bench work research

• Basic Science

All scientific research conducted at medical schools and teaching hospitals ultimately aims to improve health and ability.  Basic science research —often called fundamental or bench research—provides the foundation of knowledge for the applied science that follows. This type of research encompasses familiar scientific disciplines such as biochemistry, microbiology, physiology, and pharmacology, and their interplay, and involves laboratory studies with cell cultures, animal studies or physiological experiments. Basic science also increasingly extends to behavioral and social sciences as well, which have no less profound relevance for medicine and health.

Basic research can address clinical issues from a reductionist approach, including the discovery and analysis of single genes or genetic markers of diseases, or sequencing and manipulating genes. Typically, basic science research focuses on determining the causal mechanisms behind the functioning of the human body in health and illness, and utilizes hypothesis-driven experimental designs that can be specifically tested and revised. More recently, “systems biology” has focused on understanding how complex systems arise from elemental processes. Once these fundamental principles of the biologic processes are understood, these discoveries can be applied or translated into direct application to patient care. 

In the absence of information and insights generated from basic research, it is difficult to envision how future advancement in treatment of disease and disability will occur; physicians would increasingly be in the position of mechanics who do not know how engines work, or programmers who do not understand how computers store and compile information. Basic research is also a source for new tools, models, and techniques (e.g., knockout mice, functional magnetic resonance imaging, etc.) that revolutionize research and development beyond the disciplines that give rise to them. 

Federal Support for Medical Research and AAMC’s Role

The AAMC advocates for basic research, as part of the continuum from laboratory-based science to clinical and translational investigation to studies in and with communities and whole populations. The Association strongly supports the work of the U.S. National Institutes of Health (NIH), the American people’s leading organization in support of basic as well as general health research, reflected in the NIH mission statement:

To seek fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to enhance health, lengthen life, and reduce illness and disability.

We also support the Agency for Healthcare Research and Quality, the Centers for Disease Control and Prevention, the Department of Veterans Affairs, and other agencies and organizations that sponsor or conduct medical research.

In addition to advocacy , the AAMC also provides analysis and advice on development of policies and regulations that guide basic and other research. The peer review (or merit review) is one example of a critically important system necessary for supporting the research enterprise. AAMC also examines federal and institutional policies promoting team science (increasingly important to research across the continuum) and the advancement and promotion of individual scientists working collaboratively within teams. We also support professional development programs for senior leaders of research programs at medical schools and teaching hospitals, and for those who guide training and career development of new scientists.

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Bench-to-Bedside Research

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The Stanford Center for Clinical and Translational Research and Education, called Spectrum, is a Stanford independent research center partially funded by a Clinical and Translational Science Award from the National Institutes of Health. Its goal is to accelerate and enhance medical research, from basic discovery to improved patient care. 

Freidenrich Center for Translational Research

The Freidenrich Center   is a state-of-the-art facility for conducting human-subject clinical trials. Available for use by all Stanford researchers, the center features 27 patient stations, an infusion center, a sample-collection lab and a pediatric area. It is also home to staff members of Spectrum and the Stanford Cancer Institute. 

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This biomedical technology innovation program assembles teams of medical, engineering and business students to develop solutions to address unmet medical needs. It includes fellowships, innovation grants, med-tech innovation classes, mentoring in the technology transfer process, career services and community educational events. 

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This drug-discovery program teaches an innovative way to overcome the hurdles associated with translating discoveries into therapeutics that address real clinical needs. It offers innovation grants, lab access, and mentors in drug discovery, product development, trial design, regulatory science and intellectual property law.

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The Stanford Predictives and Diagnostics Accelerator program supports projects that predict the onset or course of disease and improve health. It offers innovation grants, events and mentors in the areas of discovery, development, trial design, regulations and intellectual property law.

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Bench science

K heran darwin.

1 New York University Grossman School of Medicine, New York NY, USA

PIs do not need to stay away from bench work; in fact, they are often overall the best and most experienced experimentalists in the lab.

One the most useful pieces of advice I can give to a new faculty member is that you should be—and probably are—the best experimentalist in your lab. That may sound obvious, but what I often find is that many of us lab heads try to get away from the bench as fast as possible. It is somewhat startling given most of us got into science because we like using our hands and discovering things. In fact, many trainees often say they do not want to be a principal investigator (PI) because they like doing experiments and want to stay at the bench. PIs‐to‐be: rest assured, you can do experiments long into your career if you want to!

During the first few years of independence, we are still young, active, and excited to make our mark. You might not immediately have the heavy teaching burden that certain institutions will eventually require, so embrace this “protected” time: being in the lab with trainees is fun. You are your lab’s best source of information and inspiration. Perhaps our most important discovery happened when I was an assistant professor working side‐by‐side with two outstanding students in a small lab in a very old building. Those early days of eager excitement of discovery are something I cherish, even though there were growing pains during that time as well.

I remember when my Ph.D. mentor, Virginia Miller, would occasionally come into the lab and offer to help with experiments. She would jump at the chance to make “mini mickies,” her protocol for making genomic DNA from bacteria. Her preps were the best; it was only after I watched her isolate DNA from Salmonella that I realized what I was doing wrong, knowledge that I have passed on to my own trainees. In addition to her having fun in the lab, she taught us practical knowledge, which I suspect made her happy.

As your lab grows, the obligations do as well, and you will eventually rely on lab members to run things. If you are well‐funded, perhaps you can hire a lab manager, and if you are lucky, they will be almost as good as you. However, what I have observed over the years is that labs often go to heck when the boss is not around, even if only briefly. I can guarantee you that all of my colleagues who have not been active in the lab for even just a few months are horrified to see the shocking behavior that goes on. Methods and lab rules become a game of “telephone operator”; what was perhaps a well‐oiled protocol becomes a slipshod shadow of its former self. Poorly maintained or broken equipment often goes unreported, reagents go dry. Compliance can also go by the wayside, with lab safety rules taken as suggestions rather than as mandates. These above reasons are just a few that I believe make it important for lab heads to “keep their hand in” at the bench, even if just ever‐so briefly.

People might find it surprising that after 17 years of running a lab, I still work at the bench. No, it is not every day, and time can go by when my bench accumulates more dust or items for repair than Petri plates or used pipet tips; but I make it a point to do experiments every year, usually in the summer when teaching and travel obligations slow down. I just learned from my close friend and collaborator at UC Berkeley, Sarah Stanley, that she, too, tries to have summer projects. As she says, “it's good for morale, it's good for the lab…I try to work out difficult things and techniques people have trouble with.”

The pandemic has also forced many of us lab bosses getting back to the bench. During the first wave of COVID‐19, when labs were allowed only one or two workers, it was myself—and probably many PIs—who checked in on long‐running experiments and kept projects moving. In the summer of 2020, I was routinely seeing my colleague Victor Torres collecting clinical bacterial isolates from COVID‐19 patients on blood agar plates when no one else was allowed to come to work. At around the same time, I was up for a grant renewal, and had to think about new ideas, design experiments, and execute them to get the preliminary data to keep my lab running before everyone came back. When push comes to shove, many lab heads still get the job done. While watching a trainee develop into an able scientist is the greatest joy I derive from my job—and for what it's worth, I believe the best science in my lab is trainee‐driven—being able to do experiments myself is a close second.

When I tell some of my colleagues that I still do experiments, I often get the “wow, I don’t know if I remember how to do that!” or “I don’t even know where anything is!” answer. After wincing a little, I usually respond, “I’m sure you do, it’s like riding a bike”. I have wondered if I was unusual in my bench endeavors, as if I should move away from experimenting despite having the time, energy and strength to do it —let us face it, bench work can be very physical. However, this was a misguided emotion and I have been incredibly inspired by numerous colleagues over the years who still work at the bench and are wildly successful. Melanie Blokesch at the EPFL in Switzerland regularly tweets about her experimental exploits in Vibrio cholerae . Steve Lory from Harvard Medical School recently told me he does experiments 7 days a week when he is in town. In another example, I was on a Zoom happy hour with friends from the ubiquitin‐proteasome field and witnessed Tom Rapoport—an HHMI Investigator and National Academy of Sciences member at Harvard Medical School—loading a protein gel on camera! I recently met Kelly Hughes from the University of Utah, and his infectious excitement for doing bacterial genetics himself was something to behold. Lately I have been finding myself sitting at a biosafety cabinet in our biocontainment facility, setting up experiments with Mycobacterium tuberculosis . Rather than grumble, I have actual moments of Zen when working in the facility.

I am fairly certain that no PhD candidate enters a program because they look forward to writing grants and papers. While these downsides of the job are not as difficult as one might think, the best part of being a PI is thinking about questions to ask and showing people how to answer them experimentally. However, doing the occasional experiment myself is a big bonus. A few moments ago, I just happened to ask my husband if he was planning on going to the lab the day after Thanksgiving, he answered, “It depends, I have to see how my experiments are going.” For those readers who hope they can continue to have work in the lab while running it, keep faith alive!

EMBO Reports (2022) 23 : e54435. [ PMC free article ] [ PubMed ] [ Google Scholar ]

K Heran Darwin is a regular columnist for EMBO reports .

Bench work and clinical relevance: a new strategy in pathology education

Affiliation.

• 1 Department of Haematology, The Canberra Hospital, Yamba Drive, Garran, Canberra, ACT 2606, Australia. [email protected]
• PMID: 18985525
• DOI: 10.1080/00313020802436436

Introduction: It is recognised that medical students' perceptions of pathology can be improved by presenting pathology curricula in a clinically oriented manner. This study investigated how pathology teaching could be made more clinically relevant, using the coagulation laboratory practical for Year 2 students at the Australian National University Medical School as a case study, with a particular focus on the role of laboratory bench work.

Methods: An e-survey was posted to 80 medical students who participated in the coagulation practical in 2005, followed by in-depth interviews for four consenting students. Four teachers were also interviewed to obtain additional perspectives.

Results: Students and teachers showed markedly different views of the clinical relevance of the practical; however, most were in favour of bench work. Greater clinical orientation was the predominant objective identified to improve the practical. Incorporation of laboratory bench-work within case-based sessions, in small group settings, were the strategies recommended to achieve these.

Discussion: A model for a 2 hour laboratory practical is proposed, involving a case-based session incorporating bench work, followed by case discussion to integrate laboratory results with clinical management. This approach is likely to be effective in pathology teaching across all disciplines.

• Education, Medical, Undergraduate / methods*
• Laboratories*
• Pathology, Clinical / education*
• Teaching / methods*

Improving Laboratory Efficiency: A Guide to Laboratory Work Benches

In the ever-evolving world of scientific research, laboratory work benches play a pivotal role in fostering productivity, safety, and organization. These workspaces serve as the foundation upon which experiments and discoveries are built. We will look at the key features needed for your next bench purchase, exploring their significance, key features, and the best practices for optimizing laboratory spaces and getting the most out of your space.

The Significance of Laboratory Work Benches

Laboratory work benches are the backbone of any research facility. They provide scientists and researchers with a dedicated space to conduct experiments, analyze data, and collaborate with colleagues. These workspaces are meticulously designed to meet the unique demands of scientific work, ensuring that experiments are conducted with precision, accuracy, and safety in mind. At iQ Labs , we design and manufacture all our products with the following key features in mind:

Key Features to Consider

Proper layout planning:.

Organize your work benches strategically to minimize movement between different areas and optimize workflow. The iQ Labs Infinity Bench System gives you the ability to build a system around your space, not the other way around. Every lab is unique in both its physical layout and in purpose. Lab benches like the Infinity System is here to let you easily overcome those challenges and adapt your space as changes arise.

Regular Maintenance:

Any bench or table should have clean lines, limited spaces for dirt or contaminants, and should be easily cleanable. Schedule routine maintenance to keep work benches in optimal condition and extend their lifespan.

Work Surface:

A durable and chemical-resistant work surface is critical. Typically, it’s made of materials like epoxy resin, phenolic resin, or stainless steel. The surface should be easy to clean and capable of withstanding the use of chemicals, heat, and physical stress.

Size and Configuration:

Laboratory bench systems come in various sizes and configurations to accommodate different types of research and experiments. Standard configurations typically come with a depth of 30” and widths ranging from 36” up to 96” in 12” increments. Custom sizes can be accommodated for specific applications but are typically not needed due to the broad range of standard sizes offered.

Adjustable Height Work Benches:

Laboratory bench systems and tables adjustability usually falls into two broad categories: pin height adjustable (manual), and power height adjustable. Both of these types can be raised or lowered to accommodate researchers of varying heights, promoting ergonomic comfort and reducing the risk of repetitive strain injuries. To avoid electrical interference with equipment and test procedures within the lab, as well as avoiding the risk of shorting out electrical actuators in a wet lab environment, pin height adjustable tables are considered the standard in most laboratory settings. They are also the more budget-friendly option and don’t have the complexity of a powered system.

Stability and Weight Capacity:

The bench should be stable and capable of supporting the weight of laboratory equipment, instruments, and reagents without wobbling or bending. SEFA approved benches must meet strict weight ratings to ensure quality and durability. Benches typically come standard with adjustable leveling feet to ensure stability even on uneven surfaces. Caster feet are also a common option giving your lab bench additional mobility.

Storage and Organization:

Laboratory benches often include storage options like drawers, cabinets, or shelves to keep equipment, glassware, and chemicals organized and within reach. This helps in maintaining a clutter-free workspace making them a great tool when designing a lab space . Hanging base cabinets or mobile base cabinets are often used on or around these systems to supplement the workspace with additional storage. Corrosives and Acid Cabinets can also be integrated into the design to sit next to or under bench systems. Shelving units are often built into the benches as an option and will typically come one, two, or three shelf configurations.

Flexibility and Modularity:

Most laboratory bench systems are designed to be modular, allowing you to configure and reconfigure them as needed to accommodate changing research requirements. This adaptability is particularly useful in dynamic research environments. Shelving systems, mobile base cabinets and hanging base cabinet options give you the ability to adapt the furniture as needed. iQ Labs Infinity Bench System allows you to configure the bench as single sided or “shared frame” (double-sided) to better suit your space.

Electrical and Data Connectivity:

Depending on the laboratory’s needs, benches may have built-in electrical outlets, data ports, and cable management systems for powering and connecting various devices and instruments. Power is presented as duplex or GFI receptacles and can be wired as a single or multiple circuit.

Benches can be plumbed to accept various services. Typical services will be vacuum, compressed air, and gas. Services are plumbed out the top of the bench, often terminating to a ceiling service panel with a quick disconnect fitting. These services allow researchers to carry out a broad range of experiments and procedures at each bench location.

Compliance with Standards:

Ensure that the laboratory bench system complies with relevant safety and regulatory standards, such as those established by organizations like OSHA (Occupational Safety and Health Administration) and ANSI (American National Standards Institute). iQ Labs bench and table systems are UL Listed and SEFA approved to ensure the highest level of quality.

Durability:

The bench should be built to withstand the rigors of a laboratory environment, including potential exposure to corrosive substances, frequent cleaning, and heavy usage. iQ Labs Infinity Bench System is built using heavy duty 14ga steel tubing and is coated with our chemical resistant epoxy powder coat.

**Cost and Budget:** Laboratory bench systems are available in a wide range of prices, so it’s important to consider your budget and cost constraints while choosing a suitable system. Additional features such as power, data and plumbing will greatly affect the price of a laboratory bench. Closely considering these features will help you avoid specifying a system that does not meet the needs of your lab.

  Conclusion:

In conclusion, laboratory work benches are indispensable tools for scientific progress. Selecting the right type of bench and optimizing your laboratory space can significantly enhance productivity, safety, and the overall research experience. By following these guidelines, you can create a laboratory environment that fosters innovation and discovery, setting the stage for groundbreaking scientific achievements.

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The Researcher Workbench is a cloud-based platform where registered researchers can access Registered and Controlled Tier data. Its powerful tools support data analysis and collaboration. Data are curated into three datasets and are available for researchers through  All of Us  Research Hub and  All of Us  Researcher Workbench. 

The Research Hub

The Research Hub is public information. Users will need to register in order to gain access to the data and tools in the Researcher Workbench. 

Research Projects Directory

The Research Projects Directory includes information about all projects that currently exist in the Researcher Workbench to help provide transparency about how the Workbench is being used. 

Publications

All Publications using  All of Us  data are featured within the Research Hub and can be found under the discover tab. 

How to Get Started with Researcher Workbench

Researcher Workbench Tools

Powerful tools in the Researcher Workbench support data analysis and collaboration. These tools include: 

• Shared Workspaces to access, store, and analyze data 
• Notebooks capable of high-powered queries and analysis using R or Python
• A Dataset Builder to search and save collections of health information about cohorts 
• A Cohort Builder that allows researchers to create, review, and annotate groups of participant data

Data Curation Process 

More information about the curation process can be found here .

Access Tiers

There are three tiers of data: public, registered, and controlled. Your access to these tiers depends on the Data Use Registration Agreement (DURA) your institution has with the  All of Us  Research Program. University of Illinois Chicago has access to all three tiers. 

The Public Tier 

The Public Tier data contain only aggregate data with identifiers removed and are available using Data Snapshots and the Data Browser . This tier is available regardless of registration status. 

The Registered Tier

The Registered Tier data contain individual level data from Electronic Health Records (EHRs), wearables, and surveys, as well as physical measurements taken at the time of participant enrollment. 

The Controlled Tier 

In addition to the data in the Registered Tier, the Controlled Tier dataset contains genomic data in the form of whole genome sequencing (WGS) and genotyping arrays, previously suppressed demographic data fields from EHRs and surveys, and unshifted dates of events. 

More Information on Data Tiers

Learn more about data tiers by watching All of Us Data Tiers 101  and following along with the slide deck . 

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