phd or md phd

• PhD vs MD – Differences explained
• Types of Doctorates

A MD is a Doctor of Medicine, whilst a PhD is a Doctor of Philosophy. A MD program focuses on the application of medicine to diagnose and treat patients. A PhD program research focuses on research (in any field) to expand knowledge.

Introduction

This article will outline the key differences between a MD and a PhD. If you are unsure of which degree is suitable for you, then read on to find out the focuses and typical career paths of both. Please note this article has been written for the perspective of a US audience.

What is a MD?

MD (also seen stylized as M.D and M.D.) comes from the Latin term Medicīnae Doctor and denotes a Doctor of Medicine.

MDs practice allopathic medicine (they use modern medicine to treat symptoms and diseases). A common example would be your physician, though there are numerous types of medical doctors, with different areas of speciality and as such may be referred to differently.

What is a PhD?

A PhD (sometimes seen stylized as Ph.D.) comes from the Latin term Philosophiae Doctor and denotes a Doctor of Philosophy.

A PhD can be awarded for carrying out original research in any field, not just medicine. In comparison to an MD, a PhD in a Medicinal field is focused on finding out new knowledge, as opposed to applying current knowledge.

A PhD in Medicine therefore does not require you to attend medical school or complete a residency program. Instead, you are required to produce a thesis (which summarizes your research findings) and defend your work in an oral examination.

What is the difference between a MD and a PhD?

Both are Doctoral Degrees, and someone with either degree can be referred to as a doctor. But for clarity, MDs are awarded to those with expertise in practicing medicine and are therefore more likely to be found in clinical environments. PhDs are awarded to researchers, and are therefore more likely to be found in academic environments.

This does not mean that MDs cannot pursue a research career, nor does it mean that a PhD cannot pursue clinical practice. It does mean, however, that PhDs are more suited to those who would wish to pursue a career in research, and that MDs are more suited to those who prefer the clinical aspects of medicine or aspire to become a practicing physician.

It should also be noted that a medical PhD doctorates possess transferable skills which make them desirable to various employers. Their familiarity with the scientific method and research experience makes them well suited to industry work beyond medical research.

Program structure and time

The standard MD program structure sees students undertake 2 years of coursework and classroom-based learning, before undertaking 2 years of rotational work in a clinical environment (such as a hospital). Getting an MD requires attending a medical school (accredited by the Liaison Committee on Medical Education) and completing a residency program. Both of which prepare students to diagnose patients and practice clinical medicine.

The standard PhD program lasts 5 to 7 years and sees students undertake original research (monitored by a supervisor). Getting a PhD requires the contribution of novel findings, which leads to the advancement of knowledge within your field of research. With the exception of some clinical PhDs, a PhD alone is not enough to be able to prescribe medicine.

PhD doctorates are required to summarize the purpose, methodology, findings and significance of their research in a thesis. The final step is the ‘ Viva Voce ’ where the student must defend their thesis to a panel of examiners.

To summarize, a MD program usually lasts 4 years, whilst a PhD program lasts 5 to 7 years. Before being licensed to practice medicine, however, you must first complete a residency program which can last between 3 to 7 years.

What is a MD/PhD?

A MD/PhD is a dual doctoral degree. The program alternates between clinical focused learning and research focused work. This is ideal for those who are interested in both aspects of medicine. According to the Association of American Medical Colleges, an estimated 600 students matriculate into MD-PhD programs each year .

The typical length of a MD/PhD program is 7 to 8 years, almost twice the length of a MD alone. As with a MD, MD/PhDs are still required to attend medical school and must complete a residency program before being able to practice medicine.

In comparison to PhD and MD programs, MD/PhD positions in the United States are scarce and consequently more competitive. The tuition fees for MD/PhD positions are typically much lower than MD and PhD positions are sometimes waived completely.

Those who possess a MD/PhD are commonly referred to as medical scientists. The ability to combine their medical knowledge with research skills enables MD/PhDs to work in a wide range of positions from academia to industrial research.

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MD-PhD, Combined Degree

School of medicine, md - phd, combined degree program.

From its inception, the physician-scientist has been a hallmark of Johns Hopkins medicine and the Johns Hopkins School of Medicine. Indeed, the Hopkins tri-emblem represents the three core values of the institution: teaching, patient care, and research.

The Johns Hopkins School of Medicine offers a variety of opportunities for the training of medical scientists. A combined curriculum leading to both MD and PhD degrees enables students who aspire to careers in academic medicine to obtain intensive training in specialized areas of the biomedical sciences in addition to top-flight medical training. The traditional diversity and flexibility of the educational opportunities at Johns Hopkins permit the design of individualized programs to meet the needs of students with a variety of interests, educational backgrounds, and career goals.

To accomplish our training goals, we expect students to fully commit to medical training while in medical school and research training while in graduate school.  However, we also take important steps to ensure that students are exposed to the intersection of both worlds early in their training, as well as given the professional and career development advice they need to succeed.

In a word, the MD-PhD curriculum at Johns Hopkins is flexible. Most students decide to complete the first two years of medical school before they begin graduate school and finish the last two years of their medical training after completing their thesis work (see the Timeline below). However, students who want more first-hand experience in clinical medicine before beginning graduate work can elect to complete three years of medical school, followed by their graduate training, and then the last year of medical school. This can give them a better appreciation of the potential clinical relevance of their research. In making a choice, trainees consult extensively with the Program Director, the Dean of Students, members of the MD-PhD Committee, prospective research mentors, and their faculty advisors. Students in the MD-PhD Program are automatically accepted to all graduate programs, so decisions regarding graduate training programs can be made with a strong understanding of each program.  The MD-PhD Committee is responsible for program oversight, admissions, and  student mentorship .  Students complete MD-PhD training on average in eight years.

Johns Hopkins interdisciplinary organizational structure means each faculty member may be affiliated with several clinical departments, research sections, and graduate programs. 

Formal graduate programs in the School of Medicine encompass the following areas: Biochemistry; Cellular, and Molecular Biology; Biological Chemistry; Biomedical Engineering; Molecular Biophysics; Functional Anatomy and Human Evolutionary Studies; Cell Biology; Cellular and Molecular Medicine; History of Medicine; Human Genetics; Immunology; Neuroscience; Pathobiology; Pharmacology and Molecular Sciences, and Cellular and Molecular Physiology. Students are also eligible to obtain their PhD in one of the 11 graduate programs at the Bloomberg School of Public Health or the School of Arts and Sciences on the Homewood Campus.  Students may select a thesis mentor from faculty in the Schools of Medicine and Public Health.

The MD-PhD Program also sponsors special seminars and lectures, It also maintains a dedicated library, the Paul Talalay MD-PhD Library, to enrich the educational opportunities of all MD-PhD students. Efforts are made to acquaint MD-PhD candidates with the major advances, concepts, and cutting-edge techniques in contemporary medicine and biomedical sciences.  We also create an environment that promotes a more intimate personal contact with successful medical scientists in this institution.

Admission Procedures.  Individuals who wish to apply for admission to the combined MD-PhD Program of the School of Medicine must submit an application through AMCAS  in which they will indicate the MD-PhD Program.  Once the AMCAS application has been verified and submitted to Hopkins, the applicant will receive an invitation to complete the Hopkins Secondary Application.  Here the applicant will submit the additional materials required for the combined degree.  Johns Hopkins does not allow applicants to apply to both the traditional MD program and the combined program during the same cycle.   

All combined-degree applications are reviewed by a separate  MD-PhD Review Committee  which is comprised of faculty from the basic sciences and clinical arena, as well as faculty from the Bloomberg School of Public Health.  A separate Graduate School application is  not necessary . The MD-PhD Committee determines whether or not an interview is indicated.  In general, the committee is looking for students with a passion for research and a commitment to medicine.  This assessment is based on the applicant’s research experience, letters of recommendation, academic performance and extracurricular activities. The Committee considers standardized test scores only in the context of the applicant’s other credentials. If an interview is granted, the applicant is notified by the MD-PhD Office and after the applicant accepts, the process for scheduling an interview begins.  Interview visits generally occur over two days. Applicants are interviewed by members of the MD-PhD Committee and other faculty members who share their research interests. Applicants have many opportunities to meet with current students and tour the campus during their visit. 

All eligible applicants who are admitted to the MD-PhD Program are funded by the NIH Medical Scientist Training Program (MSTP) Award.  This program, supported by the National Institutes of Health, provides full tuition, stipend, and medical and dental insurance for students. Due to federal restrictions, only U.S. citizens and permanent residents are eligible for MSTP funding.  Approximately 10-12 MD-PhD students matriculate each year.

Students who matriculate to the traditional MD Program but have a clearly demonstrated interest and experience in scientific research, are eligible to apply to the combined MD-PhD Program.  These students may apply for admission during the fall of their first or second year of medical school.  These qualified applicants are evaluated and placed in the pool for the current application cycle and will be considered for MSTP funding.  

Financial Support.  The Johns Hopkins School of Medicine Medical Scientist Training Program (MSTP) is supported by a training grant from the National Institutes of Health. A number of exceptional students with unusual accomplishments and commitment to a career in the medical sciences will be selected for traineeships under this program. Such fellowships provide stipend and tuition support for combined medical and graduate study. All students who are admitted to the MD-PhD Program will be considered for these awards. 

Graduates of The Johns Hopkins University School of Medicine MD-PhD Program have gone on to become leaders in many areas of academic medicine.

Advice on the scope and opportunities offered by these programs may be obtained from the Director or Administrative Director of the MD-PhD Program.

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M.D. vs. PhD. Degrees: What Are the Differences? 

Cait Williams is a Content Writer at Scholarships360. Cait recently graduated from Ohio University with a degree in Journalism and Strategic Communications. During her time at OU, was active in the outdoor recreation community.

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Chances are, when you hear PhD and MD, you at least know that there is a difference between them. Since both are the titles of doctors, there’s still a lot of ambiguity as to what those specific differences are. In this article, we will look at how MDs and PhDs differ from one another and which one might be a better fit for you. Let’s jump in!  

Doctor of Medicine (MD)  

We’ll start by taking a separate look at MDs. An MD is a medical doctor. Their primary job is to work with patients in a variety of settings such as hospitals, clinics, and a variety of other places where having medical staff is necessary. 

School  

In order to become an MD, students must complete their undergraduate degree and then attend a four year medical school. Medical School is then followed by a residency, where a new doctor completes training under a senior physician. From start to finish, becoming a doctor takes around 8-12 years to finish undergrad, medical school, and residency.  

Area of study  

As a medical doctor, you will generally choose one area of medicine that you would like to focus on. Specialties can be based on a certain part of the body, such as cardiology, podiatry, or neurology. Aspiring medical doctors can also specialize in working with a select group of people, such as geriatrics or pediatrics, or finally, you can specialize in researching things like oncology. The possibilities are plentiful for MDs! 

Where they work  

Where you work will depend on what you choose to specialize in. Again, this could be in a hospital, a smaller clinic, or even across the globe with various organizations that work to provide medical care to underserved populations. Medical expertise is needed in many capacities, meaning that there is never a shortage of places that a medical degree could take you! 

A word about DOs  

Before we move on to PhDs, we have one more thing to clear up that you might have questions about. In addition to MDs, there is also another type of doctor called a DO, or a doctor of osteopathic medicine . DOs perform largely all the same functions as MDs, but with a more holistic approach. They attend undergrad just like MDs and then attend a four year DO program that is structured very similarly to a regular medical school.  

The only difference between these two is where they receive their medical school training and how they approach studying medicine and treating patients. If you are thinking about becoming a medical doctor, you should take some time to explore DOs and what they do!  

Doctorate of philosophy (PhD)  

Okay, now onto PhDs! A doctorate of philosophy, known also as a PhD , doesn’t actually have anything to do with philosophy in most cases. A PhD can be completed in pretty much any field and is the highest level of education that one can receive.  

In order to complete your PhD, you will need to first complete your undergrad, then a master’s program, and finally apply to PhD programs. Not all PhD programs require that you finish your masters. There are some schools that offer programs that allow you to complete both your masters and your doctorate at the same time.  

Generally, schooling for your PhD takes anywhere from four to eight years to complete. The first year or two of your PhD is spent on coursework, while the remaining years are spent doing research and completing your dissertation.  

There are endless areas of study that offer PhD programs. You can study everything from physical therapy, business management and psychology to health administration, engineering, social work, and so much more. The gist is pretty much that if you can think of a field of study, you can earn your PhD in it!  

Based on the examples of fields you can study, it’s safe to say that what you study will determine where you decide to work. PhD holders are highly educated people, meaning that finding a job when you hold a PhD in your field will look pretty good to most employers.  

Common places where you find a high concentration of PhDs are in hospitals, corporate offices, college campuses, and other educational institutions. Remember, though, that’s not a full list of where you could work–the list of places you could work is endless! 

Tuition and Costs  

It’s true, pursuing either one of these degrees is not the cheapest thing, but don’t let numbers scare you off! If anything in this article sounds like it is right for you, explore it thoroughly. There are lots of ways that you can pay for your education, including scholarships, organizations, and programs out there that want to help you do it!

Okay, so for some real talk, the price of either of these degrees can vary a lot. Medical school will generally cost between $45,000 – $65,000 a year, while PhD programs cost on average about $30,000 a year. But, again, this does not mean you have to be able to pay these costs out of pocket. There are a lot of programs for PhDs that work with you to help you pay for some of the costs. There are even some fully funded PhD programs !

Similarly, there are tons of medical scholarships and even tuition free medical schools that you can apply to help offset the costs of a medical degree. There are also options for student loans that you can take out as well. The point is, there are tons of ways to find your education. If a degree like this is right for you, it is possible to achieve with proper planning and determination.

Related: Top scholarships for graduate students

Shadowing  

Before jumping all the way in with either of these degrees, shadowing is a great tool that can help you explore your intended field or job. It’s highly encouraged that students who want to attend medical school shadow at least a few different MDs and DOs prior to applying to medical school.  

But the benefits of shadowing are not just for the medical world. You can ask to shadow just about anyone . Maybe you’d like to shadow a professor who you had during undergrad, a social worker, or someone you know of who works in business. There are no rules about who you can and can’t shadow, you simply have to ask and go from there!  

What is right for you  

Below are some basic questions to help you get your mind started thinking about whether an MD or PhD is right for you. The first set of questions pertains more to MD or DO degrees.  

If you’re thinking about an MD or DO degree…  

Questions to consider.

• Do you like working with people and helping them during difficult times?  
• Do you love studying biological sciences ?  
• Does working in a hospital or clinic sound like an environment you would enjoy? 

If you’re thinking about a PhD…  

• Is there a specific area or field you would like to study? 
• Do you have a specific job in mind that you would like, and does it require a PhD? 

The answers to these questions won’t instantly help you decide, but they should help you think a little deeper about these degrees. 

Key Takeaways

• Both MDs and PhD holders are highly educated in their field of study, holding the highest degrees that you can earn 
• The only way to become a practicing MD is to first obtain your bachelor’s degree, then attended a four year accredited medical school, and then successfully complete all the proper exams to practice medicine 
• To earn a PhD, you do not have to attend medical school, but you will need to attend a PhD program, complete your undergrad, and usually complete your master’s degree before doing so 
• There are lots of ways to fund both a PhD and an MD, including scholarships, grants, loans, and partially and fully funded programs for each 

Frequently asked questions about the differences between MD and PhDs  

Is a phd higher than an md, who gets paid more an md or a phd, is a phd harder than an md, scholarships360 recommended.

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If you can’t imagine a medical career without helping patients and participating in research, you’ve probably considered the MD-PhD track. Learn all about applying to MD-PhD programs and get our expert tips for strengthening your application.

Is an MD-PhD Program right for you?

The MD-PhD is a dual doctorate degree program for students who are interested in careers as “physician-scientists." By graduation, you’ll have fulfilled requirements for both the MD and PhD degrees. The MD-PhD takes about 8 years to complete during which you receive medical training AND become an expert in a specific research field. The program also requires dissertation research in your field of graduate study, which can range from biomedical laboratory disciplines like biochemistry or genetics to fields like economics, sociology, or anthropology . After graduation, MD-PhD students usually work as researchers or as faculty members at medical schools and universities.

Learn more about MD combined degree programs .

What are Medical Scientist Training Programs?

Medical Scientist Training Programs (MSTP) are MD-PhD programs that are funded by the National Institute of Health. Students who are admitted to these highly-competitive programs receive full tuition coverage, living expenses, and a stipend. There are currently 45  NIH-funded MSTP programs .

Are all MD-PhD programs free?

Over 60 medical and osteopathic medical schools  maintain their own MD-PhD or DO-PhD programs that are not funded by the NIH. Depending on the school, these programs offer full or partial financial support for their students.

Applying to MD-PhD Programs

Nearly all MD-PhD programs use the same application process as MD admissions—via the American Medical College Application Service (AMCAS) application . One key difference? MD-PhD applicants submit two additional essays: the MD-PhD Essay and the Significant Research Experience Essay:

• The MD-PhD Essay asks you to explain your reasons for pursuing the combined degree program.
• The  Significant Research Experience Essay asks you to describe your key research experiences, including your research supervisor's name and affiliation, the duration of the experience, the nature of the problem studied, and your contributions to the project.

Read More: Guide to Your Med School Applications

Do you need to take the GRE Test to apply for the Md-Phd Program?

Programs have different policies, so some schools may require both the MCAT and the GRE for combined degree applicants. For example, an MD-Phd in Anthropology at one school may require the GRE, while the MD-PhD in Immunology may not. Check with your prospective med schools to make sure you’re covered.

Timeline for MD-PhD Admissions

The MD-PHD application timeline is virtually the same as for MD admissions. (Remember you are using the same application service!) Here are the important dates for MD-PHD admissions:

• Early May: AMCAS opens and begins accepting transcripts
• Early June:  AMCAS begins accepting application submissions
• October–March: MD-PhD applicant interviews
• December–March: Admissions decisions sent to applicants
• March–April: Md-PhD applicants make their final decisions
• June–August: MD-PHD programs begin!

Tips for Boosting Your Md-Phd Application

Competition for MD-PhD applicants is fierce. After all, you have to convince medical schools to invest significant time and financial resources in you. Of the total 1,936 MD-PhD applicants in 2016–17, only 649 matriculated in a U.S. med school. Here’s what you can do to strengthen your overall application.

1. You need strong MCAT scores and a high GPA

If your grades and scores aren’t where they need to be, address it before you apply!  Check out these admissions stats for MD-PhD matriculants to U.S. medical schools from 2016-2017:

SOURCE:  Association of American Medical Colleges

Make a smart MCAT prep plan and retake the exam if necessary. Consider completing additional grad school work to raise your GPA and take advantage of our online tutors for pre-med requirements!

2. You need sustained research background + a clear picture of your future in research

3. you need the right recommenders.

Most letters of recommendation should come for your research mentors, professors who run the labs you work in, and the postdoctoral fellows you work with. Make sure your recommenders know that you are applying to MD-PhD programs as this will affect the letters they write.

Want to get an edge over the crowd?

Our admissions experts know what it takes it get into med school. Get the customized strategy and guidance you need to help achieve your goals.

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MD PhD vs MD: Which is best for you?

If you find yourself struggling between pursuing an MD PhD vs MD degree, you've come to the right place. In this blog, we'll explore the similarities and differences between medical doctors and physician-scientists to help you determine how to choose the pathway that is best suited for you.

>> Want us to help you get accepted? Schedule a free strategy call here . <<

Article Contents 7 min read

Md phd vs md: education.

While those with MD PhD and MD degrees are both medical doctors, MD PhD graduates also possess a PhD and are therefore known as physician-scientists or medical scientists. Obtaining this extra degree requires a different program structure and length compared to MD programs. MD PhD programs are generally 7-8 years in length and require attendance at both medical and graduate school. MD programs, on the other hand, will be completed in four years, half the time it will take MD PhD students. While both programs are classroom-based during the first two years, MD PhD students will move on to graduate school to complete their PhD thesis for between 3-4 years. They will then return to medical school for a year or two completing clinical rotations. Both MD PhD and MD graduates will complete their residency training for between 3-7 years before being licensed to practice medicine.

MD PhD vs MD: Application and Tuition

Whether you're interested in an MD PhD or an MD program, the application process is similar. You'll apply to most programs through AMCAS where you'll complete all sections of the application including the AMCAS work and activities section and you'll upload your coursework, letters of evaluation, and medical school personal statement . Make sure to find out if the schools of your choice require you to take CASPer test. If so, start practicing using CASPer sample questions as soon as you can. In addition to the standard application components, MD PhD applicants will have to complete two additional essays that describe both their reasons for pursuing an MD PhD degree and their research experience. Review our medical school application timelines  blog to ensure you're aware of the application process and corresponding deadlines.

It's no secret that both MD PhD and MD programs are extremely competitive, with acceptance rates on average between 1-4%. There are far fewer MD PhD programs available compared with MD programs and the large benefit of reduced or waived tuition makes for even higher competition, especially in MSTPs vs MD programs. It's a good idea to use our medical school chance predictor to see how your grades and test scores compare with the average scores of accepted individuals into either program. Last year, MD PhD matriculants had an average MCAT score of 516 and an average GPA of 3.80 compared with the 511.5 MCAT score and 3.73 GPA of MD matriculants. So, we can see that in order to be a competitive MD PhD applicant, you'll have to possess a higher GPA and MCAT score than if you were to apply as an MD applicant. Of course, the level of competition varies between schools, and there are certainly MD programs that receive a high volume of applicants competing for few spots making some MD programs more competitive than MD-PhD programs, it's entirely dependant on the school, program, and application cycle.

MD PhD vs MD: Career Outlook and Salary

Although it may seem obvious that students who graduate from MD programs become medical doctors and most practice medicine at hospitals, clinics, medical centers, and private practices, some students are unsure of what a career looks like as a physician-scientist. Many MD PhD graduates choose to complete their residency training in internal medicine, pathology, pediatrics, and neurology, however, many other specialties are also represented, from surgery to radiology to emergency medicine. Internal medicine is also a common specialty choice for MD graduates as well as pediatrics, emergency medicine, and family medicine. According to a study conducted by the AAMC, nearly 80% of all MD PhD graduates enjoy careers as faculty members at medical schools or work for the National Institute of Health (NIH), other research institutions, industry, and federal agencies with many devoting a large portion of their time to research. Also, out of roughly 7000 MD-PhD alumni that took part in this study, 82% said that they would partake in MD-PhD training again, even if they had the chance to go back in time and change their mind.

Physician-scientists not only possess in-depth knowledge in the medical field, they also have knowledge of population health and disease and will be trained to conduct independent research and analysis. With this dual degree, physician-scientists are highly valued for their ability to treat patients while also contributing to detecting health threats, developing new treatments, therapies or even cures. Physician-scientists working in academia can teach and provide clinical service, while also conducting their own, or joint, research. The annual salary for physician-scientists is usually between $60,000-$115,000, depending on the type and place of employment.

Physicians manage and support the health and well-being of those in their care. Through physical examinations, diagnostic testing, treatment, and communication, they can manage and significantly improve the health of their patients. Depending on the type of physician, they may perform surgeries and treat either general or specific illness and disease. Annual salaries generally correspond to level of training and specialization and usually range from $180,000-$280,000

For some, from the moment they put on safety glasses in science class or that time they resuscitate their childhood teddy bear, they knew what they were going to be when they grew up. Not everyone has an immediate passion or the typical “aha” moment later on in life. Sometimes, a student's drive to medicine or research develops later on in life, through experiences, education or even while overcoming hardships, and this is perfectly normal. So, what if you have a passion for both science and medicine? How can you choose whether to pursue an MD degree or a joint MD PhD degree? It's important to choose only once you've considered a variety of factors and are 100% sure in your decision, because the reality is, neither option will be easy and you'll have to be willing to invest the time, money, and effort to be successful.

Find out what drives you.

Start by thinking about what you're interested in and what motivates you to help you determine where your true passions lie. If you know that you are really interested in medicine and in helping others but only have a slight interest in research, then it's probably a good idea to pursue medicine on its own. At nearly twice the length of an MD program, the MD PhD program is no walk in the park. Students should only pursue this joint degree if they have a serious passion for both medicine and research. In addition to feeling passionate about treating patients, if you find yourself interested in the mechanisms behind disease, are curious about the unknowns and can't picture a career that doesn't involve research, it's a good sign that the joint program will be suitable for you.

Determining whether or not you are interested in becoming a medical doctor or a physician-scientist is the first and most important decision you'll have to make when deciding between the two pathways. If you're motivated by your passions, you're likely to enjoy your career because it's actually what you want to do. By putting in the time and effort to be the best version of yourself, you'll have a fulfilling rewarding career.

So, how can you know for sure which path is the best for you? Gain experience in the field well in advance of filling out your applications. This will be closest you'll get to test drive your potential career choice. If you're struggling to decide between an MD and MD PhD program, be sure to gain both clinical and research experience. This will be a great way for you to get hands-on experience in both fields to see which areas really spark your interest and which areas you're not as keen on. Learn how to ask to shadow a doctor , sign up for volunteering experiences that place you in the medical or research field, and partake in scientific experiments where you'll be testing hypotheses to gain research experience. Not only will these experiences be essential when filling out your medical school applications, the key is that through a variety of different experiences, you'll be able to hone in on your interests.

Consider the affordability of each program.

According to the AAMC, approximately 76% of medical school students graduate with debt. For the students that borrow money, the median debt is approximately $200,000 at public medical schools. Of course, with an average physician salary of $300,000, this debt can be repaid, but it can be a rocky start for students as they begin entering their careers. A major benefit of MD PhD programs is the fact that most programs partially cover or completely waive tuition for enrolled students, and many also provide a stipend that can be used to cover the costs of living expenses. Due to this, some students can finish their training debt-free, and potentially even with a decent amount of savings. Now, this isn't to say that you should simply pick a program based on the cost but it's an important factor to consider if you want to pursue either option. What's important is that you pick your path depending on which best aligns with your interests, motivations, and short and long term career goals.

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Message From the Chair

A message from Ali G. Gharavi, MD, Interim Chair for the Department of Medicine at CUIMC.

Residencies, Fellowships & Training

A list of residencies, fellowships, and training programs of Columbia University Department of Medicine. 

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Department of Medicine

3-year phd-to-md program.

We seek to recruit exceptional PhD scientists in the biological sciences for a 3-year curriculum in the Vagelos College of Physicians & Surgeons leading to the MD degree, in preparation for a career in biomedical investigation.

Success in basic science often follows the cliché that one learns more and more about less and less. Thus PhD training is notable for its narrow focus. However, for committed scientists who want to make an impact on humanity, a medical education is an ideal companion to one in basic science as it combines breadth and depth like no individual discipline in biology. Humans remain the best-studied organisms we have, the ultimate “model organism,” with phenotypes exquisitely characterized by millennia of study through the unique interaction of two classes of sentient beings, physicians and patients. Moreover, learning to recognize and treat disease teaches that most cardinal attribute of a successful scientist: the capacity to ask important questions. Standard MD-PhD programs (MST programs) share this aspiration to nurture biomedical investigators but less than 50% of MST graduates remain in research with a much smaller percentage contributing as serious investigators. We are looking for candidates who were drawn initially to science, have a potential for research already tested and proven by stellar performance in a PhD program, and are excited by their discoveries in basic research, but who now feel compelled to use their science most directly for the betterment of mankind.

Candidate Qualifications

In addition to existing prerequisites and qualifications for admission to the Vagelos College of Physicians and Surgeons (See  Application Requirements ), applicants should have

• A PhD in one of the biological or related sciences from an accredited US or Canadian school
• An intention to pursue biomedical research as a physician scientist
• A record supporting exceptional scientific promise
• US citizenship or permanent resident status

The 3-year program principally aims to train future physician scientists planning careers in cognitive medical specialties such as internal medicine, pediatrics, neurology, psychiatry and pathology.  

Curriculum and Timeline

The usual 4-year curriculum of the Vagelos College of Physicians and Surgeons (See  Academics ) is modified to the following 3-year curriculum for the PhD-to-MD Program:          

• Preclinical courses: 18 Months
• Major clinical year (MCY): 12 Months
• Subinternship and electives: 6 Months

See Detailed Graphic

The scholarly project requirement is waived. Students will apply for residency in the middle of the MCY. Of note, the medical training for the PhD-to-MD Program is identical to the medical training for our standard MD/PhD (MST) program.  

Standard tuition for each of the 3 years. Comprehensive information on financial aid opportunities is available (see  Tuition and Expenses ).

Application Process, Selection Criteria, Interview Day

Applicants will be evaluated by the same criteria applied to all candidates for admission, and will be reviewed and selected by the existing Admissions Committee. An additional committee representing the PhD-to-MD program will evaluate, interview and recommend candidates to the Admissions Committee. This supplemental committee will focus on the scientific achievement, research promise and commitment of the applicant to a career as a physician-scientist. Applicants to the PhD-to-MD degree program invited to interview will be asked to submit their curriculum vitae and a one-page research proposal.  

Please see the  3-year FAQs , or contact the admissions office at  [email protected] .

PhD vs MD vs MD PhD – What’s right for you?

• Cracking Med School Admissions Team

For some students, choosing between a career in medicine and one in science seems like an impossible task. Many times, students will engage in research during college and develop an interest in medicine and do not want to give up the ability to do both by pursuing either a PhD or MD. Recognizing this desire, many medical schools have also created MD-PhD combined programs that allow students to get both degrees. With the plethora of options offered for graduate degrees coming out of college, many applicants are unsure of which program is best for them.

In this blog post, we will cover the following topics:

• PhD vs MD vs MD PhD?

What are the differences between PhD vs MD?

• MD vs MD PhD – which is right for a future doctor?
• Pros and Cons of MD PhD
• Complete List of MSTP Programs
• Resources for future MD PhD Applicants

Our Students Were Accepted at These MD PhD Programs!

PhD vs MD vs MD PhD

Before we analyze the differences between these programs, we will clearly define what each program consists of.

What is a PhD? PhD programs are funded graduate doctoral degree programs ranging from 4-8 years offered by research universities to teach and mentor graduates to contribute to research in their field, develop societal solutions, and train the next generation of scientists.

What is an MD? MD degrees are granted by allopathic medical schools in the United States, last four years, and prepare graduates to enter the world of medicine as physicians, usually through continued training in residency and fellowship programs.

What is an MD PhD program? MD/PhD programs are funded programs that last 7-9 years and train graduates to be clinical and academic leaders as both physicians and researchers who work closely with patients but also dedicate a significant amount of their time to researching areas adjacent to medicine to improve knowledge and treatment protocols.

When deciding PhD vs MD vs MD PhD, most students will first need to decide what aspects of science are most interesting to them – do they enjoy the interpersonal interactions or working with the biology itself to make new discoveries? First, let’s look at the differences between a PhD vs MD. There are three core differences between getting a PhD and an MD: career opportunities, admissions and training, and cost.

Career Options

As rigorous and prestigious degree programs, both MDs and PhDs have a plethora of career opportunities available to them. Most graduates from MD programs elected to continue their training by completing a residency and fellowship to become specialized and practice medicine. Nonetheless some graduates also choose to pursue alternative careers in public health, business, or education. In fact, 32% of graduates from Stanford’s MD program [1] chose not to a pursue a residency, many drawn by the allure of alternative ways to produce impact in society.

PhD graduates tend to have slightly more options, in both the academic and professional spheres. Many PhD candidates choose to pursue the established path of joining a research university to perform their research while teaching undergraduate and graduate students. This path often is best suited for those extremely passionate about their research topics who seek to mentor younger researchers and students but suffers from department politics attached to rising up professorial ranks and difficulties in receiving funding in certain disciplines.

Many other graduates choose to pursue non-academic work, whether it is joining an established industry company, starting their own companies, or working in public sector agencies. In these endeavors, they are able to leverage much of their subject matter expertise to conduct research, assess business operations and growth options, and contribute to public health or public works initiatives. At the same time, many graduates who take this path may find themselves drifting away from their academic routes and may find a slightly more fast-paced lifestyle than in academia.

Whether you pursue and MD degree or PhD degree, there are several post-graduate career options. 

Admissions and Training

Admissions and training processes and timelines are also highly variable between MD and PhD paths, and require different planning for each.

MD Admissions and Training: MD programs often have extremely long admissions timelines, often starting two years before matriculation when many students begin studying for the MCAT (the medical school admissions exam). In addition, the increasing expectations of applicants has resulted in an increasing number of students taking gap years to adequately prepare to apply. After applying and matriculating, medical students have four years of medical school, followed by anywhere from 3-10 years of post-graduate specialization training. Furthermore, applications often have multiple components, require in-person interviews, and have delayed decision timelines.

PhD Admissions and Training: In contrast, PhD programs have relatively simpler timelines, with most students applying the winter before they plan to matriculate, with many schools not requiring standardized testing (GRE) to apply. After applying, many students receive interviews within a few weeks and an admissions decision soon after. After matriculating, program length can differ significantly, but usually consists of 5-8 years of graduate research and training before one is able to complete their degree.

Despite recruiting students with similar skillsets and backgrounds, medical school and graduate PhD programs have radically different cost structures. While pursuing an MD is a costly endeavor (often ranging from $200-400k), PhDs are usually fully funded and most students receive a generous living stipend. With this in mind, one would assume that most students would naturally gravitate to a PhD. However, while the median biology PhD starting salary is $100k [2] , the median starting salary for a physician is double – at $200k [2] – such that many physicians recoup the cost of their education in the long term. Although the ultimate decision will depend on your desire to take on loans and your career and training area preferences, cost is undoubtably an important component of this decision as well.

What are the differences between MD vs MD PhD

Differences between MD and MD-PhD admissions are neither widely discussed nor well understood, mostly because only 6-7% of students applying to medical school choose to pursue this path. [4]  

MD-PhD programs are one of many dual-degree programs offered by medical schools and allow you to receive medical training while developing expertise in a particular research area. Your research focus can range from hard science like molecular biology and genetics to the social sciences like sociology. Since you would be getting two degrees, a MD-PhD program is designed to take 7-8 years, instead of 4 years for medical school and 5-6 years for a PhD. Usually, MD-PhD candidates will spend their first two years doing pre-clinical coursework with MD students. After completing their pre-medical requirements and taking the STEP 1 exam, MD-PhD students will usually take 3-5 years for their doctoral studies before they return for their final two years of clinical rotations.

In the United States, there are approximately 130 MD-PhD programs and 45 of these programs are known as Medical Scientist Training Programs (MSTP) programs. MSTP programs are funded by the National Institute of Health (NIH) and are very competitive as they offer full tuition coverage, support with living expenses, and a stipend. While some MD-PhD programs are funded by institutions, many of them may not offer the same financial support as an MSTP program.

Since the key difference between the MD and MD-PhD program is the emphasis on research, make sure that you will be able to demonstrate a longstanding commitment to research and that you have tangibly and significantly contributed to research projects, which can take the form of presentations or serving as an author on papers. Also, make sure that your research mentor is prepared to submit a strong recommendation to attest to your readiness for such a rigorous program.

Only 6-7% of medical school applicants apply as an MD PhD candidate

AMCAS most meaningful activity example #2: This applicant chose to write about his work in the emergency room. You can see both the 700 character AMCAS activity description and the 1325 character AMCAS most meaningful essay.

Pros and Cons of Applying MD PhD

Pros of applying md phd vs md, why md phd #1: tuition funding .

There is no doubting it – medical school is very expensive. Since many MD-PhD programs are fully funded with a living stipend on top, many MD-PhD candidates feel that they are being “paid” to pursue this education. While many of their medical school classmates will graduate with tens or hundreds of thousands of dollars of debt, most MD-PhD candidates will not incur any cost during the course of their degree, attracting many looking to avoid accumulating further debt in addition to whatever was accrued during college. Although this funding seems attractive at first, it is important to remember that it comes at the cost of four more years, which could be time spent earning an attending’s salary. Depending on your choice of specialty, receiving this funding could actually be a negative if you aren’t interested in research.

Why MD PhD #2: Allows you to pursue 2 passions

If you are unable to decide between science and medicine, or want to pursue both, applying to an MD-PhD program will allow you to bridge these two disciplines and enjoy the best of both worlds. Many MD-PhD candidates believe that their professional careers would be incomplete without both research and medicine or seek to combine these two passions in their career. These are the exact candidates that MD-PhD programs exist for as they open up many opportunities that may not be available for regular MD students. Especially if you hope to have a career in academia or research-based medical universities, the skills and competencies of doing research and applying for grants is highly prized.

Why MD PhD #3: Receive great research and medical training in a shorter time period

It is undeniable that the condensed time frame of the MD-PhD program is highly appealing to those who seek to pursue both degrees. Instead of taking 9-10 years if completed separately, an MD-PhD program is highly integrated and structured to allow you to focus on one pursuit at a time while still providing continuity so that you can do research during your medical training and medical volunteering while completing your doctoral work. This blend allows for the shorter time period and still allows you to benefit from receiving high quality science and medical instruction.

Cons of Applying MD PhD vs MD

Why not apply md phd #1: time to complete degree .

Although the condensed format is ideal for those who have their hearts set on getting both an MD and a PhD, if you are unsure about pursuing both degrees or have a clear preference for one, the significantly longer educational period is a major factor to consider. A major aspect of the admission process for the MD-PhD is determining if you are prepared to make an almost decade-long commitment to a discipline, institution, and city. The projected 7-8 years to complete an MD-PhD is just that – a projection. Many times, there are factors both inside and outside of your control that can cause this number to vary greatly and increase to up to 10 years. Furthermore, since many people start their MD-PhDs at 23 or 24 years old, they often complete their residency in their late 30s, a fundamentally different time of your life where many of your friends from college may already have families and have been in the workforce for over a decade.

Why not apply MD PhD #2: You can still do research without a PhD

Although MD-PhD students learn how to apply for grants and the research skills necessary to drive their future academic careers, many MD students often pick up these skills if they take a research year, pursue a master’s degree, or spend a significant amount of time doing research in residency and beyond. In fact, while many researchers in academic institutions are PhDs or MD-PhDs, there are also numerous MDs who spend a large amount of their time dedicated to both clinical and basic science research. Furthermore, if your research interests are solely clinical in nature, you may be better served developing these skills in a residency or pursuing a master’s degree than pursuing an MD-PhD, which is usually more suited for basic scientists. Another downside to the MD-PhD is that while you will be focused on trying to pursue two separate paths as a clinician and scientists, many of your peers will be spending all of their time focusing on one of the two, which may put you at a disadvantage compared to them.

Why not apply MD PhD #3: May limit specialty choice

Finally, while MD-PhD students can technically pursue any residency after they graduate medical school, there is often a push to place them in less competitive and non-surgical specialties where they will have less clinical time and therefore more time to dedicate to their research work. Since surgical specialties are highly procedural, research is often a secondary consideration and usually not as prized as surgical dexterity. Furthermore, since you are more valuable to an academic center as a surgeon performing high value elective procedures than as a researcher, there is often a push to have surgeons focus on their clinical work. Similarly, many MD-PhDs may be encouraged to pursue less competitive specialties where they have more time to focus on their research work or where their research funding may be more valuable than the money they bring in from being a clinician. Although an MD-PhD student is free to pursue any specialty that they desire, these pressures are commonplace and often can stifle strong clinical preferences in favor of research potential.

List of MSTP Programs

As stated earlier, MSTP MD PhD programs are fully funded by the National Institutes of Health. 

As of 2021, here is the list of MSTP MD PhD programs by state.

University of Alabama at Birmingham School of Medicine http://www.uab.edu/medicine/mstp

Stanford University  http://med.stanford.edu/mstp.html

University of California, Davis School of Veterinary Medicine https://vstp.vetmed.ucdavis.edu/

University of California, Irvine School of Medicine http://www.mstp.uci.edu

University of California, Los Angeles & Cal Tech California Institute of Technology David Geffen School of Medicine http://mstp.healthsciences.ucla.edu

University of California, San Diego School of Medicine http://mstp.ucsd.edu

University of California, San Francisco School of Medicine https://mstp.ucsf.edu/

University of Colorado Denver http://www.ucdenver.edu/academics/colleges/medicalschool/education/degree_programs/mstp/pages/MSTP.aspx

Connecticut

Yale University School of Medicine http://medicine.yale.edu/mdphd

University of Miami Miller School of Medicine http://mdphd.med.miami.edu

Emory University School of Medicine M.D./Ph.D. Program http://med.emory.edu/MDPHD

Northwestern University Medical School http://www.feinberg.northwestern.edu/sites/mstp

University of Chicago Medical Scientist Training Program https://pritzker.uchicago.edu/academics/mstp-landing-page

University of Illinois at Chicago College of Medicine http://chicago.medicine.uic.edu/mstp

Indiana University School of Medicine, MSTP https://medicine.iu.edu/education/dual-degrees/

University of Iowa Carver College of Medicine https://medicine.uiowa.edu/mstp?

Johns Hopkins University School of Medicine https://mdphd.johnshopkins.edu/

University of Maryland School of Medicine http://mdphd.umaryland.edu

Massachusetts

Harvard Medical School/Massachusetts Institute of Technology

There are two MD/PhD programs through Pathways and HST. Read more about Harvard Medical School here:  https://crackingmedadmissions.com/how-to-get-into-harvard-medical-school/ http://www.hms.harvard.edu/md_phd

Tufts University School of Medicine http://sackler.tufts.edu/Academics/MSTP-Welcome

University of Massachusetts Medical School http://umassmed.edu/mdphd

University of Michigan Medical School http://medicine.umich.edu/medschool/education/mdphd-program

University of Minnesota Medical School http://www.med.umn.edu/mdphd

Mayo Medical School https://college.mayo.edu/academics/biomedical-research-training/medical-scientist-training-program-md-phd/

Washington University School of Medicine http://mstp.wustl.edu

Albert Einstein College of Medicine http://www.einstein.yu.edu/education/mstp

Columbia University College of Physicians and Surgeons http://www.cumc.columbia.edu/mdphd

Icahn School of Medicine at Mount Sinai http://icahn.mssm.edu/education/graduate/md-phd-program

New York University School of Medicine http://www.med.nyu.edu/sackler/mdphd-program

Stony Brook University https://medicine.stonybrookmedicine.edu/mstp

University of Rochester School of Medicine and Dentistry http://www.urmc.rochester.edu/education/md/md-phd

Weill Cornell/Rockefeller/Sloan-Kettering Tri-Institutional MD PhD  Program http://weill.cornell.edu/mdphd

North Carolina

Duke University Medical Center https://medschool.duke.edu/education/degree-programs-and-admissions/medical-scientist-training-program

University of North Carolina at Chapel Hill School of Medicine http://www.med.unc.edu/mdphd

Case Western Reserve University School of Medicine http://mstp.cwru.edu

Ohio State University College of Medicine http://medicine.osu.edu/mstp

University of Cincinnati College of Medicine MSTP http://www.med.uc.edu/MSTP

Oregon Health and Science University School of Medicine http://www.ohsu.edu/mdphd

Pennsylvania

Penn State College of Medicine http://www.pennstatehershey.org/web/mdphd

University of Pennsylvania Perelman School of Medicine http://www.med.upenn.edu/mstp

University of Pittsburgh http://www.mdphd.pitt.edu

South Carolina

Medical University of South Carolina https://education.musc.edu/colleges/graduate-studies/academics/dual-degree/mstp

Vanderbilt University School of Medicine MSTP https://medschool.vanderbilt.edu/mstp

Baylor College of Medicine MSTP https://www.bcm.edu/education/programs/md-phd-program

University of Texas Health Science Center Houston Department of Internal Medicine https://gsbs.uth.edu/mdphd/

University of Texas Health Science Center San Antonio Department of Neurology, Pharmacology, and Physiology https://lsom.uthscsa.edu/mimg/

University of Texas Southwestern Medical Center at Dallas https://www.utsouthwestern.edu/

University of Virginia Health System MSTP Program http://mstp.med.virginia.edu

University of Washington School of Medicine http://www.mstp.washington.edu

Medical College of Wisconsin MSTP https://www.mcw.edu/education/medical-scientist-training-program

University of Wisconsin School of Medicine and Public Health http://mstp.med.wisc.edu

Read our medical school profiles to learn more about each individual school. 

Now that we have reviewed what MD, PhD, and MD-PhD degrees consists of and how to apply, as well as some of the pros and cons of pursuing a MD-PhD program, we hope that you can make an informed decision about your graduate education! Even if you choose not to pursue an MD or PhD, many institutions have accelerated programs that allow MD or PhD graduates to complete the other degree in a shorter timeframe. Similarly, many medical schools even allow students to apply to add a PhD portion onto their education before they begin their clinical training. Regardless of whichever path is right for you, all three offer incredible opportunities to pursue scientific passions and work towards solving societal issues.

Here are some Cracking Med School Admissions Resources you will find helpful as you think about MD PhD programs:

• How To Shadow A Doctor
• Resume, CV, and Cover Letter Edits
• Premed Timeline: Planning For Medical School Applications

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Is an MD/PhD program right for me? Advice on becoming a physician–scientist

We are living in a golden age of biomedical research in which it is increasingly feasible to translate fundamental discoveries into new diagnostic and therapeutic approaches to human illnesses. Inherited diseases are being cured with gene therapy. Cancer cells are being eliminated with less toxic small molecule inhibitors and reengineered T-cells. Direct connections are being made between the central nervous system and prosthetic devices. These efforts are being led by scientists and engineers, some of whom are also physicians. This article is intended to help anyone considering a career as a physician–scientist, but unsure about how best to begin. It is also intended for faculty, staff, and parents who are on the front lines of advising talented students about the options that they have for their future. With this in mind, I have tried to answer common questions about MD/PhD programs, but I have also included information about other paths to becoming a physician who does research.

INTRODUCTION

Because this is a perspectives piece, I will begin it with a confession: I have been a physician–scientist for more than 30 years and I like what I do. I am also a graduate of one of the earliest MD/PhD programs and have been director of the University of Pennsylvania’s MD/PhD program for 20 years. Being a physician who is also a scientist already makes me atypical. According to the American Medical Association, only 14,000 U.S. physicians (out of nearly 1 million) consider research to be their major job, and a search of National Institutes of Health (NIH) databases in 2012 turned up only 8200 physicians who were principal investigators on NIH research grants ( Ginsburg et al. , 2014 ). To put that number in context, there were 28,000 total investigators with NIH grants in 2012. In other words, most NIH principal investigators are PhD scientists, not physician–scientists (MD or MD/PhD).

My primary day (and sometimes night and weekend) job as a card-carrying physician–scientist is overseeing an NIH-funded research team. My clinical responsibilities include taking care of patients with the kinds of bleeding and blood clotting disorders that we study in the lab. Some of these patients have medical problems that are common in the United States. Some of them are true “zebras,” the kinds of patients who get referred to a well-respected academic medical center because physicians are unsure how best to proceed or lack the resources to manage the patient’s problem. I also teach medical students and graduate students, and I direct a very large MD/PhD program. In my spare time, I talk to lots of undergraduates and recent college graduates who are thinking about becoming physician–scientists and wondering whether they should be applying to MD/PhD programs. I meet them at Penn, but also on visits to other colleges and universities. This article is a distillation of some answers to questions that I am commonly asked. If you are an undergraduate trying to decide whether to go to medical school, graduate school, or both, this article may help you. Whatever you decide, I wish you success.

WHAT IS THE PURPOSE OF MD/PhD TRAINING?

MD/PhD programs were established in the 1950s to combine training in medicine and research. They were specifically designed for men and women who wanted to become research physicians, also known as physician–investigators or physician–scientists. Most of the graduates of MD/PhD programs in the 60-plus years since then have become faculty members at medical schools and universities, investigators at research institutes such as the NIH, or leaders in in the pharmaceutical and biotech industries ( Brass et al. , 2010 ). Regardless of where they eventually end up, MD/PhD trainees are being prepared for careers in which they will spend most of their time doing research or translating that research into new therapeutic and diagnostic approaches. It is a busy, challenging, and hugely rewarding career. A study of what has happened to MD/PhD program graduates from 24 schools appeared in Academic Medicine in 2010 and is worth reading not only for the data set, but also for the discussion of what the data mean ( Brass et al. , 2010 ). An even larger outcomes study that includes data on over 10,000 MD/PhD program graduates is scheduled for publication as a AAMC report in April 2018 ( Akabas et al. , 2018 ).

HOW CAN ONE PERSON DO TWO JOBS?

When I was an undergraduate and trying to decide what to do with my life, my mentors told me that I could become a doctor or a scientist, but that trying to combine two busy professions was futile. Many years later, I know that many current undergraduates are being told the same thing. However well-meant, that advice misses the point. The goal of MD/PhD program training is not to prepare you for two unrelated full time jobs. Instead, you should think of physician–scientists as chimeras—blends of a physician and a scientist with the two parts fitting closely together. A more relevant question is: if you are going to become a physician–scientist, do you have to go through an MD/PhD program? I will try to answer that one a bit later in this article. First, I’ll provide some definitions.

WHAT IS THE DIFFERENCE BETWEEN AN MD/PhD PROGRAM, A COMBINED DEGREE PROGRAM, AND AN MSTP PROGRAM? A BIT OF HISTORY AND A WORD ABOUT FUNDING

None. Programs designed to train physician–scientists go by all of these names. For the most part, the terms are interchangeable, although at some schools “combined degree” programs can include MD/JD and MD/masters programs as well—also VMD/PhD programs, which train veterinary physician–scientists. A list of MD/PhD programs can be found at http://www.aamc.org/students/research/mdphd/applying_MD/PhD/61570/mdphd_programs.html . The NIH uses the term MSTP (short for “medical scientist training program”) to refer to programs at schools that have been competitively awarded special training funds to help support MD/PhD candidates. There are currently 46 MD/PhD programs that receive support from the National Institute of General Medical Studies. A list can be found at http://www.nigms.nih.gov/Training/InstPredoc/PredocOverview-MSTP.htm .

When they first started, there were only a handful of MD/PhD programs. I can clearly remember reading a small booklet about applying to medical school that had a single page at the back about MD/PhD programs. Over time, the number of programs has grown. Now there are ∼90 active MD/PhD programs that admit anywhere from a few students per year to 25 or more. The average size of an MD/PhD program in 2017 was ∼90 students in all stages of training. Compared with the many thousands who apply to medical school in each year, only 1900 (∼3%) apply to MD/PhD programs. About one-third of the applicants are accepted, which is similar to the acceptance rate for medical school. 1 When I began medical school, there were very few MD/PhD trainees—I was one of two in my entering class. That has changed considerably. There are currently ∼5500 men and women in training in MD/PhD programs.

Most MD/PhD programs provide tuition waivers for both medical school and graduate school plus a stipend to help cover living expenses. Such fellowships are exceedingly valuable for trainees and very expensive for medical schools and the NIH, so admissions committees work hard to pick the right students for their programs. Despite the high training costs, when I visit other MD/PhD programs to conduct reviews, it is not uncommon to hear deans refer to their MD/PhD program as “the jewel in the crown.” One can easily argue that the existence of MD/PhD programs is evidence of the high value that our society places on physician–scientists.

ARE MD/PhD PROGRAMS LIMITED TO THOSE INTERESTED IN LABORATORY RESEARCH?

The answer varies from school to school. Not all schools offer PhD programs in all disciplines. The majority of MD/PhD students receive their PhD in biomedical laboratory disciplines such as cell biology, biochemistry, genetics, immunology, pharmacology, neuroscience, and biomedical engineering. The names of departments and graduate programs vary from school to school. At some schools, MD/PhD trainees do their graduate work outside of the laboratory disciplines, in fields such as economics, epidemiology, health care economics, sociology, medical anthropology, or the history of science. This is not an exhaustive list, and you should check before you apply to see what is actually offered at any particular school.

Although there is no fully up-to-date and reliable list of which MD/PhD programs offer training in which graduate disciplines, a place to start is at the Website of the AAMC MD/PhD section (which is a good source for other types of information as well). 2

ARE THERE OTHER WAYS TO BECOME A PHYSICIAN–SCIENTIST?

Yes. Definitely. MD/PhD programs are a great choice for people who decide early that that they want to be physician–scientists and have built the necessary track record of academic success and research experience before they apply. Not everyone does this, however, either because he or she did not learn about the option early enough, he or she did not make a decision in time, or he or she does not have an academic and research experience record that supports an application. Not finding out early enough turns out to be a common problem. In my experience, college prehealth advisors know much less about MD/PhD training than MD training—not surprisingly, since only 3% of medical school applicants in the United States every year apply for MD/PhD training. As a result, some people choose (or are obliged) to do MD/PhD training in series, rather than parallel—finishing one degree and then starting the other. The disadvantages of this approach include taking longer to finish training and the likely need to cover the cost of medical school on your own.

I am frequently asked about the strategy of starting medical school and then applying to graduate school as a medical student. Some schools will consider you for transfer into their MD/PhD programs after you have completed a year or two of medical school or graduate school at the same university. Although it is very rare that an MD/PhD program will consider accepting a medical or graduate student from a different school, it does occasionally happen when faculty move from one institution to another and want to bring their students with them. The rules and requirements vary from school to school.

Other programs worth checking out include the NIH MD/PhD program that provides support for the PhD phase at the NIH campus or in Oxford/Cambridge, with the MD training taking place at one of the participating MSTP-designated programs. Note that not all of the MSTP programs have chosen to participate, so if you have your heart set on a specific medical school, you should be sure to ask. 3

Another option is to complete medical school and residency training before doing an extended period of supervised research. A number of Nobel Prize–winning physician–scientists did just that. However, with the increase in the number of MD/PhD training programs nationwide, most people who make the decision to become physician–­scientists while still in college should think hard about doing both degrees together in an integrated MD/PhD program that combines graduate school and medical school into a joint program that currently takes 8 years on average to complete ( Akabas et al. , 2018 ).

DO I REALLY NEED A PhD TO DO RESEARCH? CAN I SAVE TIME BY SKIPPING IT?

The answer to the first of these questions is “Clearly not.” However, while medical school will put you firmly on the path to becoming an accomplished clinician, it does not provide training in how to do research. At some point you will benefit from that additional piece of your education if you intend to become a physician–scientist.

As noted above, in years past it was not uncommon to learn how to do research by doing an extended postdoctoral fellowship after (or instead of) a clinical residency. I am often asked whether it is possible to save time on the path to becoming a physician–scientist by skipping graduate school and just going to medical school. The available data suggest that the answer to this one is “No.” Physician–scientists get their first jobs in academia and their first independent NIH grants at approximately the same age regardless of whether they completed an MD/PhD program or went solely to medical school and then did a more extended postdoc ( Ginsburg et al. , 2014 ). As a result, I normally tell undergraduates that if they are ready to make the commitment before starting medical school, MD/PhD programs offer many advantages, including integrated training, mentored research training, and medical school tuition waivers. On the other hand, if you are sure you want to be a doctor, but less sure about being a scientist, then my advice is to go to medical school and figure out the rest of what you need when you know more about the opportunities that being a physician provides.

HOW DOES MD/PhD TRAINING WORK AND HOW LONG DOES IT TAKE?

The answer varies from school to school, but historically students begin with 2 years of medical school, switch to graduate school in the third year of the program, and then return to finish medical school after completing (and defending) a thesis research project. When I was an MD/PhD student in the 1970s, there was little, if any, communication between the medical and graduate phases of the program. That has changed considerably. Now most programs emphasize integration of the MD and PhD parts of the training, with graduate school courses during years 1 and 2 and clinical experiences during graduate school. Some programs allow completion of 3–12 months of clinical training before the start of full-time graduate training. Be sure to ask how things are organized at schools that you are considering. In programs leading to a PhD in laboratory science, MD/PhD trainees usually spend the summer between the first and second years of medical school working in the laboratory of the faculty member they are considering as a potential thesis advisor. Some programs also ask students to do one of these “lab rotations” in the summer before starting medical school classes as well. Depending on the number of clinical months completed before starting the thesis research, students returning to medical school will need 1–2 years to finish their training and meet the requirements for medical licensure. The stated goal is to complete an MD/PhD program in 7 or 8 years. However, numbers from across the country show that some students finish in 6 years, while others take 10 years (or more). The average currently is 8 years ( Akabas et al. , 2018 ). Note that medical education in the United States continues to evolve. One trend is away from the classic two years of preclinical education followed by 2 years of clinical education. The earlier start in clinical training made possible by shortening preclinical time enables some MD/PhD programs to offer full-time clinical experiences before the start of graduate school. However, some schools are choosing not to do this. The only way to find out what is being done is to ask, if it is not evident from the program’s Website.

HOW LONG DOES IT TAKE TO COMPLETE TRAINING AFTER GRADUATING FROM AN MD/PhD PROGRAM?

Corny as this may sound, the process is never really finished. Your education will continue throughout your career. A more pragmatic answer is that training will extend beyond medical school and graduate school as you complete your post graduate education. Here are some typical numbers: MD/PhD program, 8 years. Residency, 3–6 years. Postdoctoral fellowship, 3–6 years. For most people the term “postdoctoral fellowship” includes another year or two of clinical training, followed by a return to research for 2 or more years ( Figure 1 ). For example, I completed an MD/PhD program in 6 years, followed by a residency in internal medicine (3 years) and a fellowship in clinical hemato­logy and oncology that was combined with postdoctoral training back in a lab (3 years). After that I became an assistant professor and started my own lab. That timing was fairly typical when I did it. Now it would be considered fast. On the other hand, my job description when I finished included running a research team, looking after postdocs and graduate students, and taking care of sick people with complicated medical problems, so maybe all of that training time was necessary.

Paths to becoming a physician who is also a scientist. Integrated MD/PhD training programs that combine research and medical training are not the only path to becoming a physician–scientist. Alternatives begin with doing a research year in medical school (MD+ in the figure) or just doing the standard four-year medical school education. These save time at the start, but usually require a longer period of postgraduate clinical and research training to reach the point where a job as a physician–scientist in academia becomes feasible. As a result, physician–scientists often arrive at the “get a job” point at about the same age whether they began as medical students, MD+ students, or MD/PhD students, although usually with greater student debt if they have not been in an MD/PhD program. See the text for details.

WHAT HAPPENS TO THE GRADUATES OF MD/PhD PROGRAMS?

Short-term, nearly all do additional clinical training. Those who do not are usually headed toward careers at research institutes or outside clinical medicine entirely. Those who do apply for residencies often find that their MD/PhD training makes them particularly appealing to residency programs at top institutions. Long-term, most program graduates end up with careers in which they combine patient care and research. The research may be lab-based, translational, or clinical. Most (75–80%) end up at academic medical centers, at research institutions such as the NIH, or in the pharmaceutical/biotech industry ( Figure 2 ; Brass et al. , 2010 ; Akabas et al. , 2018 ). A much higher percentage of MD/PhD program graduates have ended up in academia than of medical school graduates in general ( Brass et al. , 2010 ). Those who build research careers and apply for NIH research grants find that having the PhD in addition to the MD improves their chances of obtaining funding ( Ginsburg et al. , 2014 ).

Where are they working? Data from 2202 MD/PhD program alumni who have completed all phases of postgraduate clinical and research training. Adapted from Brass et al. (2010) . Industry includes the biotech and pharmaceutical industries. Pvt Practice refers to full-time clinical practice outside of an academic medical center.

HOW DO I APPLY?

The process of application varies from school to school. Some schools have an MD/PhD-focused committee that will screen your application and coordinate the interview and admission process. Other schools consider MD/PhD applicants only after a decision has been made about MD admissions. Finally, some schools consider students for the MD/PhD program only after they have completed a year or more of medical school. Schools that subscribe to AMCAS will ask you to indicate your interest in an MD/PhD program and then to provide additional information as part of a secondary application.

WHEN DO I APPLY?

Most people apply after finishing their junior year in college, but a growing number of applicants finish college and work for a year or more before applying. Some people use the time after college to take courses needed for medical school admission or to gain more full-time laboratory research experience. Some people simply were not ready to make decisions about their future careers and postponed choosing beyond the finish of college. It is a mistake to assume that MD/PhD programs are interested only in applicants who have worked in a lab for a year or more after college. That is clearly not the case, and some of us who direct MD/PhD programs are concerned about the growing percentage of applicants who have waited to apply after they graduate in the mistaken impression that it will improve their resumes. My advice is that for a training path that lasts as long as this one does, it is best to get started as soon as possible.

WHAT DO ADMISSIONS COMMITTEES LOOK FOR?

The answer clearly varies from school to school, but some basic principles apply. In general, admissions committees will look for evidence of academic success, extended research experience, letters of recommendation from people who know you well, and your plans for the future.

• Evidence of academic success. This includes your GPA and MCAT scores, but is not limited to them. Admission committees use a holistic approach and will undoubtedly consider where you went to college and what types of courses you took. They will not necessarily be dismayed if you got off to a slow start, as long as you did well later. They will place the greatest emphasis on courses that are relevant to your chosen area of graduate school training. I have not encountered a program director who seriously believed that the MCAT tests your ability to be a physician–scientist. Nonetheless programs use MCAT scores in a variety of ways, including seeing how you compare with the national pool of applicants and predicting how you will do on the numerous standardized tests that all of us have to take in medical school and beyond.
• Extensive research experience. If you plan to get a PhD in one of the laboratory sciences, then prior laboratory experience counts heavily, particularly if you spent a year or more in the same laboratory. Summer laboratory experience can be helpful because they are usually opportunities to do research full time, but summers are short. Whenever possible, you should try to do research during the academic year, or at least spend multiple summers in the same lab. If you are planning a PhD outside of the laboratory sciences, seek equivalent experiences. The idea is to be sure you like the experience and to create a track record upon which your past performance can be judged and your future success predicted.
• Letters of recommendation. The most important letter(s) are from the faculty members or other senior investigators with whom you worked. The letters should ideally comment on your talents, skills, and potential for success as an independent investigator. If you are working with a senior faculty member, it is very helpful if he or she can compare you with other students with whom he or she has worked. Note that such a letter is not necessarily the most appropriate for an MD-only application. MD/PhD program admissions committees are usually most interested in your talent and ability as a physician–scientist, although they will definitely also consider whether you are likely to become a successful and caring physician. Fortunately, medical schools allow you to submit more than one letter of recommendation.
• Your plans for the future. Because training to be a physician–­investigator is so costly in terms of your time and the school’s resources, your career goals should be compatible with MD/PhD training. Becoming a full-time practitioner is a laudable goal, but does not require a PhD in addition to an MD. Your goal as a trained physician–investigator should be to spend at least 75% of your time on research. You do not need to know the specific problem you want to work on at this point (many do not, and it is likely to change), or with whom you would like to train, but your commitment to becoming an investigator should be clearly communicated in your essays and interviews, and you should have given thought to what will be required.

HOW DO I DECIDE WHERE TO APPLY?

Some applicants have decided that they want to work in a particular field or with a particular faculty member. For them, choosing where to apply is defined by where that faculty member works or where the field is best represented. Most applicants have only a general idea of what they might want to work on in the future and know that their interests are likely to evolve as they are exposed to new things. For them, choice will be defined by issues such as the reputation of the school (hopefully not based solely on U.S. News and World Report rankings!), the success of the graduates of the program (be sure to ask!), and geography. Schools vary in the difficulty of gaining admission. The directors and nonfaculty administrators of MD/PhD programs nationwide are a large pool of resources that you can tap. Most of us get e-mail from future applicants all the time. Take advantage of our willingness to talk with you. Ask questions about the things that are important to you.

FINAL THOUGHTS

I began this perspective with the confession that I am a physician–scientist and I like what I do. It is not unusual these days to encounter articles and opinion pieces that lament the difficulty of becoming and remaining a physician–scientist. I will not cite them here—you can find them on your own. Fortunately, our society is still willing to make a large investment in biomedical research through the NIH and through numerous foundations. If you want to become a physician who discovers the new stuff, there are jobs waiting to be filled. However, you will need good training and great mentorship as you learn the skills needed to be a physician and a research team leader. Good luck with your decision.

Acknowledgments

My thanks to my colleagues who direct MD/PhD programs, the NIH for supporting physician–scientist training (including my own), and the hundreds of MD/PhD candidates and alumni who have taught me so much over the past 20 years.

Abbreviations used:

DOI: 10.1091/mbc.E17-12-0721

1 www.aamc.org/data/facts/enrollmentgraduate/ .

2 www.aamc.org/students/research/mdphd/ .

3 http://mdphd.gpp.nih.gov .

• Akabas MH, Tartakovsky I, Brass LF. (2018). The National MD–PhD Program Outcomes Study. American Association of Medical Colleges Reports.
• Brass LF, Akabas MH, Burnley LD, Engman DM, Wiley CA, Andersen OS. (2010). Are MD–PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD–PhD programs . Acad Med , 692–701. [ PMC free article ] [ PubMed ] [ Google Scholar ]
• Ginsburg D, Shurin SB, Mills S. (2014). NIH Physician–Scientist Workforce (PSW) Working Group Report. [ Google Scholar ]

MSPP applications will open July 2024, and applications for program admission will open August 2024.

The Accelerated MD/PhD Partnership Training Program

Since 2006, the NIH MD/PhD Partnership Training Program has grown to a population of well over 50 aspiring young scientists across 30+ U.S. medical schools each year. The NIH  MD/PhD Partnership Training Program is designed to encourage the success and development of students pursuing a future as physician-scientists in basic and translational biomedical research. The program fosters innovative and interdisciplinary PhD partnerships in an accelerated setting with a completion time of approximately four years. Scholars enrolled in this program have the opportunity to take advantage of the unique resources available at the National Institutes of Health (NIH), including the NIH Clinical Research Center and the many options for collaboration provided by the NIH Graduate Partnerships Program (GPP).

There are opportunities available for students who have just finished their Bachelor’s degrees and are looking to apply to medical school and students who will begin medical school this fall.

• Prospective Students

Current Students

How to Apply

The first step in the application process is to determine whether you are eligible for the NIH MD/PhD Partnership Training Program. The second step is to identify which of the two tracks apply to you. More detailed information about eligibility requirements and the application process is listed on the individual track pages.

Choose Track 1 if you plan on attending medical school BEFORE you begin PhD research

Have you already started medical school? If so, you are a Track 2 applicant.

Choose Track 3 if you don't plan on attending medical school BEFORE you begin PhD research

Now in its 16th year, the NIH MD/PhD Partnership Training Program has grown to a population of well over 50 aspiring young scientists at 35 U.S. medical schools. We can proudly admit the current cohort of NIH MD/PhD Scholars are involved in some of the most cutting edge biomedical research endeavors being conducted in the world.

The MD/PhD Program leadership want to ensure that you have a place to get the information that you need. Please review the below information for resources to help you navigate through your training. 

Student Profiles Student Resources

The NIH Oxford-Cambridge Scholars Program

The NIH Oxford-Cambridge Scholars Program (OxCam) can accommodate students seeking combined MD/PhD training for a career as a physician-scientist. Students admitted to the NIH MD/PhD Partnership Training Program conduct research in the NIH intramural research program as part of a coordinated plan of dual-degree training with a U.S. medical school. Students may combine medical school training with the NIH OxCam PhD program via one of two academic tracks.

Go to NIH OxCam

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Marc Potenza, MD, PhD, Inaugural Endowed Professorship

Dr. marc potenza.

Dr. Marc Potenza was recently named the inaugural Steven M. Southwick Professor of Psychiatry.

A professorship has been established at Yale to honor and commemorate the contributions of the late Steven M. Southwick, MD, one of the world’s leading experts on psychological trauma and human resilience. The Director of the Women and Addictive Disorders Core within Women’s Health Research at Yale Marc Potenza, MD, PhD, has been named the inaugural Steven M. Southwick Professor of Psychiatry. Named professorships are among the highest honors Yale bestows on its faculty.

At the time of his death in 2022, Southwick was the Glenn H. Greenberg Professor Emeritus of Psychiatry, PTSD, and Resilience at Yale School of Medicine, and medical director emeritus of the Clinical Neuroscience Division of the National Center for PTSD of the U.S. Department of Veterans Affairs.

“I’m thrilled that Marc Potenza is the inaugural Southwick professor,” said John H. Krystal, MD, Robert L. McNeil, Jr. Professor of Translational Research and Professor of Psychiatry, of Neuroscience, and of Psychology, and chair of the Yale Department of Psychiatry. “Like Dr. Southwick, Marc has spent his entire professional career at Yale. The two were also friends and collaborators. Marc has emerged as an important leader in the addiction field and an expert in non-drug addictions, including gambling disorder.”

“I am deeply honored to be named as the Steven M. Southwick professor," Potenza said. “I am particularly grateful to have worked with Dr. Southwick and have experienced firsthand his kindness, thoughtfulness, and expertise in researching resilience in the setting of trauma. His pioneering perspective to focus on resilience is one that resonates strongly with me as resilience is key to navigating significantly disruptive life experiences. My hope is to continue research into what helps people manage stressful life events and thrive moving forward, and his work greatly facilitates future research in this area.”

Potenza, who completed his undergraduate and medical school education at Yale as well as his internship, psychiatric residency, and addiction psychiatry fellowship training, leads the Division of Addiction Research within the Department of Psychiatry. He is also director of the Center of Excellence in Gambling Research at Yale, and the Yale Program for Research on Impulsivity and Impulse Control Disorders.

At the state level, he is a senior scientist at the Connecticut Council on Problem Gambling. Nationally and internationally, he has consulted to the Substance Abuse and Mental Health Services Administration, National Registry of Effective Programs, National Institutes of Health, American Psychiatric Association, and World Health Organization on matters of addiction. He is on the boards of multiple national organizations including Children and Screens, the Addiction Policy Forum, and the National Center on Problem Gambling and is the president-elect of the International Society of Addiction Medicine.

Featured in this article

• Marc Potenza, PhD, MD Steven M. Southwick Professor of Psychiatry and Professor in the Child Study Center and of Neuroscience; Director, Center of Excellence in Gambling Research; Director, Yale Program for Research on Impulsivity and Impulse Control Disorders; Director, Women and Addictive Disorders, Women's Health Research at Yale

EDI Spotlight: Tammara Watts, MD, PhD

Frequently finding herself the only Black woman surgeon in certain spaces, Tammara Watts MD, PhD, has recognized the importance of making workplaces more inclusive for some time. However, it wasn’t until two years ago that she began working in equity, diversity, and inclusion in an official capacity.

Both in her roles as a head and neck cancer researcher and associate director of the Office of Equity, Diversity, and Inclusion for Duke Cancer Institute, Watts has made it her mission to address cancer disparities and diversify the oncology workforce. In this month’s EDI Spotlight, she shares how a nearly $2 million grant she recently received from the National Institutes of Health will help her do just that. She also gives us a glimpse into some of the work her DCI colleagues are doing to advance health equity and reveals her love of riding horses. 

What is your official EDI-related title within the Duke Cancer Institute? What does this role entail, and how does it complement your other responsibilities as associate professor of head and neck surgery and communication sciences? 

In the DCI, I am the associate director of the Office of Equity, Diversity, and Inclusion. As an NCI-designated comprehensive cancer center, I am charged with strategic planning and implementation of the DCI’s Plan to Enhance Diversity (PED). The PED is a new component for all NCI-designated cancer centers with the goal to design programs to support recruitment, retention, and career development of women and individuals underrepresented in the scientific workforce.

Tell us about some of the work DCI is doing to eliminate cancer disparities and advance health equity. 

There is a lot of work being done in this space. We can't be in an era of personalized cancer care if we don't take care of all of the patients and all of our communities. Advancing health equity is one of the pillars in the 2022-2027 DCI Strategic Plan. There are several DCI investigators whose work, both in the lab and at the bedside, is focused on eliminating cancer disparities.

Our Community Outreach, Equity, and Engagement Office did a community scientific round table where community members met with DCI scientists who are working in cancer disparities. My takeaway from that was how the community wants to know how their samples are being used and how their tissues are helping further science.

In addition to research in gastric, breast, endometrial, and prostate cancer focused on understanding the biology of cancer disparities, and evaluating outcomes from clinical trials, DCI created a program called Just Ask , which has been adopted nationally to raise awareness of how implicit basis affects patients of color in even being asked if they would like to participate in a clinical trial.

You recently were awarded a five-year, $1.9 million grant aimed at improving head and neck cancer outcomes and diversity in the oncology workforce. Can you tell us a little about the grant and who will benefit from this research?

I was fortunate to be one of the inaugural recipients of the NIH R01 called ReWARD . It was a new mechanism put in place by the NIH because a lot of investigators spend time working in the space of diversity, equity, and inclusion, but they don't get any funding or support.

The grant [titled Disparate Outcomes, Disparate Workforce: An Integrated Approach to Improving Head and Neck Cancer Outcomes and Diversity in the Oncology Workforce] has four aims. The first two aims are scientific. Black patients do very poorly with head and neck cancer, even if you control for socioeconomic factors. We want to use a genomics approach and see if we can understand if there are gene-related differences between Black and White patients with head and neck cancer that can inform additional studies to test whether these genetic differences are indeed impactful when it comes to outcomes, and then begin to design treatments around that.

The third aim supports a high school student coming from City of Medicine Academy in Durham to spend time in my lab or any of the labs of the co-investigators to learn about what it is like to conduct oncology-based research. They will come in the summer before they start their junior year and earn high school credit during the spring semester, with the goal of having them participate as a member of the research team to showcase in their college applications.

Fourth, we are partnering with Howard University to send one of their surgery residents for one to two years to do oncology-based research at Duke. The grant provides support for their training. They're not required to do head and neck cancer research. If they want to learn about breast, pancreatic, or gastric cancer, it doesn't matter. The grant is there to support them and help them with their interests. And if they stay for two years, we'll even help support their tuition if they want to get an advanced degree, like a master's degree.

We will also provide mentorship and incubator space for a junior faculty member who wants to start their own translational lab.

What inspired you to begin working to improve equity, diversity, and inclusion within Duke?

I wasn't really working in the cancer disparity space initially. As a Black woman, an MD-PhD surgeon, you're usually a party-of-one in these spaces. And so, you are always thinking about how to include people.

But I didn't get truly inspired with that conscious thought until I started working on the cancer disparities research two years ago. My colleague Dr. Nosa Osazuwa-Peters encouraged me to use my science background to explore head and neck cancer disparities. I became curious and with support with pilot funding from the DCI P20 Disparities SPORE and Dr. Steve Patierno , who's very passionate in this space, thus ignited my own passion. My role in the DCI has become one of my favorite jobs.

I was fortunate that I had the opportunity to get exposure to research early on. I don't know that a lot of our young folks see what research is like. So, one of the things I wanted to make sure on this NIH grant was to have a lot of mentors doing different kinds of research.

About 85% of the students at City of Medicine Academy are students of color. They're interested in the health professions, but I don't know if they know about the non-obvious ones, like molecular epidemiology, bioinformatics, and medical physics as examples of science disciplines that work within the context of cancer. Having that exposure early on as a means to help increase our workforce diversity is vital. I wanted these students to have a much earlier exposure, while in high school which they could carry with them as they enter college. I wanted there to be a broad group of mentors to draw on. And the same thing for the Howard University surgical resident who comes here; they'll get mentorship from surgeons here and develop their research skills with the hope that they choose Duke for their surgical oncology fellowship.

What passions or hobbies do you have outside of work?

I love to ride horses. I have been riding for over 30 years. I have fallen off, broken bones and always get back on the horse. The pandemic brought me the joy of Pilates and I'm an aspiring new golfer.

What It's Like to Do an MD-PhD Program

New section.

Two medical students answer questions about what it's like to do an MD-PhD program.

Elias (Eli) Wisdom

Undergraduate:   Pacific University, Oregon Major:   BS, Biology Medical school:  Oregon Health & Science University (OHSU) Anticipated Graduation Year:  2028 Bio: Eli Wisdom is an MD-PhD student at Oregon Health & Science University (OHSU) studying the molecular mechanisms of Parkinson’s Disease. He grew up in the small rural town of La Grande, Oregon,  where he gained a deep appreciation for community and service and a fascination with the natural world. At Pacific University, he completed his degree in Biology while also a playing varsity baseball. After graduating he was as an Associate in Neuroscience at Yale School of Medicine for two years before starting an MD-PhD program. Outside of school, he enjoys competing in triathlons, camping, and spending time with family.

Sreya Sanyal

Undergraduate:  New Jersey Institute of Technology        Major:  Biology & History Double Major Medical school:   Rutgers Robert Wood Johnson Medical School Anticipated Graduation Year:  2031 Bio: Sreya Sanyal is a MD-PhD student at Robert Wood Johnson Medical School and Princeton University. She is Bengali and she aspires to become a laboratory principal investigator in the field of oncology. Outside of academia, she enjoys singing, cooking, going to museums, and lifting at the gym.  

Why did you decide to pursue an MD-PhD program?

Eli:  As an undergraduate student, I found my first biomedical research experience to be quite thrilling and seriously considered pursuing a career in research. Medical school had surfaced as an opportunity, too, as I was deeply passionate about serving others and caring for the sick, but I felt that basic science research was the backbone of advancing clinical care. I first learned that combined MD-PhD programs existed in my senior year when I was taking part in a summer research program at another academic institute. I learned that in a dual-degree program, I could become rigorously trained as a research scientist and as a physician – and could do both in my future career. To learn more, I reached out to a few physician-scientists to who shared how much they loved their careers. In the clinic, their patients and associated medical problems provided new ideas for exploration in the laboratory. And in the laboratory, the insights they gained could inform the way they treated their patients. Sreya:  I’ve wanted to become an oncologist ever since I was 11 and my mother died from gastric cancer. When I shadowed hematologist oncologists in academic settings, I became more interested in their work in clinical trials and research. Entering college, I explored translational research through my undergraduate biomedical engineering lab experiences. As I met more people in the field of drug development and oncology, I realized that I wanted to be at the cutting edge of this work, but I still had the desire to see patients. Through a lot of soul searching and luck, I was able to embark on a career in medical research by pursing an MD-PhD. Using my training as a physician-scientist, I plan to establish my own lab or work in other ways to improve translational research in the oncological space.

What kinds of career options does the MD-PhD program give you?

Eli:   From my experience, rigorous training in medicine and scientific research prepares you best for a career in academic medicine. This often means working at a large teaching hospital, where you have an opportunity to conduct independent scientific research, care for patients, and teach students. While it can differ depending on the medical specialty or the individual, a typical physician-scientist may spend 80% of their time conducting research and 20% caring for patients.  However, there are many other career paths available to MD-PhD graduates. Students may also pursue careers working for private research organizations, pharmaceutical and biotechnology companies, or government agencies.  Sreya:  In my experience as an MD-PhD student interested in oncology, I have a wide array of career options to explore. As a clinician-scientist, I can lead research teams and conduct studies in cancer biology, treatment approaches, and translational medicine. In these roles, I can also mentor students interested in my field, allowing me to advance scientific knowledge while shaping the next generation of researchers. Alternatively, I could directly impact patients' lives by increasing my clinical time spent as an oncologist, developing personalized treatment plans, and contributing to clinical trials. The pharmaceutical and biotechnology industries also present exciting opportunities for me where I would be able to work on drug development, clinical research, or medical affairs, playing an essential role in bringing innovative therapies to market. With my combined medical and research expertise, I am well-equipped to make a meaningful difference in oncology through various rewarding career paths.

What type of research experience did you have before entering the program?

Eli: I attended a liberal arts college where students engaged in scientific research through 2–4-month long classes, which were combined lecture and laboratory experiences. Building on excitement from these courses, I pursued a summer research internship at a large biomedical research institute the summer prior to my senior year. I loved this initial exposure to working in a high-powered scientific research center. From working in state-of-the-art reach laboratories, to solving scientific problems in creative ways, and watching physicians bounce between research and patient care – I was hooked.  Sreya:  Before starting my current program, I had two significant research experiences. First, I worked in a lab that focused on creating materials for drug delivery in the field of biomedical engineering. We used special gels to deliver important substances to specific parts of the body, which had significant effects on the surrounding tissues, such as promoting blood vessel growth and blocking certain enzymes. I spent about 10 hours a week for three years in this lab and contributed to three published papers.

Secondly, I worked at a research institute where I studied mice that were genetically modified to show signs of anthrax toxin exposure. These modified toxins could be controlled to specifically target tumor cells in the body. I dedicated 40 hours a week to this research, and as a result, we have two research papers in progress for publication

How did you prepare to apply to MD-PhD programs?

Eli: Since I had played varsity baseball throughout college (which was impactful training in its own right,) I had limited time for research as an undergraduate. So, I decided to pursue an extended research position before applying to MD-PhD programs. After sending several emails to laboratories across the US and applying to many formal postbacc research programs, I took a two-year job as a postgraduate researcher at an academic research institute. During my time working on a project in a laboratory, I also volunteered at the connected hospital. This allowed me to experience what it was like to conduct independent research during the first part of my day, and care for patients in the afternoon. This experience only confirmed my deeply held passions for both medicine and science, but also exposed me to the challenges that both careers entailed. I felt much more confident in my decision to pursue a dual-degree knowing these insights.

What is your favorite part about being an MD-PhD student?

Eli: Thus far, my favorite part of my training has been directly experiencing the intersection of clinical care and research. During the first two years of the MD-PhD, I was mainly focused on medical school courses and preparing for the first board exam. But now, as I am beginning my Ph.D., I am realizing how medical school has broadened my perspective. When I read research papers or craft a plan to tackle a hypothesis, I feel empowered with the knowledge I learned in my didactic medical school courses. For example, during one of my Ph.D. research rotations, a scientist was having difficulty delivering a therapeutic to the brains of the mice they were studying. Immediately I recalled from my medical school courses how mannitol could be co-infused to transiently open the blood-brain barrier for drug delivery. It could easily be translated to this scenario. Similarly, my experiences with clinic patients have benefited from my MD-PhD training. Often, it can be as simple as the ability to explain to a patient or their family, the exact mechanism of a drug and the reason it could be effective for their ailment. Or, informing them about current basic science efforts in the field or current clinical trials they might be eligible for. As I advance further into my training, I am eager to see how clinical care and laboratory research can become even more intertwined. Sreya:  I am very excited to learn new techniques and approaches to my field of interest. I am also glad that for MD-PhD students in my program, there is a huge emphasis on lifestyle and work/life balance. Many students in my program have become engaged, or married, and are starting families, while many medical students may feel pressure to push these milestones off. Being an MD-PhD student is a huge commitment, so I am especially grateful for all of the personal and professional support my program has to offer.

What do you wish you’d known before you started the program?

Eli: I wish I had known how important it would be to keep an open mind about the research topics that interested me most. I began the MD-PhD program with a rigid focus on a certain topic, thinking that it was the only topic that gave me real excitement. It was also the topic I was most versed in and comfortable in. But during my medical school courses, I was suddenly overwhelmed with several fascinating questions and problems, that all seemed equally thrilling. It took a fair bit of mental wrestling with myself to broaden my own research interests and muster up the courage to explore a field I was fascinated with even if I didn’t have the most experience in it quite yet. Luckily, MD-PhD programs are usually quite supportive of students exploring new topics of interest and are eager to see you follow your motivations.

Sreya:  One of the most important aspects to consider for MD-PhD students is the idea that this path is a marathon, not a sprint. There is a lot of temptation to overload on clubs, leadership, research, etc., to keep pace with MD colleagues, but in the long run, an MD-PhD is about the quality and depth of training. It’s important to build healthy habits, strong social relationships, and enjoy activities in a sustainable manner since MD-PhD students have to do another graduate degree on top of medical training.

What advice would you give a student considering an MD-PhD program?

Eli:  My advice is to accrue as many experiences as you can in medicine and research before applying. Through these, you can understand if pursuing both an MD and a PhD is the best fit for you, or, if you’d be completely satisfied pursuing a career with only training in one discipline. If you can, shadow physicians at both large academic hospitals and private practices. This can teach you if you’d enjoy treating patients daily and give you insight into how your experience will vary based on the setting. Seek out research experiences as early as possible. This may be difficult to procure, but having a longitudinal research experience that encompasses the successes and failures of science will inform you if this should be your future career. If you can, ask for opportunities to experience what it’s like to write a grant or an academic research article. These are not easy to write, yet they encompass a significant amount of time for professional physician-scientists, so, it is important to learn if you’d enjoy (or at least tolerate) the academic writing load. Lastly, don’t be intimidated by the amount time it takes to complete an MD-PhD. Yes, it is longer than most post-graduate training and takes up a significant portion of your early life. But it is a unique and worthy career path that is much needed in service to society. Sreya:  My advice to anyone considering an MD-PhD would be to get both a variety and depth of research experiences. As a student, it’s very easy to continue down a path you already started, but you must try to explore before you commit to any one approach. MD-PhD programs appreciate students who know what they would like to research and the only way to discover this is to pursue broad research experiences. That said, once you find what drives and excites you, it’s important to stick with it and maintain good relationships with your PIs and mentors. It’s a small world among physician-scientists, so depth of work and networking will help you achieve and further your goals. Above all, remember that an MD-PhD is not necessary to do research as a physician. The goal of an MD-PhD is to provide the specific training needed to conduct research above and beyond what a physician alone can do. In this case, you must really be sure that research is fulfilling and allows you to achieve your career goals when applying to programs, as they will ask you about your aspirations.

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Translating Pre-Medical Experiences into Clinical Skills

Michael Foster | May 3, 2023

Your time before medical school is golden. It is a unique time to explore where your passions lie (both within and beyond medicine) and lay a strong foundation of the inter- and intrapersonal skills needed for you to be the best physician you can be. The best advice is simple: challenge yourself, be honest, and have fun! […]

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M.D./Ph.D. Training Program

Ashley anderson.

Current Program Year: Grad 4 Current Student, Program in Biomedical Sciences, Anesthesiology and Perioperative Medicine, School of Medicine M.D./Ph.D. Program Students, School of Medicine Graduate Program in Biomedical Sciences Students, School of Medicine

Melissa H. Wong Lab

Research Interests: Cancer biology, pediatric neuro-oncology, image analysis

Education and training

B.S., 2015, University of Portland

Memberships and associations:

• American Medical Womens Association

Additional information

ResearchGate

Honors and awards

ARCS Scholar Award, 2020

Publications

Selected publications.

Ouyang X,  Barling AN , Lesch A, Tyner J, Choonoo G, Zheng C, Jeng S, West T, Clayburgh D, Courtneidge S, McWeeney S, Kulesz-Martin M. Induction of anaplastic lymphoma kinase (ALK) as a novel mechanism of EGFR inhibitor resistance in head and neck squamous cell carcinoma patient-derived models. Cancer Biology & Therapy, June 2018.

Kulesz-Martin M, Ouyang X,  Barling AN , Gallegos JR, Liu Y, Medler T. Multistage Carcinogenesis: Cell and Animal Models. Comprehensive Toxicology, January 2017.

Thompson JR, Valleau JC,  Barling AN , Franco JG, DeCapo M, Bagley J, Sullivan EL. Exposure to a high fat diet during early development programs offspring behavior by impairing the central serotonergic system in juvenile nonhuman primates. Frontiers in Endocrinology, July 2017.

Liu Y, Wang Z, De La Torre R,  Barling AN , Tsujikawa T, Hornick N, Hanifin J, Simpson E, Wang Y, Swanzey E, Wortham A, Ding H, Coussens L, Kulesz-Martin M. Trim32 deficiency enhances Th2 immunity and predisposes to features of atopic dermatitis. Journal of Investigative Dermatology, Oct 2016.