biology , where researchers engineer biological systems to create novel organisms with useful applications.

15) How can synthetic biology be harnessed to develop new, sustainable sources of biofuels from engineered microorganisms?

16) And what ethical considerations arise when creating genetically modified organisms for bioremediation purposes?

17) Can synthetic biology techniques be used to design plants that are more efficient at withdrawing carbon dioxide from the atmosphere?

18) How can bioengineering create organisms capable of producing valuable pharmaceutical compounds in a controlled and sustainable manner?

19) But what are the potential risks and benefits of using engineered organisms for large-scale environmental cleanup projects?

Neurobiology

Interested in learning more about what makes creatures tick? Then this might be one of your favorite biology topics to research. Explore the neural mechanisms that underlie complex behaviors in animals and humans. Shed light on topics like decision-making, social interactions, and addiction. And investigate how brain plasticity and neurogenesis help the brain adapt to learning, injury, and aging.

20) How does the brain’s reward circuitry influence decision-making processes in situations involving risk and reward?

21) What neural mechanisms underlie empathy and social interactions in both humans and animals?

22) Or how do changes in neural plasticity contribute to age-related cognitive decline and neurodegenerative diseases?

23) Can insights from neurobiology inform the development of more effective treatments for addiction and substance abuse?

24) What are the neural correlates of learning and memory? And how can our understanding of these processes be applied to educational strategies?

Plant epigenomics

While this might not be one of the easy biology research topics, it will appeal to plant enthusiasts. Explore how epigenetic modifications in plants affect their ability to respond and adapt to changing environmental conditions.

25) How do epigenetic modifications influence the expression of stress-related genes in plants exposed to temperature fluctuations?

26) Or what role do epigenetic changes play in plants’ abilities to acclimate to changing levels of air pollution?

27) Can certain epigenetic modifications be used as indicators of a plant’s adaptability to new environments?

28) How do epigenetic modifications contribute to the transgenerational inheritance of traits related to stress resistance?

29) And can targeted manipulation of epigenetic marks enhance crop plants’ ability to withstand changing environmental conditions?

Conservation genomics

Motivated to save the planet? Conservation genomics stands at the forefront of modern biology, merging the power of genetics with the urgent need to protect Earth’s biodiversity. Study genetic diversity, population dynamics, and how endangered species adapt in response to environmental changes.

30) How does genetic diversity within endangered species influence their ability to adapt to changing environmental conditions?

31) What genetic factors contribute to the susceptibility of certain populations to diseases, and how can this knowledge inform conservation strategies?

32) How can genomic data be used to inform captive breeding and reintroduction programs for endangered species?

33) And what are the genomic signatures of adaptation in response to human-induced environmental changes, such as habitat fragmentation and pollution?

34) Or how can genomics help identify “hotspots” of biodiversity that are particularly important for conservation efforts?

Zoonotic disease transmission

And here’s one of the biology research topics that’s been on all our minds in recent years. Investigate the factors contributing to the transmission of zoonotic diseases , like COVID-19. Then posit strategies for prevention and early detection.

35) What are the ecological and genetic factors that facilitate the spillover of zoonotic pathogens from animals to humans?

36) Or how do changes in land use, deforestation, and urbanization impact the risk of zoonotic disease emergence?

37) Can early detection and surveillance systems be developed to predict and mitigate the spread of zoonotic diseases?

38) How do social and cultural factors influence human behaviors that contribute to zoonotic disease transmission?

39) And can strategies be implemented to improve global pandemic preparedness?

Bioinformatics

Are you a data fanatic? Bioinformatics involves developing computational tools and techniques to analyze and interpret large biological datasets. This enables advancements in genomics, proteomics, and systems biology. So delve into the world of bioinformatics to learn how large-scale genomic and molecular data are revolutionizing biological research.

40) How can machine learning algorithms predict the function of genes based on their DNA sequences?

41) And what computational methods can identify potential drug targets by analyzing protein-protein interactions in large biological datasets?

42) Can bioinformatics tools be used to identify potential disease-causing mutations in human genomes and guide personalized medicine approaches?

43) What are the challenges and opportunities in analyzing “omics” data (genomics, proteomics, transcriptomics) to uncover novel biological insights?

44) Or how can bioinformatics contribute to our understanding of microbial diversity, evolution, and interactions within ecosystems?

Regenerative medicine

While definitely not one of the easy biology research topics, regenerative medicine will appeal to those interested in healthcare. Research innovative approaches to stimulate tissue and organ regeneration, using stem cells, tissue engineering, and biotechnology. And while you’re at it, discover the next potential medical breakthrough.

45) How can stem cells be directed to differentiate into specific cell types for tissue regeneration, and what factors influence this process?

46) Or what are the potential applications of 3D bioprinting in creating functional tissues and organs for transplantation?

47) How can bioengineered scaffolds enhance tissue regeneration and integration with host tissues?

48) What are the ethical considerations surrounding the use of stem cells and regenerative therapies in medical treatments?

49) And can regenerative medicine approaches be used to treat neurodegenerative disorders and restore brain function?

Biology Research Topics – Final thoughts

So as you take your next steps, try not to feel overwhelmed. And instead, appreciate the vast realm of possibilities that biology research topics offer. Because the array of biology topics to research is as diverse as the ecosystems it seeks to understand. And no matter if you’re only looking for easy biology research topics, or you’re itching to unravel the mysteries of plant-microbe interactions, your exploration will continue to deepen what we know of the world around us.

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160 Biology Essay Topics

For most science courses, assignments are generally lab-based and rarely require much writing. However, all of that changes in biology courses when detailed essays must be written to highlight a student’s understanding of the subject. These essays are highly technical, with specific comments required to meet the factual nature of the subject.

In addition to meeting the factual requirements needed to complete the assignment, biology essays must also be written in a writing style that is informative and authoritative rather than subjective and personal.

These detailed specifics of writing a biology essay can make completing the writing difficult from the very beginning. Fortunately, we’ve created this guide to help students learn how to write a biology essay. In addition, we’ve also included 160 biology essay topics to help inspire the creative writing process.

How to Write a Biology Essay?

Writing a biology essay starts with choosing a topic. If your teacher has not already assigned a specific topic, then students must choose one that is broad enough to find credible resources and specific enough that the research won’t overtake the writing process.

To select a suitable topic for a biology essay, consider the type of biology class you are taking, the current and previous chapters studied, and the overall context of the course. These factors will help you select a topic that is likely to be relevant to your teacher’s needs and to the passing of your course.

Once students have selected a suitable topic, it’s time to research credible resources that will support the subject. To do this successfully, students need to consider the following:

• What information is already known about this topic?
• What topics are related or similar to this topic?
• Who are credible authors that can explain this topic?
• What additional sources will provide me with the information needed to complete this assignment successfully?

For example, if you want to write a biology essay on protein synthesis and its regulation at the transcriptional level, research material would include books, articles, and other written works published by credible authors or publishers. While important, this material isn’t the only type of research that should be completed.

Students may also consider consulting medical and biology dictionaries, textbooks, online research databases such as PubMed or Medline, and professional organizations for biologists to find additional sources. Once the research has been completed, it’s time to create the first draft of the biology essay.

Biology Essay Introduction

Starting an essay is always the same. Students should open with a catchy hook statement that introduces an interesting fact, presents a unique perspective, or raises a thought-provoking question.

Once that sentence has been created, students can use the middle part of the introduction to introduce fundamental concepts and provide background details about the topic.

Once that information has been laid out, and the reader knows the necessary details to make the reading interesting and worthwhile, students should move into the final portion of the introduction that answers the question: WHY is this essay important? This question is answered in the form of a thesis statement that details the essay’s overall purpose.

Biology Essay Body Paragraphs

The body paragraphs of your essay will contain the bulk of your research. Be sure that each body paragraph meets the following requirements:

• One clear idea represented per paragraph or section
• Examples that back up the point of the paragraph
• A clear and logical flow between paragraphs with transition words

Make sure that the body paragraphs only contain information pertinent to the subject or topic. Avoid fluff or filler words and phrases that don’t add any substance or value to the writing.

The number of paragraphs in the body may vary depending on the assignment parameters and the essay style. For example, an essay with a 1000 word limit won’t have as many body paragraphs as an essay with a high word count.

Additionally, a compare and contrast essay that examines the similarities and differences between two or more biology concepts may have more body paragraphs than an argumentative essay.

Biology Essay Conclusion

The final section of a biology essay is the conclusion. In this section, students need to summarize the major points of the essay and the overall purpose for writing it. The thesis should also be re-stated to recap what has been learned from the writing.

In addition to these sentences, students should include a final remark about their research and findings. This might be a thought that ties into the intro or another interesting angle that presents a new way of looking at your topic.

Once the conclusion is completed, students should edit and review their work. Make sure that the essay is free of grammar and spelling mistakes before submitting it for grading.

When it comes to choosing a biology essay topic, it is not always as easy as it seems. For students looking for help with writing a biology essay, we have compiled a list of 160 biology essay topics that will hopefully give you some great ideas.

Biology Essay Topics About Animals

• What is the importance of bats in our ecosystem?
• What is the difference between a domesticated cat and a wildcat?
• How do animals adapt to their environments?
• What are the various types of symbiotic relationships found in nature?
• Which animals have been known to show altruism towards other species?
• What impact does human activity have on animal behavior?
• What are some of the advantages and disadvantages of zoos?
• How do animal brains work?
• What is an animal’s anatomical structure like?
• What are some symbiotic relationships between humans and animals?
• What is the difference between herbivores, carnivores, omnivores, and insectivores?
• Why are having pets important to humans?
• What are the positive and negative impacts of commercial farming on animals?
• Do you think it is acceptable to keep pets in zoos? Why or why not?
• What are some common misconceptions about cats, dogs, rodents, cows, sheep, horses, reptiles/fish/insects?
• How do animal bones support their body structure?
• What are the effects of humans on the natural habitats of animals?
• What are some ways in which animal anatomy is similar to human biology?
• What are some symbiotic relationships found in the animal kingdom?
• Can humans and animals communicate with each other?
• How do different types of animal cells function differently than human cells?
• Why do some animals see better in the dark?
• Explain the circulatory system of cold-blooded animals and how it differs from that of warm-blooded animals.
• What are some examples of mimicry in nature?

Biology Essay Topics About Cellular Biology

• How does cell theory apply to cellular biology?
• What is mitosis, and where does it take place?
• What are the different parts of a cell?
• What is a nucleolus?
• What are the differences between prokaryotic and eukaryotic cells?
• How do viruses affect our cells?
• How does photosynthesis work?
• Why is it important to study cellular biology as a foundation for other disciplines of biology?
• What are the functions of organelles in cells?
• What is anabolism and catabolism?
• How do plants use photosynthesis to produce sugar while animals break down food for energy?
• Describe the process of homeostasis and explain how the human body maintains its internal environment.
• What are the important parts of a cell?
• How do cells reproduce?
• What is the difference between mitosis and meiosis?
• What is the importance of cellular research to humans?
• Explain mitochondria, chloroplasts, and vacuoles in plant cells.
• What are some of the problems with using stem cells in medical research?
• What are the differences between eukaryotic and prokaryotic organisms?
• How do humans reproduce sexually?
• Why is it different to clone plants than animals?
• What are some important functions of membranes in cells?
• What is the significance of mass spectrometry to molecular biology and genetics?
• How do viruses reproduce?
• What are mitochondria responsible for in eukaryotic cells?
• What is the difference between a plasmid and a virus?
• Do you think cloning animals should be allowed? Why or why not?
• What is a cell cycle?
• How do diseases affect the structure and function of cells?
• What are some ethical issues with genetic engineering?
• What is cell division, and how does it work?
• Where does meiosis occur in the body, and what does it accomplish?
• Explain the structure and function of ribosomes in eukaryotic cells.
• What is a cell membrane made up of, and what are its important structural components?
• How do antibiotics affect bacterial cells?
• Do you think cloning humans should be allowed? Why or why not?
• What makes up the cytoskeleton?
• How are molecular structures related to the functions of cells?
• What are some examples of biomolecules necessary for cell function and survival?
• What types of molecules make up an organism’s genome?

Biology Essay Topics About the Ecosystem

• What does the term food web mean?
• Why is it important to study population dynamics in an ecosystem?
• How do humans affect other species and their environments?
• How can we prevent and control invasive species, and why are they so dangerous?
• What effects does pollution have on animals and their habitats?
• How do global warming and climate change affect the ecosystem?
• What are the different types of animals found in ecosystems?
• What happens to an ecosystem when one species becomes extinct?
• What is the difference between biotic and abiotic components of an ecosystem?
• How do humans feed off other species to survive?
• Describe how the r-selected life strategy works.
• What are some examples of symbiosis found in nature?
• How does biodiversity affect the structure, function, and survival of ecosystems?
• How does the stability of an ecosystem depend on biodiversity?
• What are trophic levels, and how do they function to maintain the structure of ecosystems?
• Why are invasive species dangerous?
• How do global climate changes and human activities affect the biodiversity of ecosystems?
• What types of organisms thrive in wetlands?
• How do humans benefit from studying ecosystems?
• What ecosystems are best suited to rapid climate change?

Biology Essay Topics About Evolution

• Is evolution strictly a scientific theory, or is it also valid spiritually?
• Why is research about the evolution of life important to our understanding of the past?
• What are some examples of convergent evolution?
• How does natural selection contribute to evolution?
• Why is it important for people to understand evolution and its role in biology?
• What are some benefits that humans enjoy thanks to evolution?
• How do mass extinctions impact the evolution of different species?
• How does a mutation affect a population’s gene pool and diversity?
• Explain the core principles of Darwin’s theory of evolution.
• How does an organism’s ability to respond to environmental changes contribute to its rate of evolution?
• What is polyphyletic evolution?
• What are some examples of vestigial traits in humans and other species?
• How do eco-evolutionary dynamics play a role in evolution?
• Do you think that past mass extinction events had an impact on evolution? Why or why not?
• What are some benefits humans enjoy thanks to evolution by natural selection?
• How could modern-day diets affect the evolutionary growth of humans?
• What animals have had evolutionary changes based on threats to their diets?
• What evolutionary response makes for the best camouflage?
• What types of traits can be used to differentiate between closely related species?
• What are the main factors that prevent a population from evolving?
• How is artificial selection different from natural selection?
• Why do scientists still debate about evolutionary theory despite overwhelming evidence supporting it?
• What are some examples of convergent evolution in nature, and how do they function as an adaptation?
• Why is research about the evolution of life important to understanding the past?

Biology Essay Topics About Genetics

• What is genetic drift, and how can it lead to changes in a population over time?
• How do the different parts of DNA interact with each other?
• How are dominant and recessive traits identified?
• What are some examples of genetic disorders?
• What causes Down syndrome, and how is it diagnosed in children?
• How does natural selection act on mutations to create variation in a population?
• Can scientists use DNA testing to learn about our ancestors’ migratory patterns and where they lived?
• How can animal migration help us to better understand genetics?
• Define molecular genetics and explain how it relates to classical and Mendelian genetics.
• What is the Hardy-Weinberg equilibrium, and why is it important in population genetics?
• Do you believe that scientists should clone human beings? Why or why not?
• Why are dominant traits sometimes called masking genes?
• Why is genetic diversity important for long-term species survival?
• How are epigenetic changes related to evolution?
• What is the difference between gene expression and gene activity with regards to genetics?
• How do developmental genes affect the appearance of an organism throughout its life cycle?
• How have animal and plant breeders used genetic engineering to produce certain types of hybrids?
• What are the ethical implications of human cloning?
• What are the latest technologies in genetic engineering?
• What new technologies are needed to make human cloning a reality?
• How are living organisms adapting to the presence of plastics in our environment?
• Why are some individuals resistant to certain genetically programmed diseases?
• What are three common misconceptions about genetic engineering?
• What is transgenic technology, and how can it be used for disease prevention or treatment?
• How do microorganisms impact human health and the environment?
• What are some examples of a genetically modified organism?
• How does natural selection impact microorganisms?
• What is DNA profiling, and how can it help to solve crimes or return missing persons to their families?
• Why do scientists need more research surrounding epigenetics before drawing conclusions on its effects on evolution?

Biology Essay Topics About the Human Body

• What is the purpose of skeletal and respiratory systems?
• How do hormones affect our body on a daily basis?
• How does the endocrine system work as part of an overall regulatory system in the human body?
• What are some different types of cells found in the human body?
• What are the differences between exocrine and endocrine glands?
• What are stem cells, and why are they important to biological research?
• How do muscles work together to create movement in our bodies?
• How do bones help us to maintain balance while walking, standing up straight, and running?
• What are some ways that human behavior can impact our bodies?
• How do foods with high sugar content affect the digestive system?
• What organs are no longer necessary in the human body, and why?
• What blood types offer better protection from the elements?
• What are mosquitoes attracted to some humans and not to others?
• What pheromones do humans give off?
• What are the different types of blood cells?
• How does healthy eating help to maintain digestive health?
• Why do some people get migraines that others don’t seem to be bothered by?
• What is the pH level of human blood, and how can it be carefully regulated?
• How does altitude affect respiration in humans?
• What is the most complicated system in the human body?
• Explain the biological purposes of “Fight or Flight.”
• What role does the immune system play in human health?
• What is the difference between human anatomy and physiology?

Choosing any of these 160 biology essay topics will help students craft an informative and authoritative essay that is sure to earn them a passing grade.

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97 Biology Essay Topics

🏆 best essay topics on biology, ✍️ biology essay topics for college, 👍 good biology research topics & essay examples, 📌 easy biology essay topics, 🎓 most interesting biology research titles.

• How Do People Use Biology in Their Everyday Life?
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• Crime Explanation Using Biology and Psychology
• Biology as the Branch of Science
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• Homologous and Analogous Structures in Biology
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• My Journey in Biology The author of this essay is a passionate, young, and ambitious neuroscience and molecular biology learner. He describes his path in studying neuroscience.
• Biology and Culture of Gender Color Stereotypes This paper attempts to answer this question and determine whether the indicated color genders are biologically based or culturally embedded.
• Human Biology and Culture Connection The paper states that it is anthroposociogenesis that explains the dichotomy between biology and culture and the connection with human evolution.
• Role of Human Biology in Contemporary Criminal Justice Focus of analysis of the paper will be on theories developed to explain criminology with a special emphasis on Biological positivism theory
• Biology: The Definition of the Genotype The paper discusses the genotype. It is composed of a pair of alleles and it is what is manifested as the phenotype or observable characteristics of an organism.
• Transcription and Translation in Molecular Biology The Central Dogma describes the basic principles of genetic information transfer: transcription and translation. The paper distinguishes these two processes.
• Environmental Biology: Green Energy a precise definition of green energy is manifested in its source, which must be natural, such as the sun or geothermal sources.
• The Egg White Denaturation as a Concept of Biology Denaturation is the process of breaking down the secondary and tertiary structures of a protein by external factors such as temperature.
• Biology and Social Influence Genetics plays an indispensable role in facilitating inherent-acquired behaviors, while others claim the environment contributes to shaping an individual’s personality.
• Marine Biology: Description and the Key Features Marine Biology is an open area of the coast line that is exposed to ocean currents and tides. This is a backwater area with occasional flooding of sea water.
• Cell Biology: Cell Sizes, Types, and Theories The Cell Theory propounds that all organisms are made of cells, the cell is the basic unit of life and all cells descend from older cells.
• Concepts of Biology: HIV and AIDS The primary purpose of the paper is to examine the symptoms and the effects that HIV and AIDS have on a human being.
• Biology: Comparison and Contrast of Cats and Dogs It is important to discuss the eating habits of cats and dogs. In particular, one should mention that they are mammals, and they are fed with milk during childhood.
• Biology: Aspects of Fruits The paper discusses fruits. A fruit is the fleshy and sweet part of a tree or any flowering plant that contains seeds. Some fruits are poisonous while some are edible.
• Organismal Biology: Succession and Its Characteristics Succession is an ecological phenomenon during which a successive change of biological communities occurs in a particular territorial area over time.
• Atoms and Molecules as Concepts in Biology Atoms are the fundamental building block of chemical elements and the smallest unit into which matter can be divided.
• Molecular Biology and Its Central Dogma The central dogma of molecular biology is a principle describing the transfer of molecular information in the Nucleus of the DNA.
• Herbert Spencer – Scientists of Biology Herbert Spencer is one of the outstanding scientists belonging to the sphere of biology, sociology, and anthropology.
• An Aspect of Evolutionary Biology as Phylogenetic Analysis The paper explores an aspect of evolutionary biology as phylogenetic analysis. Phylogenetic analysis is a tool in the hands of biologists.
• Human Biology – Scientific Method In the study of biology, knowledge of proteins is very important as it enables a person to make informed decisions while choosing a balanced diet.
• Human Biology: Genes and Genes Mutations Mutations in certain regions of DNA can cause pathological metabolic abnormalities or hereditary features realized through dysfunctional disorders.
• Human Biology Review Essay of Our Body, Every Cells The collection of like cells that have an identical origin that carries out a definite function together is what I am.
• Is PCR the Most Important Invention in Molecular Biology to Date? This essay provides different reasons that have made the PCR technique a significant invention in molecular biology to date.
• Cancer Biology: Oncogenes and Tumor Suppressor Genes This paper seeks to interpret the role oncogenes and tumor suppressors play in transformation during cancer formation.
• Biology Food Chain The body coordination in an organism are carried out in the central nervous system that depends entirely on the neurons conducted from the receptor sites to the effectors’ sites in the body.
• Biochemistry and Molecular Biology Are Fundamental to the Life Sciences Some molecules are often recognized as building blocks for cell formation, implying that they are fundamental to the physiology of humans.
• “Genbank” Impact on Modern Molecular Biology Research GenBank is the fundamental element of Molecular biology. It is the sequence formed and stored in the database of the entire genome of life.
• Conservation Biology and Preservation of the Biodiversity The Theory of Island Biogeography is the most significant contribution toward the scientific understanding of both the process and how to measure the rate of species extinction.
• Biology Lab: Why Ice Floats Ice is usually considered to be a mineral that consists of hydrogen oxide; when ice is frozen at a constant pressure of 1 atmosphere, the resultant effect.
• Mirror-Image Biology to Enhanced Therapeutic Proteins The concepts described in “From Mirror-Image Biology to Enhanced Therapeutic Proteins” exemplify the potential of cell chemical biology generally and mirror-image forms.
• Biology: Application of the Holobiont in Humans When it comes to the formation of a unique environmental unit, a holobiont can link an individual host to a variety of interactive microorganisms and microbiota.
• Biology. Glial Cells and Their Subtypes Due to the distinctive features of some glial cells, they are divided into different subtypes, including ependymal cells, oligodendrocytes and astrocytes, and microglia cells.
• Biology and Happiness Relationship Human beings engage in numerous activities, establish appropriate relationships, and formulate decisions that can eventually make them happy.
• Psychobiology: Biology of Behavior This report researches to what extent psychological and physiological factors influence a person’s character, reactions, and behavior using findings of psychobiology.
• Biology Postgraduate Education and Its Advantages If you want to become a biologist in the future or just want to evaluate the pros of this occupation, this article may become more than useful for you.
• Biology: Mechanical Signals Regulating Development The paper will highlight several control effects of mechanical forces on various cell activities, including early embryonic development, tissue morphogenesis, and organ formation.
• Cultural Variations in Environment and Biology: AIDS The research studies the prevalence of AIDS among ethnic groups in the United States and suggests patient education interventions, which can be performed by nurses.
• Cancer Risk Factors: Biology Concepts The development of cancer cells is associated with the halting of the process of cell generation and decay that may be considered one of the basic aspects of the physical health.
• Substance Abuse: Environmental Influences and Biology Substance abuse is not a new problem the human society faces. This paper examines different ways biological and environment influences interact and affect drug taking behavior.
• Happiness in Biology, Culture, Experience It isn’t easy to understand what happiness is. However, it is still possible to identify some factors that are likely to affect the degree of happiness.
• Bringing Culture Into Human Biology and Biology Back Into Anthropology
• The Relationship Between Evolutionary Biology and Religion
• Cell Biology of Stem Cells: An Enigma of Asymmetry and Self-Renewal
• An Intricate Relationship Between Biology and Art
• Computing Has Changed Biology: How Biology Education Can Catch Up
• Common Ground Between Anthropology and Conservation Biology
• The Evolution of Molecular Biology Into Systems Biology
• Scientific and Public Functions of Models in the 19th-Century Biology
• Biology and Ethics: The Paradoxes of the Natural
• Use, Overuse, and Misuse of Significance Tests in Evolutionary Biology
• The Autonomy of Biology: The Position of Biology Among the Sciences
• Joseph Gottlieb Kolreuter’s Contributions to Biology
• Chemical Bridge Between Ecosystem Ecology and Evolutionary Biology
• The Ethics of Biological Studies With Living Organisms
• Biological Function and Teleology: Implications for Biology Education
• Adaptationism and the Challenge From Developmental Biology
• Quality Assured Science: Managerialism in Forensic Biology
• Essence and Natural Kinds in Aristotle’s Biology: Was It Sexist?
• The Biological Weapons Convention: Securing Biology in the 21st Century
• Molecular Biology Techniques Used in Wastewater Treatment
• The Biology of Stupidity: Genetics, Eugenics, and Mental Deficiency
• Existentialism and Feminism: The Rhetoric of Biology in the Second Sex
• Kant, Blumenbach, and Vital Materialism in German Biology
• How the Mind Grows: A Developmental Perspective on the Biology of Cognition
• Biology and Society in the Age of Enlightenment
• Negotiating the Place of Molecular Evolution Within Evolutionary Biology
• Global Change: Increasing the Success of Biological Invaders?
• On the Relations Between History and Philosophy of the Life Sciences and Biology
• Civic Biology: The Origin of the School Anti-Evolution Movement
• Reductionism in Biology: Prospects and Problems
• Factors Shaping Ernst Mayr’s Concepts in the History of Biology
• Building Simulations: Modeling and Theory in Systems Biology
• The Role of Information Technology in Biology Education
• What Difference Does Quantity Make: On the Epistemology of Big Data in Biology
• Causality, Teleology, and Thought Experiments in Biology
• Applying the Principles of Stem-Cell Biology to Cancer
• The Moral Impact of Synthesizing Living Organisms: Biocentric Views on Synthetic Biology
• Applying Evolutionary Biology to Address Global Challenges
• Water as an Active Constituent in Cell Biology
• The Importance of Feminist Critique for Contemporary Cell Biology
• Marine Molecular Biology as an Emerging Field of Biological Sciences
• Trends, Priorities, and Needs in Systematic and Evolutionary Biology
• Development of Biology in Aristotle and Theophrastus: Theory of Spontaneous Generation
• Why Values Are a Good Thing in Conservation Biology
• Biology and Equality: A Perspective on Sex Differences
• Recent Advances of Deep Learning in Bioinformatics and Computational Biology
• Bioimage Informatics: A New Area of Engineering Biology
• Reflecting on the History of Biology as a Field
• Molecular Biology vs. Organicism: An Enduring Dispute Between Mechanism and Vitalism
• The Role of Reductionism in the Development of Molecular Biology

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These essay examples and topics on Biology were carefully selected by the StudyCorgi editorial team. They meet our highest standards in terms of grammar, punctuation, style, and fact accuracy. Please ensure you properly reference the materials if you’re using them to write your assignment.

This essay topic collection was updated on December 27, 2023 .

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Biology Essay Topics: 50+ Ideas for Your Next Project

by  Antony W

December 16, 2023

A Biological essay is a technical piece of assignment that requires careful topic selection, structure, and writing. So if your teacher hasn’t given you a title for the essay , you should tread carefully when choosing topics.

In this post, we share with you a list of 50+ Biology related ideas, which you may find useful and equally interesting during the brainstorming stage. You can use the list as inspiration to come up with a topic of your choice, or you can pick of these examples and modify it to your liking.

Key Takeaways 

• Because Biology is a broad subject, you should choose a topic that focuses on an interesting theme or an area that you’ve always wanted to explore.
• Check the Biology assignment prompt for guidelines on what you have to do, as these are the instructions that will inform your essay.
• Share the topic with your teacher first, so they can give you their opinion on whether it’s a suitable one to research.

50+ Best Biology Essay Topics

Below is a list of 50+ topics that you just might find useful and interesting enough to explore in your Biology essay:

Human Biology Essay Topics

• How does the mouse serve as a model for understanding human biology?
• What defines the secular trend observed in human physical growth over time?
• The significant role of medicinal plants in human life and health
• Understanding the characteristics of human biorhythms and their implications
• The interconnected circles of human blood circulation and the relationship between the respiratory and cardiovascular systems
• How do neurons interact within nerve centers, and what impact does this have?
• The influence of parental smoking, alcohol, and drug abuse on the embryonic development of a child

Controversial Biology Essay Topics

• What are the leading theories on how life initially emerged on Earth?
• Is there evidence suggesting that plants might experience something akin to pain?
• Can we determine if animals possess consciousness? 
• To what extent is animal testing essential for achieving major biological breakthroughs?
• What defines the concept of the Last Universal Common Ancestor (LUCA) in evolutionary biology?
• Where did eukaryotic life forms originate from and what evidence supports this?
• Are viruses considered living entities, and why or why not?
• What are the fundamental theories explaining the origins of the human species?
• Why has the mystery of brain function remained unsolved despite scientific advancements?
• Is it scientifically accurate to state that a fetus cannot feel pain?
• What is the current understanding of the status of Nano bacteria in biological research?

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Biology Extended Essay Topics

• How does a multicellular organism develop from a single cell?
• What are the defining characteristics of the regeneration process in living organisms?
• How does guided natural selection influence species’ evolution, and what are its implications?
• What structural and anatomical features differentiate mammals, using two representatives for comparison?
• How does catastrophe theory contribute to understanding the progression of life in nature?
• What are the biological aspects of pathogenesis in both animals and plants?
• How does self-regulation function within biological systems?
• Describe the processes involved in the reproduction and development of living systems.
• What are the fundamental organizational principles that sustain the biosphere?
• How do different forms of movement occur at the subcellular, cellular, and organism levels?

Cell Biology Essay Topics

• How do stem cells contribute to medical advancements?
• What pathways in cell biology offer promising approaches for treating Alzheimer’s disease?
• The primary research methods utilized in cell biology and how they contribute to scientific discoveries.
• How scientists study fixed objects and the insights that this approach provide. 
• The fundamental differences between DNA and RNA, and how do they function within cells.
• An overview of the structure and components that constitute a cell in biology

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Zoology Essay Topics

• What are the intricate migration patterns of birds and how do they navigate across vast distances?
• How primate language or communication systems resemble and differ from human language.
• Analyze how scientists analyze and manage the impact of invasive species on ecosystems.
• Explain how different species of animals communicate with each other.
• What historical evidence or scientific findings shed light on the domestication process of canines and its impact on their behavior and traits?
• Is there a correlation between brain size and the intelligence or cognitive abilities of different species?

Animal Research Essay Topics

• What factors contribute to the rising obesity rates among household pets?
• Ethical considerations surrounding the testing of beauty products on animals
• What cognitive functions do primates exhibit and how do these compare to human cognitive abilities?
• How do predators and prey adapt to their roles in the ecosystem and what strategies have evolved in this ongoing interaction?
• What variations exist in the vision of different animal species and how do these adaptations contribute to their survival?
• The implications of fishing practices on marine conservation efforts
• What are the consequences of removing animals from their natural habitats?

Botany Essay Topics

• What recent breakthroughs in plant research have significantly affected modern agricultural practices? 
• How do plants respond to various stressors and what physiological mechanisms enable them to adapt to adverse conditions?
• Elaborate on the structural diversity and different types of fungi.
• What recent discoveries or insights have emerged from the study of plant fossils and how do they contribute to our understanding of ancient plant life?
• How does the process of photosynthesis function in plants and what factors influence its efficiency and effectiveness?
• What are the mechanisms of genetic inheritance in plants and how do these mechanisms affect the traits and characteristics of plant species?
• What are some prevalent diseases or issues affecting plants and what methods are used to manage or prevent these problems?
• What unique characteristics define ferns, and what role do they play in the ecology and biodiversity of various habitats?

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Antony W is a professional writer and coach at Help for Assessment. He spends countless hours every day researching and writing great content filled with expert advice on how to write engaging essays, research papers, and assignments.

100 Fascinating Biology Research Paper Topics for Students

15 January, 2021

11 minutes read

Author:  Elizabeth Brown

Biology research is a serious analytical task that usually contains scientific findings, debatable questions, and detailed explanations. Students who are studying biology may get an assignment to find some interesting biological topics to do research for essays, term papers, and scientific reports.

It is quite a challenging and overwhelming task that takes pretty much time and effort. If your topic is not relevant, you won’t be able to include a scientific argument and proceed with further discussion. In this article, you will discover some topics for biology projects that will help you gain attention in a rapidly evolving field like this.

How to Choose Topic for Biology Research Paper?

Well, you’ve been researching for a while now, and you are ready to focus on a particular topic. Professors often ask students to write about something that has not been researched for a hundred times. Among all topics in biology, you should choose the one you are actually interested in. There are certain tips you need to follow before opting for your topic:

• Narrow down the subject matter. Before choosing an interesting biology topic for your research paper, you first need to identify a particular aspect of biology that interests you.
• Examine the existing research papers. You should conduct thorough research on the existing scholarly articles in order to gain a better idea about recent trends in the particular sphere of Biology.
• Brainstorm a particular area . By brainstorming ideas and thoughts, you may find the ideal research topic for biology to focus on.
• Conduct a preliminary research . By conducting preliminary research, you will check the amount of materials covering the selected topic. If you fail to find any information, you should choose another topic.
• Have a look at relevant examples . Checking credible examples is important for biology topics selection. This way, you will learn how to structure your research paper and go about the selected topic.

History of Biology

Do you consider covering the history of Biology in your research? Then, you may refer to the history of all life forms on the planet and explore how they have been researched over time. Here are some topics to dwell on:

• How archeology influences animal biology?
• The latest explanation of Darwin’s theory in modern science
• Edward Jenner and his contribution to the fight against epidemics
• The dead branches of evolution
• Exploring the importance of evolution factors
• Study of modern theories related to the origins of humankind
• The contribution of Antonie van Leeuwenhoek to the science of Biology
• The most significant milestones in the development of behavioral mechanisms in the late XIX – early XX centuries
• Can we trust the Natural Selection Theory? Does it work in the human world?
• The development of genetics over the last century

Immune System Biology Research Topics

The immune system, as our main defense against different diseases and infections, is one of the most important topics for discussion in Biology. Take a look at the following topic examples:

• The resistance capacity of the human immune system
• Why is vaccination important and what are its benefits?
• Problems caused by immunotherapy
• Effects of probiotics on  the prevention of infections
• How poor immunity leads to fatal diseases
• The functions of immune system agents
• The resistance of the human immune system
• Medical conditions caused by immune system malfunction
• How does insomnia influence the human immune system?
• Molecular biology of Human Immunodeficiency Virus

Molecular Biology Topics

Are you looking for a molecular biology issue to cover in your research paper? The following topics represent the latest research on this subject matter.

• The effective ways and tools for effective lifetime prolongation
• The role of genetically modified crops for the national economy
• Molecular biology research in the United States
• Can Ebola be viewed as a biological weapon?
• The effect on antibiotics on cells
• Challenges caused by diseases to molecular biology
• Does molecular biological research of rare genetic disorders provide us with the keys to understanding cancer and other diseases?
• What are the biological reasons behind food intolerances?
• Production of growth hormone and insulin in genetic engineering
• Molecular chaperones and their role in polypeptides folding

Genetic Researches Biology Topics

Research on genetic concepts can reveal intriguing insights into human nature and potential. The variety of options here is unlimited. Some of them include the following:

• How to solve the ethical dilemma of human cloning?
• The recent implementation of genetic disorders treatment
• Modern technology in  DNA analysis
• The process of DNA modification on smoking females
• Methods of the sequencing of nucleotide sequences of DNA
• DNA Modifications and its Effects on Humans
• Genetics of chromosomal diseases related to structural chromosome rearrangements
• Genetics behind human physical features
• DNA diagnosis of hereditary and infectious diseases
• Can DNA influence the process of aging?

Neurobiology Research Topics

The human brain is intriguing, as there are always some new things to learn. The following topics have a great study potential:

• The improvement of brain activities with the most advanced neurobiology aids
• The innovative technologies in neurobiology
• Does gut bacteria lead to depression?
• Genetic defects that cause schizophrenia
• The molecular and gene regulatory signature of a neuron
• The influence of music on cognitive processes in a human brain
• What are the negative consequences associated with neurosurgery?
• Formation of thinking, speech, and consciousness of an average person
• Neurobiological Explanation of Sleep
• The role of neuroscience in the development of robotic technologies

Plant Research Topics

Are you interested in writing a paper about plants? Here are some of the latest ideas in botany to get inspiration by: 

• How does climate change affect biodiversity in Australia?
• The evolutionary factors that affect plant growth
• A comparative analysis of invasive plants in New Zealand
• Friction in the plant world
• How modern technology can facilitate plant disease treatment
• Disease resistance mechanism in plants
• An extensive research on plant-associated microbes and available genomic tools
• Feature and functions of photosynthesis
• Impact of electric current on plant cells
• Plant cells plastids structure and function

Ecological Subjects

Ecology-concerning subjects are becoming more and more popular as society has to deal with the results of human behavior all the time. In your biology research study, you can offer some new solutions to ecological problems in order to turn the world into a better place. Let’s review some popular topic examples:

• Exploring the relevance of chemical ecology in the context of Oceania
• The impact of Ecological factors on animal behavior
• Ways animals and plants adapt to fast-changing environment
• Explore the ecological footprint of cotton production
• The ecological approach to sustainable marine research
• Why does biodiversity need to be conserved?
• Consequences of building the Hetch Hetchy valley dam
• What causes toxic algae bloom?
• Indoor air pollution: causes and risks
• The devastating impact of deforestation in Amazon forests

If you are interested in the animal world , feel free to write about it in your research paper. By conducting a deep analysis of one phenomenon or species, you may shed light on the growing problems. Some of the burning topics to consider include the following:

• How the mechanism of camouflage is used by sea animals?
• How does veganism affect meat production?
• How do humans influence the diversity of animal species?
• The mechanism of resistance in animals
• Domestication: can foxes become domestic animals?
• Possibility of homosexual connections in the world of animals
• The future of the planet through the prism of Species Extinction
• Can beauty products testing on animals be viewed as ethical?
• Evolutionary connections between moths and butterflies
• The importance of home diet for dogs

Behavior and Hormones

You can also share ideas on how human hormones influence their mood and well-being. A short list of topic samples covers the following: 

• How hormones affect women’s behavior during pregnancy
• Psychopathic Disorders: Are They Hormone-Specific?
• The hormones disorder and constant depression
• How does your brain control your behavior?
• The three main psychopathic disorders influenced by hormones
• Analyze the features of oxytocin that turn this hormone into a love drug
• How to generate growth hormone by means of genetic engineering methods?
• Biologic basis of the bipolar disorder
• The influence of diabetes and its potential threats
• The role of hormones in women’s health

Easy Biology Research Topics

If you don’t know what to write about in your biology research paper, you can use one of the most common topics. Although they have been widely covered by scientists, it doesn’t mean they are not suitable for further research. These topic ideas might come in handy:

• How to prevent the risks related to global warming?
• The future prospects of molecular biology in Europe
• Is growing organs for transplantation in laboratories ethical?
• How is melatonin used for therapy purposes?
• What is the value of sustainability in Biology?
• Explore the effects of marijuana on the human brain. Should the use of marijuana become legal?
• Accuracy of DNA testing in the modern medical environment
• Different ecological pyramids and the ratio of organisms at each of their levels
• The positive and negative aspects of transgenic crops
• Various means of wildlife protection

Biology research is one of the most complicated academic assignments that needs to be written according to strict requirements. While checking the variety of biology research topics, you should be ready to deal with certain problems, such as a poor understanding of the subject matter, its value for society, etc. Try to select a brief and concise topic that can be supported with relevant and up-to-date evidence. Make sure to conduct thorough research by using all the available tools and methods you know. Remember that the importance and timely revelation of the topic increases your chances to get an excellent grade eventually.

If you are still unsure on whether you can cope with your task – you are in the right place to get help. Our essay writers know the perfect answer to the question “Who can write my paper?”

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Ethical Research Paper Topics

Writing a research paper on ethics is not an easy task, especially if you do not possess excellent writing skills and do not like to contemplate controversial questions. But an ethics course is obligatory in all higher education institutions, and students have to look for a way out and be creative. When you find an […]

Art Research Paper Topics

Students obtaining degrees in fine art and art & design programs most commonly need to write a paper on art topics. However, this subject is becoming more popular in educational institutions for expanding students’ horizons. Thus, both groups of receivers of education: those who are into arts and those who only get acquainted with art […]

COMMUNICATION IN THE BIOLOGICAL SCIENCES Department of Biology

LITERATURE REVIEW PAPER

WHAT IS A REVIEW PAPER?

CHOOSING A TOPIC

RESEARCHING A TOPIC

HOW TO WRITE THE PAPER    

The purpose of a review paper is to succinctly review recent progress in a particular topic. Overall, the paper summarizes the current state of knowledge of the topic. It creates an understanding of the topic for the reader by discussing the findings presented in recent research papers .

A review paper is not a "term paper" or book report . It is not merely a report on some references you found. Instead, a review paper synthesizes the results from several primary literature papers to produce a coherent argument about a topic or focused description of a field.

Examples of scientific reviews can be found in:

                Current Opinion in Cell Biology

                Current Opinion in Genetics & Development

                Annual Review of Plant Physiology and Plant Molecular Biology

                Annual Review of Physiology

                Trends in Ecology & Evolution

You should read articles from one or more of these sources to get examples of how your paper should be organized.

Scientists commonly use reviews to communicate with each other and the general public. There are a wide variety of review styles from ones aimed at a general audience (e.g., Scientific American ) to those directed at biologists within a particular subdiscipline (e.g., Annual Review of Physiology ).

A key aspect of a review paper is that it provides the evidence for a particular point of view in a field. Thus, a large focus of your paper should be a description of the data that support or refute that point of view. In addition, you should inform the reader of the experimental techniques that were used to generate the data.

The emphasis of a review paper is interpreting the primary literature on the subject.  You need to read several original research articles on the same topic and make your own conclusions about the meanings of those papers.

Click here for advice on choosing a topic.  

Click here for advice on doing research on your topic.  

HOW TO WRITE THE PAPER

Overview of the Paper: Your paper should consist of four general sections:

Review articles contain neither a materials and methods section nor an abstract.

Organizing the Paper: Use topic headings. Do not use a topic heading that reads, "Body of the paper." Instead the topic headings should refer to the actual concepts or ideas covered in that section.

Example  

What Goes into Each Section:

Home  

The Best Biology Review: Topic Summaries, Examples, and Free Practice

Welcome to Albert’s collection of science topic reviews for teaching and reviewing Biology. Teachers and students can explore our easy-to-follow guides below for use at home or in the classroom .

Introduction to Biology

What is the experimental design process how do scientists study feedback loops.

The review articles below explore the basic skills needed to be successful in a high school biology course. Review SI units, the nature of science, and experimental design.

What is the difference between mitosis and meiosis? How is genetic material created and pass on?

The review articles below explore many topics related to genetics. Review mitosis, meiosis, and the mechanism of genetic transfer with helpful examples and summaries.

Anatomy and Physiology

How do we explain the body what makes each system unique.

The review articles below explore the general ins and outs of the human body. From terminology to the inner-workings of the systems, many topics are examined below.

Advanced Biology Topics

Looking to take your biology mastery to the next level.

The review articles below dive deeper into the processes behind genetics and reproduction.

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Biological sciences articles within Scientific Reports

Article 01 April 2024 | Open Access

Clinical phenotype and genetic function analysis of a family with hypomyelinating leukodystrophy-7 caused by POLR3A mutation

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The miR-183/96/182 cluster regulates sensory innervation, resident myeloid cells and functions of the cornea through cell type-specific target genes

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Extended Essay Writers

Biology EE Topics | 40 Ideas

Luke MacQuoid

There are many potential topics for a biology Extended Essay (EE) in the International Baccalaureate (IB) program.

Topic Ideas

Some possibilities include the following:

• The effects of pollution on a particular species or ecosystem.
• The genetic basis of a specific disease or trait.
• The comparative physiology of a specific mammal and bird.
• The effects of climate change on a particular species or ecosystem.
• The impact of human activity on the evolution of a species.
• The physiology of a specific plant species.
• The efficacy of a specific medicinal plant.
• The comparison of the anatomy and physiology of a specific animal species in captivity and in the wild.
• The impact of a specific invasive species on an ecosystem.
• The effect of different fertilizers on the growth and development of a specific plant species.
• The study of the symbiotic relationship between specific species.
• The effect of different light conditions on the growth and development of a specific plant species.
• The impact of different temperature conditions on the physiology of a specific microorganism.
• The study of the genetic diversity within a specific species.
• The study of the effects of different pH levels on the growth and development of a specific plant species.
• The impact of human activity on the population dynamics of a specific species.
• The study of the effects of different soil types on the growth and development of a specific plant species.
• The study of the impacts of different pesticides on the physiology of a specific species.
• The study of the effects of different water conditions on the growth and development of a specific plant species.
• The study of the impact of ocean acidification on the physiology of a specific marine species.
• Studying the Effects of Acid Rain on Local Flora.
• The Role of Gut Microbiota in Obesity.
• Influence of Insecticides on Honey Bee Population Decline.
• The Effects of Microplastics on Aquatic Food Chains.
• The Role of Genetics in Determining Human Lifespan.
• Influence of Habitat Loss on the Genetic Diversity of a Specific Species.
• The Effects of Light Pollution on Nocturnal Animals.
• A Comparative Study of Photosynthesis Rates in Different Plant Species.
• The Impact of Noise Pollution on Avian Communication.
• Analysis of Biological Controls for Invasive Species.
• The Effects of Diet on the Gut Microbiota.
• Understanding the Effect of Climate Change on Disease Vectors.
• Exploring the Role of Genetics in Athletic Performance.
• Effects of Pharmaceuticals on Aquatic Ecosystems.
• The Impact of Urbanization on Local Bird Species.
• Understanding the Relationship Between Sleep and Immune Function.
• Studying the Effects of Air Pollution on Lichen Species.
• The Role of Epigenetics in Aging.
• The Effect of Vegan and Vegetarian Diets on the Human Body.
• Investigating the Biological Mechanisms of Meditation and Mindfulness.

It’s important to note that these are just examples of topics for your IB EE in Biology . You should choose a topic that interests you and that you can find enough information on.

Need help with your Biology extended essay?

From research and analysis to structuring and editing, our skilled mentors will be by your side, helping you craft an exceptional extended essay that not only meets the stringent IB criteria but also reflects your passion for Biology studies.

Additionally, it’s essential to consult with your supervisor to make sure the topic meets the requirements of the Extended Essay and that you have access to the necessary resources to complete the research.

Students can use these themes in their essays by researching and analyzing the specific topic, providing evidence and examples to support their claims, and discussing the implications and potential solutions to the issue at hand.

For example, in an essay on the effects of pollution on a particular species or ecosystem, a student could research the specific pollutants that are affecting the species or ecosystem, analyze the effects those pollutants are having, and discuss potential solutions to mitigate the pollution and its effects.

These are experiments students can use for Biology EE topics:

• Looking at how pollution impacts a certain type of animal or plant: This would involve checking out pollution levels in a specific place, then watching to see how it affects your chosen species.
• Understanding how certain genes affect a disease or characteristic: This would mean doing genetic tests to identify the genes involved, and potentially using genetic engineering techniques to change those genes and see what happens.
• Comparing how a mammal and a bird work: You’d do experiments to see how your chosen mammal and bird are similar or different. You could look at things like brain structure, behaviour, and thinking abilities.
• Exploring how climate change impacts a certain animal, plant, or ecosystem: This could involve experiments to see how changes in temperature, rain patterns, or CO2 levels affect your chosen species or ecosystem.
• Studying how people’s actions affect how a species evolves: This might mean looking at how things like habitat destruction, hunting, or pollution impact a species’ genetic diversity and population.
• Looking at how a certain plant works: You’d do experiments to see how the plant responds to things like light, temperature, or water.
• Studying how well a medicinal plant works: You’d do experiments to see how good the plant is at killing or slowing the growth of microbes, or reducing pain or inflammation.
• Comparing a certain animal in captivity and in the wild: You’d look at how being in captivity affects the animal’s body and how it works, and how it behaves.
• Seeing how an invasive species affects an ecosystem: You’d study how your chosen invasive species impacts the growth, reproduction, and health of native species.
• Studying how different fertilizers affect a plant: This could involve testing different types of fertilizers to see how they affect the plant’s growth rate, leaf size, and health.
• Looking at how certain species interact: You’d do experiments to understand the relationship between the species. This could involve seeing what happens when you remove one species, or how different environments affect the relationship.
• Studying how light affects a plant: This might mean doing experiments to see how different light conditions affect the plant’s growth, leaf size, and health.
• Looking at how temperature affects a microorganism: You’d do experiments to see how different temperatures impact the microorganism’s growth rate, metabolism, and health.
• Studying genetic diversity in a species: This could involve using genetic markers to identify genetic variations in the species, and then seeing how these variations affect the organism.
• Looking at how pH levels affect a plant: You’d do experiments to see how different pH levels impact the plant’s growth, leaf size, and health.
• Studying how people’s actions affect a species’ population: This might mean looking at how things like habitat destruction, hunting, or pollution impact the species’ population size, growth rate, and health.
• Looking at how soil types affect a plant: This could involve doing experiments to see how different types of soil affect the plant’s growth, leaf size, and health.
• Studying how pesticides affect a species: This might mean doing experiments to see how different pesticides impact the species’ growth, reproduction, and health.
• Looking at how water conditions affect a plant: You’d do experiments to see how different water conditions (like availability, salt levels, or temperature) affect the plant’s growth, leaf size, and health.
• Studying how ocean acidification affects a marine species: This could involve doing experiments to see how increasing acidity levels impact the species’ growth, reproduction, and health.

Additionally, in an essay on the comparative psychiatry of a specific mammal and bird, a student could research and compare the brain structures, behaviors, and cognitive abilities of the two species and discuss any similarities and differences found.

A student can ask for help from a writing service if they need assistance with their essay. This can bring several benefits to the student, such as:

• Professional guidance . Writing services often have experienced writers and editors who can provide guidance on the essay topic and structure, as well as help with research and editing.
• Improved quality . A writing service can help improve the overall quality of the essay, including grammar, punctuation, and formatting.
• Better grades . With the help of a writing service, a student’s essay is likely to be of higher quality, which can lead to better grades.
• Time-saving . A writing service can help save time as the student can focus on other responsibilities while the writing service works on the essay.
• Customization . Writing services can also provide a customized service that can be tailored to the student’s specific needs and requirements.
• Originality . Professional writers will provide original work that is free from plagiarism, which is important in academic writing.

It is important to note, however, that a student should always ensure that the writing service they use is reputable and that they review and understand the work they receive before submitting it as their own.

Luke MacQuoid has extensive experience teaching English as a foreign language in Japan, having worked with students of all ages for over 12 years. Currently, he is teaching at the tertiary level. Luke holds a BA from the University of Sussex and an MA in TESOL from Lancaster University, both located in England. As well to his work as an IB Examiner and Master Tutor, Luke also enjoys sharing his experiences and insights with others through writing articles for various websites, including extendedessaywriters.com blog

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• Cancer Control
• v.28; Jan-Dec 2021

Cancer Biology, Epidemiology, and Treatment in the 21st Century: Current Status and Future Challenges From a Biomedical Perspective

Patricia piña-sánchez.

1 Oncology Research Unit, Oncology Hospital, Mexican Institute of Social Security, Mexico

Antonieta Chávez-González

Martha ruiz-tachiquín, eduardo vadillo, alberto monroy-garcía, juan josé montesinos, rocío grajales.

2 Department of Medical Oncology, Oncology Hospital, Mexican Institute of Social Security, Mexico

Marcos Gutiérrez de la Barrera

3 Clinical Research Division, Oncology Hospital, Mexican Institute of Social Security, Mexico

Hector Mayani

Since the second half of the 20th century, our knowledge about the biology of cancer has made extraordinary progress. Today, we understand cancer at the genomic and epigenomic levels, and we have identified the cell that starts neoplastic transformation and characterized the mechanisms for the invasion of other tissues. This knowledge has allowed novel drugs to be designed that act on specific molecular targets, the immune system to be trained and manipulated to increase its efficiency, and ever more effective therapeutic strategies to be developed. Nevertheless, we are still far from winning the war against cancer, and thus biomedical research in oncology must continue to be a global priority. Likewise, there is a need to reduce unequal access to medical services and improve prevention programs, especially in countries with a low human development index.

Introduction

During the last one hundred years, our understanding of the biology of cancer increased in an extraordinary way. 1 - 4 Such a progress has been particularly prompted during the last few decades because of technological and conceptual progress in a variety of fields, including massive next-generation sequencing, inclusion of “omic” sciences, high-resolution microscopy, molecular immunology, flow cytometry, analysis and sequencing of individual cells, new cell culture techniques, and the development of animal models, among others. Nevertheless, there are many questions yet to be answered and many problems to be solved regarding this disease. As a consequence, oncological research must be considered imperative.

Currently, cancer is one of the illnesses that causes more deaths worldwide. 5 According to data reported in 2020 by the World Health Organization (WHO), cancer is the second cause of death throughout the world, with 10 million deaths. 6 Clearly, cancer is still a leading problem worldwide. With this in mind, the objective of this article is to present a multidisciplinary and comprehensive overview of the disease. We will begin by analyzing cancer as a process, focusing on the current state of our knowledge on 4 specific aspects of its biology. Then, we will look at cancer as a global health problem, considering some epidemiological aspects, and discussing treatment, with a special focus on novel therapies. Finally, we present our vision on some of the challenges and perspectives of cancer in the 21 st century.

The Biology of Cancer

Cancer is a disease that begins with genetic and epigenetic alterations occurring in specific cells, some of which can spread and migrate to other tissues. 4 Although the biological processes affected in carcinogenesis and the evolution of neoplasms are many and widely different, we will focus on 4 aspects that are particularly relevant in tumor biology: genomic and epigenomic alterations that lead to cell transformation, the cells where these changes occur, and the processes of invasion and metastasis that, to an important degree, determine tumor aggressiveness.

Cancer Genomics

The genomics of cancer can be defined as the study of the complete sequence of DNA and its expression in tumor cells. Evidently, this study only becomes meaningful when compared to normal cells. The sequencing of the human genome, completed in 2003, was not only groundbreaking with respect to the knowledge of our gene pool, but also changed the way we study cancer. In the post-genomic era, various worldwide endeavors, such as the Human Cancer Genome Project , the Cancer Genome ATLAS (TCGA), the International Cancer Genome Consortium, and the Pan-Cancer Analysis Working Group (PCAWG), have contributed to the characterization of thousands of primary tumors from different neoplasias, generating more than 2.5 petabytes (10 15 ) of genomic, epigenomic, and proteomic information. This has led to the building of databases and analytical tools that are available for the study of cancer from an “omic” perspective, 7 , 8 and it has helped to modify classification and treatment of various neoplasms.

Studies in the past decade, including the work by the PCAWG, have shown that cancer generally begins with a small number of driving mutations (4 or 5 mutations) in particular genes, including oncogenes and tumor-suppressor genes. Mutations in TP53, a tumor-suppressor gene, for example, are found in more than half of all cancer types as an early event, and they are a hallmark of precancerous lesions. 9 - 12 From that point on, the evolution of tumors may take decades, throughout which the mutational spectrum of tumor cells changes significantly. Mutational analysis of more than 19 000 exomes revealed a collection of genomic signatures, some associated with defects in the mechanism of DNA repair. These studies also revealed the importance of alterations in non-coding regions of DNA. Thus, for example, it has been observed that various pathways of cell proliferation and chromatin remodeling are altered by mutations in coding regions, while pathways, such as WNT and NOTCH, can be disrupted by coding and non-coding mutations. To the present date, 19 955 genes that codify for proteins and 25 511 genes for non-coding RNAs have been identified ( https://www.gencodegenes.org/human/stats.html ). Based on this genomic catalogue, the COSMIC (Catalogue Of Somatic Mutations In Cancer) repository, the most robust database to date, has registered 37 288 077 coding mutations, 19 396 fusions, 1 207 190 copy number variants, and 15 642 672 non-coding variants reported up to August 2020 (v92) ( https://cosmic-blog.sanger.ac.uk/cosmic-release-v92/ ).

The genomic approach has accelerated the development of new cancer drugs. Indeed, two of the most relevant initiatives in recent years are ATOM (Accelerating Therapeutics for Opportunities in Medicine), which groups industry, government and academia, with the objective of accelerating the identification of drugs, 13 and the Connectivity Map (CMAP), a collection of transcriptional data obtained from cell lines treated with drugs for the discovery of functional connections between genes, diseases, and drugs. The CMAP 1.0 covered 1300 small molecules and more than 6000 signatures; meanwhile, the CMAP 2.0 with L1000 assay profiled more than 1.3 million samples and approximately 400 000 signatures. 14

The genomic study of tumors has had 2 fundamental contributions. On the one hand, it has allowed the confirmation and expansion of the concept of intratumor heterogeneity 15 , 16 ; and on the other, it has given rise to new classification systems for cancer. Based on the molecular classification developed by expression profiles, together with mutational and epigenomic profiles, a variety of molecular signatures have been identified, leading to the production of various commercial multigene panels. In breast cancer, for example, different panels have been developed, such as Pam50/Prosigna , Blue Print , OncotypeDX , MammaPrint , Prosigna , Endopredict , Breast Cancer Index , Mammostrat, and IHC4 . 17

Currently, the genomic/molecular study of cancer is more closely integrated with clinical practice, from the classification of neoplasms, as in tumors of the nervous system, 18 to its use in prediction, as in breast cancer. 17 Improvement in molecular methods and techniques has allowed the use of smaller amounts of biological material, as well as paraffin-embedded samples for genomic studies, both of which provide a wealth of information. 19 In addition, non-invasive methods, such as liquid biopsies, represent a great opportunity not only for the diagnosis of cancer, but also for follow-up, especially for unresectable tumors. 20

Research for the production of genomic information on cancer is presently dominated by several consortia, which has allowed the generation of a great quantity of data. However, most of these consortia and studies are performed in countries with a high human development index (HDI), and countries with a low HDI are not well represented in these large genomic studies. This is why initiatives such as Human Heredity and Health in Africa (H3Africa) for genomic research in Africa are essential. 21 Generation of new information and technological developments, such as third-generation sequencing, will undoubtedly continue to move forward in a multidisciplinary and complex systems context. However, the existing disparities in access to genomic tools for diagnosis, prognosis, and treatment of cancer will continue to be a pressing challenge at regional and social levels.

Cancer Epigenetics

Epigenetics studies the molecular mechanisms that produce hereditable changes in gene expression, without causing alterations in the DNA sequence. Epigenetic events are of 3 types: methylation of DNA and RNA, histone modification (acetylation, methylation, and phosphorylation), and the expression of non-coding RNA. Epigenetic aberrations can drive carcinogenesis when they alter chromosome conformation and the access to transcriptional machinery and to various regulatory elements (promoters, enhancers, and anchors for interaction with chromatin, for example). These changes may activate oncogenesis and silence tumor-suppressor mechanisms when they modulate coding and non-coding sequences (such as micro-RNAs and long-RNAs). This can then lead to uncontrolled growth, as well as the invasion and metastasis of cancer cells.

While genetic mutations are stable and irreversible, epigenetic alterations are dynamic and reversible; that is, there are several epigenomes, determined by space and time, which cause heterogeneity of the “epigenetic status” of tumors during their development and make them susceptible to environmental stimuli or chemotherapeutic treatment. 22 Epigenomic variability creates differences between cells, and this creates the need to analyze cells at the individual level. In the past, epigenetic analyses measured “average states” of cell populations. These studies revealed general mechanisms, such as the role of epigenetic marks on active or repressed transcriptional states, and established maps of epigenetic composition in a variety of cell types in normal and cancerous tissue. However, these approaches are difficult to use to examine events occurring in heterogeneous cell populations or in uncommon cell types. This has led to the development of new techniques that permit marking of a sequence on the epigenome and improvement in the recovery yield of epigenetic material from individual cells. This has helped to determine changes in DNA, RNA, and histones, chromatin accessibility, and chromosome conformation in a variety of neoplasms. 23 , 24

In cancer, DNA hypomethylation occurs on a global scale, while hypermethylation occurs in specific genomic loci, associated with abnormal nucleosome positioning and chromatin modifications. This information has allowed epigenomic profiles to be established in different types of neoplasms. In turn, these profiles have served as the basis to identify new neoplasm subgroups. For example, in triple negative breast cancer (TNBC), 25 and in hepatocellular carcinoma, 26 DNA methylation profiles have helped to the identification of distinct subgroups with clinical relevance. Epigenetic approaches have also helped to the development of prognostic tests to assess the sensitivity of cancer cells to specific drugs. 27

Epigenetic traits could be used to characterize intratumoral heterogeneity and determine the relevance of such a heterogeneity in clonal evolution and sensitivity to drugs. However, it is clear that heterogeneity is not only determined by genetic and epigenetic diversity resulting from clonal evolution of tumor cells, but also by the various cell populations that form the tumor microenvironment (TME). 28 Consequently, the epigenome of cancer cells is continually remodeled throughout tumorigenesis, during resistance to the activity of drugs, and in metastasis. 29 This makes therapeutic action based on epigenomic profiles difficult, although significant advances in this area have been reported. 30

During carcinogenesis and tumor progression, epigenetic modifications are categorized by their mechanisms of regulation ( Figure 1A ) and the various levels of structural complexity ( Figure 1B ). In addition, the epigenome can be modified by environmental stimuli, stochastic events, and genetic variations that impact the phenotype ( Figure 1C ). 31 , 32 The molecules that take part in these mechanisms/events/variations are therapeutic targets of interest with potential impact on clinical practice. There are studies on a wide variety of epidrugs, either alone or in combination, which improve antitumor efficacy. 33 However, the problems with these drugs must not be underestimated. For a considerable number of epigenetic compounds still being under study, the main challenge is to translate in vitro efficacy of nanomolar (nM) concentrations into well-tolerated and efficient clinical use. 34 The mechanisms of action of epidrugs may not be sufficiently controlled and could lead to diversion of the therapeutic target. 35 It is known that certain epidrugs, such as valproic acid, produce unwanted epigenetic changes 36 ; thus the need for a well-established safety profile before these drugs can be used in clinical therapy. Finally, resistance to certain epidrugs is another relevant problem. 37 , 38

Epigenetics of cancer. (A) Molecular mechanisms. (B) Structural hierarchy of epigenomics. (C) Factors affecting the epigenome. Modified from Refs. 31 and 32 .

As we learn about the epigenome of specific cell populations in cancer patients, a door opens to the evaluation of sensitivity tests and the search for new molecular markers for detection, prognosis, follow-up, and/or response to treatment at various levels of molecular regulation. Likewise, the horizon expands for therapeutic alternatives in oncology with the use of epidrugs, such as pharmacoepigenomic modulators for genes and key pathways, including methylation of promoters and regulation of micro-RNAs involved in chemoresponse and immune response in cancer. 39 There is no doubt that integrated approaches identifying stable pharmagenomic and epigenomic patterns and their relation with expression profiles and genetic functions will be more and more valuable in our fight against cancer.

Cancer Stem Cells

Tumors consist of different populations of neoplastic cells and a variety of elements that form part of the TME, including stromal cells and molecules of the extracellular matrix. 40 Such intratumoral heterogeneity becomes even more complex during clonal variation of transformed cells, as well as influence the elements of the TME have on these cells throughout specific times and places. 41 To explain the origin of cancer cell heterogeneity, 2 models have been put forward. The first proposes that mutations occur at random during development of the tumor in individual neoplastic cells, and this promotes the production of various tumor populations, which acquire specific growth and survival traits that lead them to evolve according to intratumor mechanisms of natural selection. 42 The second model proposes that each tumor begins as a single cell that possess 2 functional properties: it can self-renew and it can produce several types of terminal cells. As these 2 properties are characteristics of somatic stem cells, 43 the cells have been called cancer stem cells (CSCs). 44 According to this model, tumors must have a hierarchical organization, where self-renewing stem cells produce highly proliferating progenitor cells, unable to self-renew but with a high proliferation potential. The latter, in turn, give rise to terminal cells. 45 Current evidence indicates that both models may coexist in tumor progression. In agreement with this idea, new subclones could be produced as a result of a lack of genetic stability and mutational changes, in addition to the heterogeneity derived from the initial CSC and its descendants. Thus, in each tumor, a set of neoplastic cells with different genetic and epigenetic traits may be found, which would provide different phenotypic properties. 46

The CSC concept was originally presented in a model of acute myeloid leukemia. 47 The presence of CSCs was later proved in chronic myeloid leukemia, breast cancer, tumors of the central nervous system, lung cancer, colon cancer, liver cancer, prostate cancer, pancreatic cancer, melanoma, and cancer of the head and neck, amongst others. In all of these cases, detection of CSCs was based on separation of several cell populations according to expression of specific surface markers, such as CD133, CD44, CD24, CD117, and CD15. 48 It is noteworthy that in some solid tumors, and even in some hematopoietic ones, a combination of specific markers that allow the isolation of CSCs has not been found. Interestingly, in such tumors, a high percentage of cells with the capacity to start secondary tumors has been observed; thus, the terms Tumor Initiating Cells (TIC) or Leukemia Initiating Cells (LIC) have been adopted. 46

A relevant aspect of the biology of CSCs is that, just like normal stem cells, they can self-renew. Such self-renewal guarantees the maintenance or expansion of the tumor stem cell population. Another trait CSCs share with normal stem cells is their quiescence, first described in chronic myeloid leukemia. 49 The persistence of quiescent CSCs in solid tumors has been recently described in colorectal cancer, where quiescent clones can become dominant after therapy with oxaliplatin. 50 In non-hierarchical tumors, such as melanoma, the existence of slow-cycling cells that are resistant to antimitogenic agents has also been proved. 51 Such experimental evidence supports the idea that quiescent CSCs or TICs are responsible for both tumor resistance to antineoplastic drugs and clinical relapse after initial therapeutic success.

In addition to quiescence, CSCs use other mechanisms to resist the action of chemotherapeutic drugs. One of these is their increased numbers: upon diagnosis, a high number of CSCs are observed in most analyzed tumors, making treatment unable to destroy all of them. On the other hand, CSCs have a high number of molecular pumps that expulse drugs, as well as high numbers of antiapoptotic molecules. In addition, they have very efficient mechanisms to repair DNA damage. In general, these cells show changes in a variety of signaling pathways involved in proliferation, survival, differentiation, and self-renewal. It is worth highlighting that in recent years, many of these pathways have become potential therapeutic targets in the elimination of CSCs. 52 Another aspect that is highly relevant in understanding the biological behavior of CSCs is that they require a specific site for their development within the tissue where they are found that can provide whatever is needed for their survival and growth. These sites, known as niches, are made of various cells, both tumor and non-tumor, as well as a variety of non-cellular elements (extracellular matrix [ECM], soluble cytokines, ion concentration gradients, etc.), capable of regulating the physiology of CSCs in order to promote their expansion, the invasion of adjacent tissues, and metastasis. 53

It is important to consider that although a large number of surface markers have been identified that allow us to enrich and prospectively follow tumor stem cell populations, to this day there is no combination of markers that allows us to find these populations in all tumors, and it is yet unclear if all tumors present them. In this regard, it is necessary to develop new purification strategies based on the gene expression profiles of these cells, so that tumor heterogeneity is taken into account, as it is evident that a tumor can include multiple clones of CSCs that, in spite of being functional, are genetically different, and that these clones can vary throughout space (occupying different microenvironments and niches) and time (during the progression of a range of tumor stages). Such strategies, in addition to new in vitro and in vivo assays, will allow the development of new and improved CSC elimination strategies. This will certainly have an impact on the development of more efficient therapeutic alternatives.

Invasion and Metastasis

Nearly 90% of the mortality associated with cancer is related to metastasis. 54 This consists of a cascade of events ( Figure 2 ) that begins with the local invasion of a tumor into surrounding tissues, followed by intravasation of tumor cells into the blood stream or lymphatic circulation. Extravasation of neoplastic cells in areas distant from the primary tumor then leads to the formation of one or more micrometastatic lesions which subsequently proliferate to form clinically detectable lesions. 4 The cells that are able to produce metastasis must acquire migratory characteristics, which occur by a process known as epithelial–mesenchymal transition (EMT), that is, the partial loss of epithelial characteristics and the acquirement of mesenchymal traits. 55

Invasion and metastasis cascade. Invasion and metastasis can occur early or late during tumor progression. In either case, invasion to adjacent tissues is driven by stem-like cells (cancer stem cells) that acquire the epithelial–mesenchymal transition (EMT) (1). Once they reach sites adjacent to blood vessels, tumor cells (individually or in clusters) enter the blood (2). Tumor cells in circulation can adhere to endothelium and extravasation takes place (3). Other mechanisms alternative to extravasation can exist, such as angiopelosis, in which clusters of tumor cells are internalized by the endothelium. Furthermore, at certain sites, tumor cells can obstruct microvasculature and initiate a metastatic lesion right there. Sometimes, a tumor cells that has just exit circulation goes into an MET in order to become quiescent (4). Inflammatory signals can activate quiescent metastatic cells that will proliferate and generate a clinically detectable lesion (5).

Although several of the factors involved in this process are currently known, many issues are still unsolved. For instance, it has not yet been possible to monitor in vivo the specific moment when it occurs 54 ; the microenvironmental factors of the primary tumor that promote such a transition are not known with precision; and the exact moment during tumor evolution in which one cell or a cluster of cells begin to migrate to distant areas, is also unknown. The wide range of possibilities offered by intra- and inter-tumoral heterogeneity 56 stands in the way of suggesting a generalized strategy that could resolve this complication.

It was previously believed that metastasis was only produced in late stages of tumor progression; however, recent studies indicate that EMT and metastasis can occur during the early course of the disease. In pancreatic cancer, for example, cells going through EMT are able to colonize and form metastatic lesions in the liver in the first stages of the disease. 52 , 57 Metastatic cell clusters circulating in peripheral blood (PB) are prone to generate a metastatic site, compared to individual tumor cells. 58 , 59 In this regard, novel strategies, such as the use of micro-RNAs, are being assessed in order to diminish induction of EMT. 60 It must be mentioned, however, that the metastatic process seems to be even more complex, with alternative pathways that do not involve EMT. 61 , 62

A crucial stage in the process of metastasis is the intravasation of tumor cells (alone or in clusters) towards the blood stream and/or lymphatic circulation. 63 These mechanisms are also under intensive research because blocking them could allow the control of spreading of the primary tumor. In PB or lymphatic circulation, tumor cells travel to distant parts for the potential formation of a metastatic lesion. During their journey, these cells must stand the pressure of blood flow and escape interaction with natural killer (NK) cells . 64 To avoid them, tumor cells often cover themselves with thrombocytes and also produce factors such as VEGF, angiopoietin-2, angiopoietin-4, and CCL2 that are involved in the induction of vascular permeability. 54 , 65 Neutrophils also contribute to lung metastasis in the bloodstream by secreting IL-1β and metalloproteases to facilitate extravasation of tumor cells. 64

The next step in the process of metastasis is extravasation, for which tumor cells, alone or in clusters, can use various mechanisms, including a recently described process known as angiopellosis that involves restructuring the endothelial barrier to internalize one or several cells into a tissue. 66 The study of leukocyte extravasation has contributed to a more detailed knowledge of this process, in such a way that some of the proposed strategies to avoid extravasation include the use of integrin inhibitors, molecules that are vital for rolling, adhesion, and extravasation of tumor cells. 67 , 68 Another strategy that has therapeutic potential is the use of antibodies that strengthen vascular integrity to obstruct transendothelial migration of tumor cells and aid in their destruction in PB. 69

Following extravasation, tumor cells can return to an epithelial phenotype, a process known as mesenchymal–epithelial transition and may remain inactive for several years. They do this by competing for specialized niches, like those in the bone marrow, brain, and intestinal mucosa, which provide signals through the Notch and Wnt pathways. 70 Through the action of the Wnt pathway, tumor cells enter a slow state of the cell cycle and induce the expression of molecules that inhibit the cytotoxic function of NK cells. 71 The extravasated tumor cell that is in a quiescent state must comply with 2 traits typical of stem cells: they must have the capacity to self-renew and to generate all of the cells that form the secondary tumor.

There are still several questions regarding the metastatic process. One of the persisting debates at present is if EMT is essential for metastasis or if it plays a more important role in chemoresistance. 61 , 62 It is equally important to know if there is a pattern in each tumor for the production of cells with the capacity to carry out EMT. In order to control metastasis, it is fundamental to know what triggers acquisition of the migratory phenotype and the intrinsic factors determining this transition. Furthermore, it is essential to know if mutations associated with the primary tumor or the variety of epigenetic changes are involved in this process. 55 It is clear that metastatic cells have affinity for certain tissues, depending on the nature of the primary tumor (seed and soil hypothesis). This may be caused by factors such as the location and the direction of the bloodstream or lymphatic fluid, but also by conditioning of premetastatic niches at a distance (due to the large number of soluble factors secreted by the tumor and the recruitment of cells of the immune system to those sites). 72 We have yet to identify and characterize all of the elements that participate in this process. Deciphering them will be of upmost importance from a therapeutic point of view.

Epidemiology of Cancer

Cancer is the second cause of death worldwide; today one of every 6 deaths is due to a type of cancer. According to the International Agency for Research on Cancer (IARC), in 2020 there were approximately 19.3 million new cases of cancer, and 10 million deaths by this disease, 6 while 23.8 million cases and 13.0 million deaths are projected to occur by 2030. 73 In this regard, it is clear the increasing role that environmental factors—including environmental pollutants and processed food—play as cancer inducers and promoters. 74 The types of cancer that produce the greatest numbers of cases and deaths worldwide are indicated in Table 1 . 6

Total Numbers of Cancer Cases and Deaths Worldwide in 2020 by Cancer Type (According to the Global Cancer Observatory, IARC).

Data presented on this table were obtained from Ref. 6.

As shown in Figure 3 , lung, breast, prostate, and colorectal cancer are the most common throughout the world, and they are mostly concentrated in countries of high to very high human development index (HDI). Although breast, prostate, and colorectal cancer have a high incidence, the number of deaths they cause is proportionally low, mostly reflecting the great progress made in their control. However, these data also reveal the types of cancer that require further effort in prevention, precise early detection avoiding overdiagnosis, and efficient treatment. This is the case of liver, lung, esophageal, and pancreatic cancer, where the difference between the number of cases and deaths is smaller ( Figure 3B ). Social and economic transition in several countries has had an impact on reducing the incidence of neoplasms associated with infection and simultaneously produced an increase in the types related to reproductive, dietary, and hormonal factors. 75

Incidence and mortality for some types of cancer in the world. (A) Estimated number of cases and deaths in 2020 for the most frequent cancer types worldwide. (B) Incidence and mortality rates, normalized according to age, for the most frequent cancer types in countries with very high/& high (VH&H; blue) and/low and middle (L&M; red) Human Development Index (HDI). Data include both genders and all ages. Data according to https://gco.iarc.fr/today , as of June 10, 2021.

In the past 3 decades, cancer mortality rates have fallen in high HDI countries, with the exception of pancreatic cancer, and lung cancer in women. Nevertheless, changes in the incidence of cancer do not show the same consistency, possibly due to variables such as the possibility of early detection, exposure to risk factors, or genetic predisposition. 76 , 77 Countries such as Australia, Canada, Denmark, Ireland, New Zealand, Norway, and the United Kingdom have reported a reduction in incidence and mortality in cancer of the stomach, colon, lung, and ovary, as well as an increase in survival. 78 Changes in modifiable risk factors, such as the use of tobacco, have played an important role in prevention. In this respect, it has been estimated that decline in tobacco use can explain between 35% and 45% of the reduction in cancer mortality rates, 79 while the fall in incidence and mortality due to stomach cancer can be attributed partly to the control of Helicobacter pylori infection. 80 Another key factor in the fall of mortality rates in developed countries has been an increase in early detection as a result of screening programs, as in breast and prostate cancer, which have had their mortality rates decreased dramatically in spite of an increase in their incidence. 76

Another important improvement observed in recent decades is the increase in survival rates, particularly in high HDI countries. In the USA, for example, survival rates for patients with prostate cancer at 5 years after initial diagnosis was 28% during 1947–1951; 69% during 1975–1977, and 100% during 2003–2009. Something similar occurred with breast cancer, with a 5-year survival rate of 54% in 1947–1951, 75% in 1975–1977, and 90% in 2003–2009. 81 In the CONCORD 3 version, age-standardize 5-year survival for patients with breast cancer in the USA during 2010–2014 was 90%, and 97% for prostate cancer patients. 82 Importantly, even among high HDI countries, significant differences have been identified in survival rates, being stage of disease at diagnosis, time for access to effective treatment, and comorbidities, the main factors influencing survival in these nations. 78 Unfortunately, survival rates in low HDI countries are significantly lower due to several factors, including lack of information, deficient screening and early detection programs, limited access to treatment, and suboptimal cancer registration. 82 It should be noted that in countries with low to middle HDI, neoplasms with the greatest incidence are those affecting women (breast and cervical cancer), which reflects not only a problem with access to health services, but also a serious inequality issue that involves social, cultural, and even religious obstacles. 83

Up to 42% of incident cases and 47% of deaths by cancer in the USA are due to potentially modifiable risk factors such as use of tobacco, physical activity, diet, and infection. 84 It has been calculated that 2.4 million deaths by cancer, mostly of the lung, can be attributed to tobacco. 73 In 2020, the incidence rate of lung cancer in Western Africa was 2.2, whereas in Polynesia and Eastern Asia was 37.3 and 34.4, respectively. 6 In contrast, the global burden of cancer associated with infection was 15.4%, but in Sub-Saharan Africa it was 30%. 85 Likewise, the incidence of cervical cancer in Eastern Africa was 40.1, in contrast with the USA and Canada that have a rate of 6.2. This makes it clear that one of the challenges we face is the reduction of the risk factors that are potentially modifiable and associated with specific types of cancer.

Improvement of survival rates and its disparities worldwide are also important challenges. Five-year survival for breast cancer—diagnosed during 2010-2014— in the USA, for example, was 90%, whereas in countries like South Africa it was 40%. 82 Childhood leukemia in the USA and several European countries shows a 5-year survival of 90%, while in Latin-American countries it is 50–76%. 86 Interestingly, there are neoplasms, such as pancreatic cancer, for which there has been no significant increase in survival, which remains low (5–15%) both in developed and developing countries. 82

Although data reported on global incidence and mortality gives a general overview on the epidemiology of cancer, it is important to note that there are great differences in coverage of cancer registries worldwide. To date, only 1 out of every 3 countries reports high quality data on the incidence of cancer. 87 For the past 50 years, the IARC has supported population-based cancer registries; however, more than one-third of the countries belonging to the WHO, mainly countries of low and middle income (LMIC), have no data on more than half of the 18 indicators of sustainable development goals. 88 High quality cancer registries only cover 4% of the population in Africa, 8% in Asia, and 7% in Latin America, contrasting with 83% in the USA and Canada, and 33% in Europe. 89 In response to this situation, the Global Initiative for Cancer Registry Development was created in 2012 to generate improved infrastructure to permit greater coverage and better quality registries, especially in countries with low and middle HDI. 88 It is expected that initiatives of this sort in the coming years will allow more and better information to guide strategies for the control of cancer worldwide, especially in developing regions. This will enable survival to be measured over longer periods of time (10, 15, or 20 years), as an effective measure in the control of cancer. The WHO has established as a target for 2025 to reduce deaths by cancer and other non-transmissible diseases by 25% in the population between the ages of 30–69; such an effort requires not only effective prevention measures to reduce incidence, but also more efficient health systems to diminish mortality and increase survival. At the moment, it is an even greater challenge because of the effects of the COVID-19 pandemic which has negatively impacted cancer prevention and health services. 90

Oncologic Treatments

A general perspective.

At the beginning of the 20th century, cancer treatment, specifically treatment of solid tumors, was based fundamentally on surgical resection of tumors, which together with other methods for local control, such as cauterization, had been used since ancient times. 91 At that time, there was an ongoing burst of clinical observations along with interventions sustained on fundamental knowledge about physics, chemistry, and biology. In the final years of the 19 th century and the first half of the 20th, these technological developments gave rise to radiotherapy, hormone therapy, and chemotherapy. 92 - 94 Simultaneously, immunotherapy was also developed, although usually on a smaller scale, in light of the overwhelming progress of chemotherapy and radiotherapy. 95

Thus began the development and expansion of disciplines based on these approaches (surgery, radiotherapy, chemotherapy, hormone therapy, and immunotherapy), with their application evolving ever more rapidly up to their current uses. Today, there is a wide range of therapeutic tools for the care of cancer patients. These include elements that emerged empirically, arising from observations of their effects in various medical fields, as well as drugs that were designed to block processes and pathways that form part of the physiopathology of one or more neoplasms according to knowledge of specific molecular alterations. A classic example of the first sort of tool is mustard gas, originally used as a weapon in war, 96 but when applied for medical purposes, marked the beginning of the use of chemicals in the treatment of malignant neoplasms, that is, chemotherapy. 94 A clear example of the second case is imatinib, designed specifically to selectively inhibit a molecular alteration in chronic myeloid leukemia: the Bcr-Abl oncoprotein. 97

It is on this foundation that today the 5 areas mentioned previously coexist and complement one another. The general framework that motivates this amalgam and guides its development is precision medicine, founded on the interaction of basic and clinical science. In the forecasts for development in each of these fields, surgery is expected to continue to be the fundamental approach for primary tumors in the foreseeable future, as well as when neoplastic disease in the patient is limited, or can be limited by applying systemic or regional elements, before and/or after surgical resection, and it can be reasonably anticipated for the patient to have a significant period free from disease or even to be cured. With regards to technology, intensive exploration of robotic surgery is contemplated. 98

The technological possibilities for radiotherapy have progressed in such a way that it is now possible to radiate neoplastic tissue with an extraordinary level of precision, and therefore avoid damage to healthy tissue. 99 This allows administration of large doses of ionizing radiation in one or a few fractions, what is known as “radiosurgery.” The greatest challenges to the efficacy of this approach are related to radio-resistance in certain neoplasms. Most efforts regarding research in this field are concentrated on understanding the underlying biological mechanisms of the phenomenon and their potential control through radiosensitizers. 100

“Traditional” chemotherapy, based on the use of compounds obtained from plants and other natural products, acting in a non-specific manner on both neoplastic and healthy tissues with a high proliferation rate, continues to prevail. 101 The family of chemotherapeutic drugs currently includes alkylating agents, antimetabolites, anti-topoisomerase agents, and anti-microtubules. Within the pharmacologic perspective, the objective is to attain a high concentration or activity of such molecules in specific tissues while avoiding their accumulation in others, in order to achieve an increase in effectiveness and a reduction in toxicity. This has been possible with the use of viral vectors, for example, that are able to limit their replication in neoplastic tissues, and activate prodrugs of normally nonspecific agents, like cyclophosphamide, exclusively in those specific areas. 102 More broadly, chemotherapy also includes a subgroup of substances, known as molecular targeted therapy, that affect processes in a more direct and specific manner, which will be mentioned later.

There is no doubt that immunotherapy—to be explored next—is one of the therapeutic fields where development has been greatest in recent decades and one that has produced enormous expectation in cancer treatment. 103 Likewise, cell therapy, based on the use of immune cells or stem cells, has come to complement the oncologic therapeutic arsenal. 43 Each and every one of the therapeutic fields that have arisen in oncology to this day continue to prevail and evolve. Interestingly, the foreseeable future for the development of cancer treatment contemplates these approaches in a joint and complementary manner, within the general framework of precision medicine, 104 and sustained by knowledge of the biological mechanisms involved in the appearance and progression of neoplasms. 105 , 106

Immunotherapy

Stimulating the immune system to treat cancer patients has been a historical objective in the field of oncology. Since the early work of William Coley 107 to the achievements reached at the end of the 20 th century, scientific findings and technological developments paved the way to searching for new immunotherapeutic strategies. Recombinant DNA technology allowed the synthesis of cytokines, such as interferon-alpha (IFN-α) and interleukin 2 (IL-2), which were authorized by the US Food and Drug Administration (FDA) for the treatment of hairy cell leukemia in 1986, 108 as well as kidney cancer and metastatic melanoma in 1992 and 1998, respectively. 109

The first therapeutic vaccine against cancer, based on the use of autologous dendritic cells (DCs), was approved by the FDA against prostate cancer in 2010. However, progress in the field of immunotherapy against cancer was stalled in the first decade of the present century, mostly due to failure of several vaccines in clinical trials. In many cases, application of these vaccines was detained by the complexity and cost involved in their production. Nevertheless, with the coming of the concept of immune checkpoint control, and the demonstration of the relevance of molecules such as cytotoxic T-lymphocyte antigen 4 (CTLA-4), and programmed cell death molecule-1 (PD-1), immunotherapy against cancer recovered its global relevance. In 2011, the monoclonal antibody (mAb) ipilimumab, specific to the CTLA-4 molecule, was the first checkpoint inhibitor (CPI) approved for the treatment of advanced melanoma. 110 Later, inhibitory mAbs for PD-1, or for the PD-1 ligand (PD-L1), 111 as well as the production of T cells with chimeric receptors for antigen recognition (CAR-T), 112 which have been approved to treat various types of cancer, including melanoma, non-small cell lung cancer (NSCLC), head and neck cancer, bladder cancer, renal cell carcinoma (RCC), and hepatocellular carcinoma, among others, have changed the paradigm of cancer treatment.

In spite of the current use of anti-CTLA-4 and anti-PD-L1 mAbs, only a subgroup of patients has responded favorably to these CPIs, and the number of patients achieving clinical benefit is still small. It has been estimated that more than 70% of patients with solid tumors do not respond to CPI immunotherapy because either they show primary resistance, or after responding favorably, develop resistance to treatment. 113 In this regard, it is important to mention that in recent years very important steps have been taken to identify the intrinsic and extrinsic mechanisms that mediate resistance to CPI immunotherapy. 114 Intrinsic mechanisms include changes in the antitumor immune response pathways, such as faulty processing and presentation of antigens by APCs, activation of T cells for tumor cell destruction, and changes in tumor cells that lead to an immunosuppressive TME. Extrinsic factors include the presence of immunosuppressive cells in the local TME, such as regulatory T cells, myeloid-derived suppressor cells (MDSC), mesenchymal stem/stromal cells (MSCs), and type 2 macrophages (M2), in addition to immunosuppressive cytokines.

On the other hand, classification of solid tumors as “hot,” “cold,” or “excluded,” depending on T cell infiltrates and the contact of such infiltrates with tumor cells, as well as those that present high tumor mutation burden (TMB), have redirected immunotherapy towards 3 main strategies 115 ( Table 2 ): (1) Making T-cell antitumor response more effective, using checkpoint inhibitors complementary to anti-CTLA-4 and anti-PD-L1, such as LAG3, Tim-3, and TIGT, as well as using CAR-T cells against tumor antigens. (2) Activating tumor-associated myeloid cells including monocytes, granulocytes, macrophages, and DC lineages, found at several frequencies within human solid tumors. (3) Regulating the biochemical pathways in TME that produce high concentrations of immunosuppressive molecules, such as kynurenine, a product of tryptophan metabolism, through the activity of indoleamine 2,3 dioxygenase; or adenosine, a product of ATP hydrolysis by the activity of the enzyme 5’nucleotidase (CD73). 116

Current Strategies to Stimulate the Immune Response for Antitumor Immunotherapy.

Abbreviations: TME, tumor microenvironment; IL, interleukin; TNF, Tumor Necrosis Factor; TNFR, TNF-receptor; CD137, receptor–co-stimulator of the TNFR family; OX40, member number 4 of the TNFR superfamily; CD27/CD70, member of the TNFR superfamily; CD40/CD40L, antigen-presenting cells (APC) co-stimulator and its ligand; GM-CSF, granulocyte-macrophage colony-stimulating factor; IFN, interferon; STING, IFN genes-stimulator; RIG-I, retinoic acid inducible gene-I; MDA5, melanoma differentiation-associated protein 5; CDN, cyclic dinucleotide; ATP, adenosine triphosphate; HMGB1, high mobility group B1 protein; TLR, Toll-like receptor; HVEM, Herpes virus entry mediator; GITR, glucocorticoid-induced TNFR family-related gene; CTLA4, cytotoxic T lymphocyte antigen 4; PD-L1, programmed death ligand-1; TIGIT, T-cell immunoreceptor with immunoglobulin and tyrosine-based inhibition motives; CSF1/CSF1R, colony-stimulating factor-1 and its receptor; CCR2, Type 2 chemokine receptor; PI3Kγ, Phosphoinositide 3-Kinase γ; CXCL/CCL, chemokine ligands; LFA1, lymphocyte function-associated antigen 1; ICAM1, intercellular adhesion molecule 1; VEGF, vascular endothelial growth factor; IDO, indolamine 2,3-dioxigenase; TGF, transforming growth factor; LAG-3, lymphocyte-activation gene 3 protein; TIM-3, T-cell immunoglobulin and mucin-domain containing-3; CD73, 5´nucleotidase; ARs, adenosine receptors; Selectins, cell adhesion molecules; CAR-T, chimeric antigen receptor T cell; TCR-T, T-cell receptor engineered T cell.

Apart from the problems associated with its efficacy (only a small group of patients respond to it), immunotherapy faces several challenges related to its safety. In other words, immunotherapy can induce adverse events in patients, such as autoimmunity, where healthy tissues are attacked, or cytokine release syndrome and vascular leak syndrome, as observed with the use of IL-2, both of which lead to serious hypotension, fever, renal failure, and other adverse events that are potentially lethal. The main challenges to be faced by immunotherapy in the future will require the combined efforts of basic and clinical scientists, with the objective of accelerating the understanding of the complex interactions between cancer and the immune system, and improve treatment options for patients. Better comprehension of immune phenotypes in tumors, beyond the state of PD-L1 and TME, will be relevant to increase immunotherapy efficacy. In this context, the identification of precise tumor antigenicity biomarkers by means of new technologies, such as complete genome sequencing, single cell sequencing, and epigenetic analysis to identify sites or subclones typical in drug resistance, as well as activation, traffic and infiltration of effector cells of the immune response, and regulation of TME mechanisms, may help define patient populations that are good candidates for specific therapies and therapeutic combinations. 117 , 118 Likewise, the use of agents that can induce specific activation and modulation of the response of T cells in tumor tissue, will help improve efficacy and safety profiles that can lead to better clinical results.

Molecular Targeted Therapy

For over 30 years, and based on the progress in our knowledge of tumor biology and its mechanisms, there has been a search for therapeutic alternatives that would allow spread and growth of tumors to be slowed down by blocking specific molecules. This approach is known as molecular targeted therapy. 119 Among the elements generally used as molecular targets there are transcription factors, cytokines, membrane receptors, molecules involved in a variety of signaling pathways, apoptosis modulators, promoters of angiogenesis, and cell cycle regulators. 120

Imatinib, a tyrosine kinase inhibitor for the treatment of chronic myeloid leukemia, became the first targeted therapy in the final years of the 1990s. 97 From then on, new drugs have been developed by design, and today more than 60 targeted therapies have been approved by the FDA for the treatment of a variety of cancers ( Table 3 ). 121 This has had a significant impact on progression-free survival and global survival in neoplasms such as non-small cell lung cancer, breast cancer, renal cancer, and melanoma.

FDA Approved Molecular Targeted Therapies for the Treatment of Solid Tumors.

Abbreviations: mAb, monoclonal antibody; ALK, anaplastic lymphoma kinase; CDK, cyclin-dependent kinase; CTLA-4, cytotoxic lymphocyte antigen-4; EGFR, epidermal growth factor receptor; FGFR, fibroblast growth factor receptor; GIST, gastrointestinal stroma tumor; mTOR, target of rapamycine in mammal cells; NSCLC, non-small cell lung carcinoma; PARP, poli (ADP-ribose) polimerase; PD-1, programmed death protein-1; PDGFR, platelet-derived growth factor receptor; PD-L1, programmed death ligand-1; ER, estrogen receptor; PR, progesterone receptor; TKR, tyrosine kinase receptors; SERM, selective estrogen receptor modulator; TKI, tyrosine kinase inhibitor; VEGFR, vascular endothelial growth factor receptor. Modified from Ref. [ 127 ].

Most drugs classified as targeted therapies form part of 2 large groups: small molecules and mAbs. The former are defined as compounds of low molecular weight (<900 Daltons) that act upon entering the cell. 120 Targets of these compounds are cell cycle regulatory proteins, proapoptotic proteins, or DNA repair proteins. These drugs are indicated based on histological diagnosis, as well as molecular tests. In this group there are multi-kinase inhibitors (RTKs) and tyrosine kinase inhibitors (TKIs), like sunitinib, sorafenib, and imatinib; cyclin-dependent kinase (CDK) inhibitors, such as palbociclib, ribociclib and abemaciclib; poli (ADP-ribose) polimerase inhibitors (PARPs), like olaparib and talazoparib; and selective small-molecule inhibitors, like ALK and ROS1. 122

As for mAbs, they are protein molecules that act on membrane receptors or extracellular proteins by interrupting the interaction between ligands and receptors, in such a way that they reduce cell replication and induce cytostasis. Among the most widely used mAbs in oncology we have: trastuzumab, a drug directed against the receptor for human epidermal growth factor-2 (HER2), which is overexpressed in a subgroup of patients with breast and gastric cancer; and bevacizumab, that blocks vascular endothelial growth factor and is used in patients with colorectal cancer, cervical cancer, and ovarian cancer. Other mAbs approved by the FDA include pembolizumab, atezolizumab, nivolumab, avelumab, ipilimumab, durvalumab, and cemiplimab. These drugs require expression of response biomarkers, such as PD-1 and PD-L1, and must also have several resistance biomarkers, such as the expression of EGFR, the loss of PTEN, and alterations in beta-catenin. 123

Because cancer is such a diverse disease, it is fundamental to have precise diagnostic methods that allow us to identify the most adequate therapy. Currently, basic immunohistochemistry is complemented with neoplastic molecular profiles to determine a more accurate diagnosis, and it is probable that in the near future cancer treatments will be based exclusively on molecular profiles. In this regard, it is worth mentioning that the use of targeted therapy depends on the existence of specific biomarkers that indicate if the patient will be susceptible to the effects of the drug or not. Thus, the importance of underlining that not all patients are susceptible to receive targeted therapy. In certain neoplasms, therapeutic targets are expressed in less than 5% of the diagnosed population, hindering a more extended use of certain drugs.

The identification of biomarkers and the use of new generation sequencing on tumor cells has shown predictive and prognostic relevance. Likewise, mutation analysis has allowed monitoring of tumor clone evolution, providing information on changes in canonic gene sequences, such as TP53, GATA3, PIK3CA, AKT1, and ERBB2; infrequent somatic mutations developed after primary treatments, like SWI-SNF and JAK2-STAT3; or acquired drug resistance mutations such as ESR1. 124 The study of mutations is vital; in fact, many of them already have specific therapeutic indications, which have helped select adequate treatments. 125

There is no doubt that molecular targeted therapy is one of the main pillars of precision medicine. However, it faces significant problems that often hinder obtaining better results. Among these, there is intratumor heterogeneity and differences between the primary tumor and metastatic sites, as well as intrinsic and acquired resistance to these therapies, the mechanisms of which include the presence of heterogeneous subclones, DNA hypermethylation, histone acetylation, and interruption of mRNA degradation and translation processes. 126 Nonetheless, beyond the obstacles facing molecular targeted therapy from a biological and methodological point of view, in the real world, access to genomic testing and specific drugs continues to be an enormous limitation, in such a way that strategies must be designed in the future for precision medicine to be possible on a global scale.

Cell Therapy

Another improvement in cancer treatment is the use of cell therapy, that is, the use of specific cells as therapeutic agents. This clinical procedure has 2 modalities: the first consists of replacing and regenerating functional cells in a specific tissue by means of stem/progenitor cells of a certain kind, 43 while the second uses immune cells as effectors to eliminate malignant cells. 127

Regarding the first type, we must emphasize the development of cell therapy based on hematopoietic stem and progenitor cells. 128 For over 50 years, hematopoietic cell transplants have been used to treat a variety of hematologic neoplasms (different forms of leukemia and lymphoma). Today, it is one of the most successful examples of cell therapy, including innovative modalities, such as haploidentical transplants, 129 as well as application of stem cells expanded ex vivo . 130 There are also therapies that have used immature cells that form part of the TME, such as MSCs. The replication potential and cytokine secretion capacity of these cells make them an excellent option for this type of treatment. 131 Neural stem cells can also be manipulated to produce and secrete apoptotic factors, and when these cells are incorporated into primary neural tumors, they cause a certain degree of regression. They can even be transfected with genes that encode for oncolytic enzymes capable of inducing regression of glioblastomas. 132

With respect to cell therapy using immune cells, several research groups have manipulated cells associated with tumors to make them effector cells and thus improve the efficacy and specificity of the antitumor treatment. PB leckocytes cultured in the presence of IL-2 to obtain activated lymphocytes, in combination with IL-2 administration, have been used in antitumor clinical protocols. Similarly, infiltrating lymphocytes from tumors with antitumor activity have been used and can be expanded ex vivo with IL-2. These lymphocyte populations have been used in immunomodulatory therapies in melanoma, and pancreatic and kidney tumors, producing a favorable response in treated patients. 133 NK cells and macrophages have also been used in immunotherapy, although with limited results. 134 , 135

One of the cell therapies with better projection today is the use of CAR-T cells. This strategy combines 2 forms of advanced therapy: cell therapy and gene therapy. It involves the extraction of T cells from the cancer patient, which are genetically modified in vitro to express cell surface receptors that will recognize antigens on the surface of tumor cells. The modified T cells are then reintroduced in the patient to aid in an exacerbated immune response that leads to eradication of the tumor cells ( Figure 4 ). Therapy with CAR-T cells has been used successfully in the treatment of some types of leukemia, lymphoma, and myeloma, producing complete responses in patients. 136

CAR-T cell therapy. (A) T lymphocytes obtained from cancer patients are genetically manipulated to produce CAR-T cells that recognize tumor cells in a very specific manner. (B) Interaction between CAR molecule and tumor antigen. CAR molecule is a receptor that results from the fusion between single-chain variable fragments (scFv) from a monoclonal antibody and one or more intracellular signaling domains from the T-cell receptor. CD3ζ, CD28 and 4-1BB correspond to signaling domains on the CAR molecule.

Undoubtedly, CAR-T cell therapy has been truly efficient in the treatment of various types of neoplasms. However, this therapeutic strategy can also have serious side effects, such as release of cytokines into the bloodstream, which can cause different symptoms, from high fever to multiorgan failure, and even neurotoxicity, leading to cerebral edema in many cases. 137 Adequate control of these side effects is an important medical challenge. Several research groups are trying to improve CAR-T cell therapy through various approaches, including production of CAR-T cells directed against a wider variety of tumor cell-specific antigens that are able to attack different types of tumors, and the identification of more efficient types of T lymphocytes. Furthermore, producing CAR-T cells from a single donor that may be used in the treatment of several patients would reduce the cost of this sort of personalized cell therapy. 136

Achieving wider use of cell therapy in oncologic diseases is an important challenge that requires solving various issues. 138 One is intratumor cell heterogeneity, including malignant subclones and the various components of the TME, which results in a wide profile of membrane protein expression that complicates finding an ideal tumor antigen that allows specific identification (and elimination) of malignant cells. Likewise, structural organization of the TME challenges the use of cell therapy, as administration of cell vehicles capable of recognizing malignant cells might not be able to infiltrate the tumor. This results from low expression of chemokines in tumors and the presence of a dense fibrotic matrix that compacts the inner tumor mass and avoids antitumor cells from infiltrating and finding malignant target cells.

Further Challenges in the 21st Century

Beyond the challenges regarding oncologic biomedical research, the 21 st century is facing important issues that must be solved as soon as possible if we truly wish to gain significant ground in our fight against cancer. Three of the most important have to do with prevention, early diagnosis, and access to oncologic medication and treatment.

Prevention and Early Diagnosis

Prevention is the most cost-effective strategy in the long term, both in low and high HDI nations. Data from countries like the USA indicate that between 40-50% of all types of cancer are preventable through potentially modifiable factors (primary prevention), such as use of tobacco and alcohol, diet, physical activity, exposure to ionizing radiation, as well as prevention of infection through access to vaccination, and by reducing exposure to environmental pollutants, such as pesticides, diesel exhaust particles, solvents, etc. 74 , 84 Screening, on the other hand, has shown great effectiveness as secondary prevention. Once population-based screening programs are implemented, there is generally an initial increase in incidence; however, in the long term, a significant reduction occurs not only in incidence rates, but also in mortality rates due to detection of early lesions and timely and adequate treatment.

A good example is colon cancer. There are several options for colon cancer screening, such as detection of fecal occult blood, fecal immunohistochemistry, flexible sigmoidoscopy, and colonoscopy, 139 , 140 which identify precursor lesions (polyp adenomas) and allow their removal. Such screening has allowed us to observe 3 patterns of incidence and mortality for colon cancer between the years 2000 and 2010: on one hand, an increase in incidence and mortality in countries with low to middle HDI, mainly countries in Asia, South America, and Eastern Europe; on the other hand, an increase in incidence and a fall in mortality in countries with very high HDI, such as Canada, the United Kingdom, Denmark, and Singapore; and finally a fall in incidence and mortality in countries like the USA, Japan, and France. The situation in South America and Asia seems to reflect limitations in medical infrastructure and a lack of access to early detection, 141 while the patterns observed in developed countries reveal the success, even if it may be partial, of that which can be achieved by well-structured prevention programs.

Another example of success, but also of strong contrast, is cervical cancer. The discovery of the human papilloma virus (HPV) as the causal agent of cervical cancer brought about the development of vaccines and tests to detect oncogenic genotypes, which modified screening recommendations and guidelines, and allowed several developed countries to include the HPV vaccine in their national vaccination programs. Nevertheless, the outlook is quite different in other areas of the world. Eighty percent of the deaths by cervical cancer reported in 2018 occurred in low-income nations. This reveals the urgency of guaranteeing access to primary and secondary prevention (vaccination and screening, respectively) in these countries, or else it will continue to be a serious public health problem in spite of its preventability.

Screening programs for other neoplasms, such as breast, prostate, lung, and thyroid cancer have shown outlooks that differ from those just described, because, among other reasons, these neoplasms are highly diverse both biologically and clinically. Another relevant issue is the overdiagnosis of these neoplasms, that is, the diagnosis of disease that would not cause symptoms or death in the patient. 142 It has been calculated that 25% of breast cancer (determined by mammogram), 50–60% of prostate cancer (determined by PSA), and 13–25% of lung cancer (determined by CT) are overdiagnosed. 142 Thus, it is necessary to improve the sensitivity and specificity of screening tests. In this respect, knowledge provided by the biology of cancer and “omic” sciences offers a great opportunity to improve screening and prevention strategies. All of the above shows that prevention and early diagnosis are the foundations in the fight against cancer, and it is essential to continue to implement broader screening programs and better detection methods.

Global Equity in Oncologic Treatment

Progress in cancer treatment has considerably increased the number of cancer survivors. Nevertheless, this tendency is evident only in countries with a very solid economy. Indeed, during the past 30 years, cancer mortality rates have increased 30% worldwide. 143 Global studies indicate that close to 70% of cancer deaths in the world occur in nations of low to middle income. But even in high-income countries, there are sectors of society that are more vulnerable and have less access to cancer treatments. 144 Cancer continues to be a disease of great social inequality.

In Europe, the differences in access to cancer treatment are highly marked. These treatments are more accessible in Western Europe than in its Eastern counterpart. 145 Furthermore, highly noticeable differences between high-income countries have been detected in the cost of cancer drugs. 146 It is interesting to note that in many of these cases, treatment is too costly and the clinical benefit only marginal. Thus, the importance of these problems being approached by competent national, regional, and global authorities, because if these new drugs and therapeutic programs are not accessible to the majority, progress in biomedical, clinical and epidemiological research will have a limited impact in our fight against cancer. We must not forget that health is a universal right, from which low HDI countries must not be excluded, nor vulnerable populations in nations with high HDI. The participation of a well-informed society will also be fundamental to achieve a global impact, as today we must fight not only against the disease, but also against movements and ideas (such as the anti-vaccine movement and the so-called miracle therapies) that can block the medical battle against cancer.

Final Comments

From the second half of the 20th century to the present day, progress in our knowledge about the origin and development of cancer has been extraordinary. We now understand cancer in detail in genomic, molecular, cellular, and physiological terms, and this knowledge has had a significant impact in the clinic. There is no doubt that a patient who is diagnosed today with a type of cancer has a better prospect than a patient diagnosed 20 or 50 years ago. However, we are still far from winning the war against cancer. The challenges are still numerous. For this reason, oncologic biomedical research must be a worldwide priority. Likewise, one of the fundamental challenges for the coming decades must be to reduce unequal access to health services in areas of low- to middle income, and in populations that are especially vulnerable, as well as continue improving prevention programs, including public health programs to reduce exposure to environmental chemicals and improve diet and physical activity in the general population. 74 , 84 Fostering research and incorporation of new technological resources, particularly in less privileged nations, will play a key role in our global fight against cancer.

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding: The author(s) received no financial support for the research, authorship, and/or publication of this article.

Hector Mayani https://orcid.org/0000-0002-2483-3782

Biology Extended Essay Topics and RQs for IBDP

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• Writing Metier

It’s time for our exploration of Biology extended essay topics, a resource designed to spark your curiosity and guide your research interests in the vast and vibrant field of biology. 

Whether you’re fascinated by the intricate workings of ecosystems or intrigued by the complexities of cellular processes, this article offers a diverse range of topics collected by expert academic writers to suit your interests. 

NB! If you need assistance with your Biology assignments, you can use our biology essay writing service , which will surely assist you. Now, let’s get back to the main question of the article – BIO EE topic ideas.

Bio EE topic categories

List of biology extended essay topic categories I’ll cover in this article.

• Impact of Urban Development on Local Ecosystems – Investigating the effects of urban expansion on biodiversity in a specific area.
• Marine Biology and Ocean Acidification – Studying the impact of changing pH levels on marine life.
• Invasive Species and Their Impact on Biodiversity – Analyzing how a particular invasive species has affected native wildlife.
• Conservation Efforts for Endangered Species – Evaluating the effectiveness of current conservation strategies for a specific endangered species.
• Climate Change and Its Effects on Ecosystems – Researching how a particular ecosystem has been impacted by climate change.
• Nutrition and Diet’s Impact on Human Health – Exploring the effects of a specific diet on human health.
• Exercise Physiology – Investigating how different types of exercise affect a particular aspect of human health.
• Neurobiology of Sleep – Studying the effects of sleep patterns on cognitive functions.
• Genetic Factors in Diseases – Exploring the role of genetics in the susceptibility to a specific disease.
• Impact of Environmental Factors on Allergies – Analyzing how environmental changes have influenced the prevalence of allergies.
• Gene Expression in Cancer Cells – Investigating how gene expression differs in cancerous versus normal cells.
• Protein Synthesis and Its Regulation – Studying the regulation of protein synthesis in a specific organism or cell type.
• Stem Cell Research and Regenerative Medicine – Exploring the potential of stem cells in treating a specific condition.
• Viral Replication and Host Interaction – Examining how a particular virus replicates and interacts with its host.
• DNA Repair Mechanisms – Investigating the efficacy of different DNA repair mechanisms under various conditions.
• Photosynthesis Variations Among Plant Species – Comparing photosynthetic efficiency in different plant species.
• Impact of Climate Change on Plant Growth – Studying how changing climates affect the growth of a specific plant species.
• Medicinal Properties of Plants – Investigating the medicinal properties of a specific plant.
• Plant Defense Mechanisms Against Pathogens – Exploring how a particular plant species defends itself against pathogens.
• Genetic Modification and Crop Improvement – Analyzing the impacts of genetic modification on a specific crop’s traits.
• Social Behavior in Insects – Studying the social structures and behaviors of a specific insect species.
• Bird Migration Patterns – Investigating the factors influencing migration patterns of a specific bird species.
• Physiological Adaptations in Marine Mammals – Exploring adaptations that enable marine mammals to survive in their environments.
• Impact of Environmental Stressors on Animal Behavior – Analyzing how specific stressors affect the behavior of a particular animal species.
• Endocrine Regulation in Animals – Studying how the endocrine system regulates processes in a specific animal.
• Antibiotic Resistance in Bacteria – Investigating the mechanisms of antibiotic resistance in a specific bacterial strain.
• Use of Microorganisms in Bioremediation – Exploring the use of microorganisms in cleaning up environmental pollutants.
• Genetic Engineering and Its Applications – Analyzing the applications and implications of genetic engineering in a specific field.
• Role of Microbiome in Human Health – Studying how the human microbiome influences health and disease.
• Yeast Fermentation and Its Industrial Applications – Investigating the fermentation process in yeast and its uses in industry.
• Evolutionary Adaptations to Environmental Changes – Exploring how a particular species has adapted to environmental changes over time.
• Genetic Diversity and Population Health – Studying the impact of genetic diversity on the health of a specific population.
• Molecular Basis of Inheritance – Investigating the molecular mechanisms of inheritance in a specific organism.
• Speciation and Genetic Drift – Analyzing the role of genetic drift in the speciation process.
• Human Evolutionary Biology – Studying aspects of human evolution, such as the development of specific traits.

Every category and its subcategories provide a comprehensive overview, from the microscopic wonders of microbiology to the grand scale of evolutionary biology. 

With the help of our IB writers team, I have managed to collect all these ideas for you, so I hope you will be enjoying this. I aim to inspire your investigative spirit and help you select a topic that  satisfies the IB criteria  and aligns with your passion for biology. 

IB Bio extended essay topics

So, let’s begin with a list of IB Biology EE topics list.

Ecology and Environmental Science

I’m stoked to talk about Ecology and Environmental Science . It’s all about how living things interact with each other and their surroundings. Think of it like a complex dance of life, where every move affects the whole scene. 

From the hustle and bustle of city ecosystems to the quiet, yet dynamic, world of marine biology, we’ll explore how these interactions shape our planet. We’ll also explore the hot topics of invasive species and their impacts, the heroic efforts in conservation, and the big elephant in the room – climate change. 

So, let’s get ready to explore the intricate tapestry of life that makes our world fascinating!

Impact of Urban Development on Local Ecosystems

• Research Question: How does the presence of urban green spaces affect bird species diversity in [City Name]?
• Research Question: What impact do urban heat islands have on the behavior and distribution of [Specific Animal Species] in [City Name]?

Marine Biology and Ocean Acidification

• Research Question: How does ocean acidification affect coral bleaching events in the [Specific Coral Reef Location]?
• Research Question: What is the impact of increasing ocean acidification on the shell growth and survival of [Specific Shellfish Species]?

Invasive Species and Their Impact on Biodiversity

• Research Question: What has been the impact of the invasive Zebra Mussel on native species in the Great Lakes?
• Research Question: How do invasive plant species [Specify Species] affect the growth and survival of native plants in [Specific Region]?

Conservation Efforts for Endangered Species

• Research Question: How effective have conservation strategies been in increasing the population of the Giant Panda in China?
• Research Question: What are the impacts of anti-poaching measures on the survival of Rhinoceros populations in Africa?

Climate Change and Its Effects on Ecosystems

• Research Question: How is the melting of Arctic sea ice affecting the habitat and migration patterns of polar bears?
• Research Question: What are the effects of rising global temperatures on plant and animal life in the Alpine ecosystems?

Transitioning from the external world of Ecology and Environmental Science, we now turn to the internal intricacies of Human Physiology and Health. 

This shift brings us from exploring external ecosystems to understanding our body’s inner workings, a world where lifestyle choices meet biological responses.

Human Physiology and Health

Let’s chat about Human Physiology and Health, the amazing science of how our bodies work and how we keep them ticking. We’re diving headfirst into the world of nutrition and diet – what you eat isn’t just about taste, it’s about your health too! 

Then, we’ll check out how exercise, that thing we all know we should do more of, affects our bodies in awesome ways. Ever wondered about the science of sleep and how it messes with your brain when you don’t catch enough Z’s? We’ll cover that, along with the mysteries of genetics in diseases, and how our environment plays a sneaky role in triggering allergies. 

It’s going to be an eye-opening ride through the wonders of our bodies!

Nutrition and Diet’s Impact on Human Health

• Research Question: How does adherence to the Mediterranean diet affect cardiovascular health indicators in adults?
• Research Question: What is the impact of a long-term vegan diet on nutrient absorption and health in teenagers?

Exercise Physiology

• Research Question: How does HIIT affect cardiovascular fitness in young adults?
• Research Question: What are the effects of regular yoga practice on stress and anxiety levels in college students?

Neurobiology of Sleep

• Research Question: How does sleep deprivation impact cognitive performance and memory in high school students?
• Research Question: What is the relationship between sleep patterns and academic performance in IB students?

Genetic Factors in Diseases

• Research Question: How do specific genetic factors contribute to the risk of developing Alzheimer’s disease?
• Research Question: What is the contribution of genetics to the onset of Type 2 Diabetes in populations with high prevalence rates?

Impact of Environmental Factors on Allergies

• Research Question: What is the correlation between air pollution levels and the prevalence of respiratory allergies in urban children?
• Research Question: How has climate change influenced the prevalence and severity of allergic diseases in [Specific Region]?

Moving from Human Physiology and Health, we zoom into the realm of Cellular and Molecular Biology. 

Here, we swap the broader human health perspective for a closer look at life’s building blocks, delving into the microscopic universe that operates within every living being.

Cellular and Molecular Biology

Ready to geek out on Cellular and Molecular Biology? This is where we get down to the nitty-gritty of life – the cells and molecules that make up every living thing. 

We’re talking about the big bad world of cancer cells and what makes them tick, the fascinating process of how our cells make proteins, and the cutting-edge stuff like stem cell research and how viruses play a game of cat and mouse with our bodies. 

Meanwhile, make sure also to check our article with biology research paper topics for all students.

Plus, we’ll unravel the mysteries of how our cells fix their own DNA. It’s like being a detective, but for biology. Trust me, it’s cooler than it sounds!

Gene Expression in Cancer Cells

• Research Question: How does gene expression in breast cancer cells differ from that in normal breast tissue?
• Research Question: What role do specific oncogenes play in the development of colorectal cancer?

Protein Synthesis and Its Regulation

• Research Question: How is protein synthesis regulated in response to physical exercise in human muscle cells?
• Research Question: How do bacterial cells regulate protein synthesis under environmental stress conditions?

Stem Cell Research and Regenerative Medicine

• Research Question: What is the potential of stem cell therapy in the treatment of Parkinson’s Disease?
• Research Question: How can stem cells be used to repair damaged heart tissue?

Viral Replication and Host Interaction

• Research Question: How does HIV replicate within human cells, and what is its impact on the immune system?
• Research Question: How does the Influenza virus adapt to host immune responses over time?

DNA Repair Mechanisms

• Research Question: How do DNA repair mechanisms change as human cells age?
• Research Question: How effective are DNA repair mechanisms in skin cells exposed to different levels of UV radiation?

After diving into the microcosm of cells and molecules, we transition to Plant Biology. 

This shift steers us from the foundations of life at the cellular level to the diverse world of plants, exploring how these organisms harness and embody basic biological principles.

Plant Biology

Let’s dive into the world of Plant Biology! Plants are not just pretty to look at; they’re the backbone of all life on Earth. 

We’ll be talking about how they turn sunlight into food – a process that’s as important as it is fascinating. Ever wonder how plants are coping with our changing climate or what superpowers medicinal plants have? We’ve got that covered. 

We’ll also explore the secret life of plants, how they defend themselves against enemies, and the science behind making them stronger and better through genetic modification. 

It’s time to get our hands dirty and uncover the secrets of the plant world!

Photosynthesis Variations Among Plant Species

• Research Question: How does photosynthetic efficiency compare between C3 and C4 plants under varying light conditions?
• Research Question: What is the effect of varying light intensities on the rate of photosynthesis in [Specific Aquatic Plant Species]?

Impact of Climate Change on Plant Growth

• Research Question: How are Arctic tundra plants adapting their growth patterns in response to global warming?
• Research Question: What is the impact of elevated atmospheric CO2 levels on the growth of [Specific Plant Species]?

Medicinal Properties of Plants

• Research Question: What are the anti-inflammatory properties of [Specific Medicinal Plant] and how can they be harnessed?
• Research Question: What is the antioxidant capacity of different herbal teas, and how does it affect human health?

Plant Defense Mechanisms Against Pathogens

• Research Question: How do [Specific Plant Species] defend themselves against fungal infections?
• Research Question: What role do secondary metabolites play in the defense mechanisms of [Specific Plant Species] against herbivores?

Genetic Modification and Crop Improvement

• Research Question: How effective are genetically modified crops in resisting drought conditions compared to traditional varieties?
• Research Question: What is the impact of genetic modification on the nutrient content of [Specific Crop]?

From the stationary life of plants, we now step into the dynamic world of Animal Behavior and Physiology. This change of scene introduces us to the complex behaviors and physiological adaptations of animals, offering a contrasting perspective to plant biology.

Animal Behavior and Physiology

Let’s jump into the wild and wonderful world of Animal Behavior and Physiology. This is where we get to spy on the animal kingdom and learn about their secret lives. 

From the social gossip of insects to the globe-trotting adventures of migratory birds, animals have some amazing stories to tell. 

We’ll also look at how marine animals have adapted to their deep and mysterious homes, how animals respond when their environment goes bonkers, and the hormonal soap operas that dictate their lives. 

It’s like being a fly on the wall in the most interesting nature documentary ever!

Social Behavior in Insects

• Research Question: How does the social structure of honeybee colonies affect their survival and productivity?
• Research Question: What are the primary communication mechanisms used in ant colonies, and how do they impact colony efficiency?

Bird Migration Patterns

• Research Question: How has climate change affected the migration routes of [Specific Bird Species]?
• Research Question: How do magnetic fields influence the migration patterns of [Specific Bird Species]?

Physiological Adaptations in Marine Mammals

• Research Question: What physiological adaptations allow sperm whales to dive to extreme depths?
• Research Question: How do polar bears regulate their body temperature in the Arctic environment?

Impact of Environmental Stressors on Animal Behavior

• Research Question: How does underwater noise pollution affect the behavior and communication of dolphins?
• Research Question: What are the effects of urban light pollution on the nocturnal activities of [Specific Nocturnal Animal Species]?

Endocrine Regulation in Animals

• Research Question: How do hormones regulate the reproductive behaviors in [Specific Bird Species]?
• Research Question: How do stress-induced cortisol levels affect the behavior of [Specific Wild Animal Species] in their natural habitat?

Leaving the observable world of animals, we enter the less visible but equally important sphere of Microbiology and Biotechnology. This transition takes us from larger life forms to the microscopic, where tiny organisms significantly impact our health, environment, and technology.

Microbiology and Biotechnology

Alright, microbe hunters and tech wizards, it’s time to zoom in on Microbiology and Biotechnology. This is the world of the tiny, where bacteria and viruses hang out, and where science meets innovation . 

We’re going to explore the battleground of antibiotic resistance, how we can use tiny organisms to clean up our messes, and the mind-blowing possibilities of genetic engineering. 

Ever thought about how your gut buddies – the microbiome – affect your health? We’ll get into that too, along with the yeast party that’s behind some of your favorite bread and beverages.

Antibiotic Resistance in Bacteria

• Research Question: What factors have contributed to the rise of Methicillin-resistant Staphylococcus aureus (MRSA) in hospitals?
• Research Question: What are the primary mechanisms of antibiotic resistance in Escherichia coli strains found in [Specific Environment]?

Use of Microorganisms in Bioremediation

• Research Question: How effective are specific bacterial species in the bioremediation of oil spills?
• Research Question: What is the effectiveness of using fungi in the phytoremediation of soils contaminated with heavy metals?

Genetic Engineering and Its Applications

• Research Question: What is the potential of CRISPR-Cas9 technology in preventing genetic diseases?
• Research Question: How has genetic engineering been used to enhance the nutritional quality of [Specific Crop]?

Role of Microbiome in Human Health

• Research Question: What is the relationship between the gut microbiome and obesity in adults?
• Research Question: How does the diversity of the human microbiome affect immune system functioning?

Yeast Fermentation and Its Industrial Applications

• Research Question: How efficient is yeast fermentation in the production of biofuels compared to traditional methods?
• Research Question: How do different yeast strains affect the flavor profiles in beer brewing?

Finally, we shift from the practical applications in Microbiology and Biotechnology to the historical narrative of Evolution and Genetics. This move links present-day biological understanding to the historical journey of life, unraveling how genetic heritage and evolutionary processes shape all living things.

Evolution and Genetics

Ready to unravel the tales of Evolution and Genetics? This is where we figure out how life on Earth got to be as diverse and fantastic as it is. We’ll be exploring the incredible adaptations organisms have made to survive and thrive, how genetic diversity is crucial for the health of species, and the molecular secrets behind inheritance. 

Ever pondered how new species come into being or what genetics reveal about our own ancient history ? Well, you’re in for a treat. We’re about to walk through time and genes to discover the roots and branches of the tree of life. Buckle up!

Evolutionary Adaptations to Environmental Changes

• Research Question: What evolutionary adaptations have enabled cacti to thrive in harsh desert environments?
• Research Question: How have Galápagos finches undergone adaptive radiation in response to their environment?

Genetic Diversity and Population Health

• Research Question: How does genetic diversity affect the health and survival of animal populations on isolated islands?
• Research Question: How can conservation genetics be used to enhance the survival prospects of [Specific Endangered Species]?

Molecular Basis of Inheritance

• Research Question: What is the molecular basis of inheritance for Sickle Cell Anemia?
• Research Question: How can mitochondrial DNA be used to trace maternal lineage in human populations?

Speciation and Genetic Drift

• Research Question: What role has genetic drift played in the speciation of cichlids in Lake Victoria?
• Research Question: How does genetic drift affect the genetic diversity of small, isolated animal populations?

Human Evolutionary Biology

• Research Question: What evolutionary factors contributed to the development of bipedalism in early humans?
• Research Question: What are the key genetic adaptations that enable humans to live at high altitudes?

These topics and questions aim to inspire in-depth exploration and research, allowing students to delve into various aspects of biology, from molecular to ecosystem levels. 

Use them as an inspiration for your future Ib extended essay.

Select your topic wisely!

The world of biology is rich with diverse topics suitable for an Extended Essay. From the tiny intricacies of cellular biology to the broad complexities of environmental science, each area offers a unique perspective and a chance for in-depth exploration . 

The key to a successful essay is choosing a topic that not only interests you but also challenges your analytical and research skills.

Need Extra Support?

If you’re seeking guidance with your topic selection, or if you need assistance in writing or editing your Biology Extended Essay , our team at Writing Metier is here to help. 

Our experienced IB writers are equipped to provide the support you need to refine your ideas and enhance your writing. Contact us for personalized assistance, or simply fill out our online order form with details of your IB EE and ensure your essay is a reflection of your best efforts.

Free topic suggestions

Vasy kafidoff.

Vasyl Kafidoff is a co-founder and CEO at WritingMetier. He is interested in education and how modern technology makes it more accessible. He wants to bring awareness about new learning possibilities as an educational specialist. When Vasy is not working, he’s found behind a drum kit.

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• Frontiers in Dental Medicine
• Systems Integration
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Craniofacial Defects: Advancing Functional Reconstruction Strategies for Improved Outcomes

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Craniofacial defects encompass a range of deformities affecting the skull, facial bones, and soft tissues, often resulting from trauma, genetic diseases, or abnormal embryonic development. These defects can have severe implications, including intellectual disability and visual impairment, necessitating functional reconstruction for optimal patient outcomes. However, despite extensive research in both clinical and basic sciences, the development of novel and effective strategies for craniofacial defect reconstruction remains an ongoing challenge. To address this gap in knowledge, we invite original research, case reports, and review papers that explore various aspects of functional reconstruction for craniofacial defects. Specifically, we seek contributions that delve into the following areas: -Advanced clinical investigations, showcasing current functional reconstruction strategies and surgical techniques, and their efficacy in treating craniofacial defects -Cell biology and biomedical technology for reconstructing craniofacial defects -Immunotherapeutic strategy to manipulate oral inflammation-caused craniofacial defects, such as maxillofacial bone loss, craniofacial muscle fibrosis, facial skin scar, etc -Application of computational technology, artificial intelligence, and additive manufacturing technology in treating craniofacial defects, including the defects that happen after oral oncology treatment. -Advancements in basic science research, investigating the genetic changes, etiology, and pathogenesis of craniofacial defects to facilitate the exploration of new therapeutic strategies. -Other related research and reviews that contribute to our understanding of craniofacial defects and their management. By collating and sharing the latest insights in this field, we aim to accelerate progress in functional reconstruction, ultimately improving the quality of life for individuals with craniofacial defects.

Keywords : craniofacial defects, genetic disease, embryonic development, trauma

Important Note : All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Why Some Companies Grow Amid Uncertainty — and Others Don’t

• Simon Freakley
• David Garfield

A survey of 3,000 global executives suggests that it’s not strategic thinking that sets them apart. It’s their inclination to move quickly.

When you cannot base strategy on reasonably certain premises — or when those reasonable premises are undone by unforeseeable events — what is a company to do? You still have to make plans, allocate capital, and invest for the future. Some argue that agility is the key to thriving in disruptive times, but if all you do is pivot, you are just going around in circles. The annual AlixPartners Disruption Index surveys 3,000 global executives about what is knocking them sideways. Among other things, it shows that three out of five say that it is increasingly challenging to know which disruptive forces to prioritize. Amid all this, there is a group of companies doing very well: about one in five said their companies lead their industry in revenue growth. In this article, the authors dig into that 2024 data to find out what sets these companies apart, and what other companies can learn from them about setting growth strategy in an uncertain world.

Strategic planning plays a key role in helping companies anticipate and manage business cycles. But forces like emerging digital technologies, climate change, and deglobalization — not to mention “black swan” events like the Covid-19 pandemic and wars — have turned a rolling sea into a choppy one, where companies are beset by currents, crosscurrents, riptides, and squalls. This multiplicity of related, unrelated, and inter-related difficulties have one thing in common: They are unpredictable.

• SF Simon Freakley is the Chief Executive Officer of AlixPartners, a post he has held since 2015. He is based in New York.
• David Garfield is a Chicago-based partner and managing director of AlixPartners, and the global leader for the firm’s industry practices.

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